The Mike & Sofia Segal Foundation makes a small number of very large, unrestricted operations grants to institutional recipients, with a strong tilt toward medical research (especially cancer and rare-disease organizations) and selective investments in education and public policy research. Grants are national in scope and support established nonprofits and academic centers rather than grassroots groups, indicating a preference for capacity-building for proven organizations.
A $3.5 million unrestricted operations grant to the Leukemia & Lymphoma Society shows the scale and style of the Mike & Sofia Segal Foundation’s giving: concentrated, institutional, and built around a few large checks rather than many small awards. The foundation’s 2025 grants also show a second major medical commitment, with $1.406 million to the Ehlers-Danlos Society and $600,000 to Moffitt Cancer and Research, alongside support for academic and civic institutions. Across the recent grant list, medical research and patient advocacy sit next to Jewish heritage, intellectual freedom, elder care, climate-related work, and education. The recipients are established nonprofits and universities, and the grants are almost entirely operational in purpose, which points to general support for organizations already carrying substantial programs. The foundation’s portfolio includes university-based policy research, youth educational media, and community institutions, but the largest checks are clearly aimed at serious medical conditions and the organizations working on them. That mix makes the foundation legible as a large, selective funder that backs proven organizations in a narrow set of priority areas.
Medical research is a central theme. In 2025, the foundation gave $600,000 to Moffitt Cancer and Research for operations, and $100,000 to Digestive Disease Research Foundation for operations, showing support for both cancer-related and other underfunded health research. Rare-disease work is another clear line: the Ehlers-Danlos Society received $1.406 million for operations. The foundation also funds education and intellectual life. Hetreodox Academy received $1 million for operations, and Constructive Dialogue Institute received $250,000 for operations, tying the grantmaking to civil discourse and academic freedom themes. Educational programming appears as well, with $541,780 to Jigsaw Educational Productions for operations. Cultural and communal support is present through grants such as $300,000 to American Friends of Beit Hatfutsot for operations and $200,000 to Museum of the Jewish Soldier for operations.
The recent grants are highly concentrated at the top: $1.406 million at the 25th percentile, a $300,000 median, and $600,000 at the 75th percentile. Every recent grant listed is for operations, not project-only support. The foundation is a private foundation and a regular funder, and the grant list shows repeat recipients within the same year, including Leukemia & Lymphoma Society, The Washington Institute, and Combat Hate Foundation. That pattern suggests sustained relationships rather than one-off awards. The active programs also indicate that it accepts unsolicited inquiries in several areas, including medical research, Jewish heritage, intellectual freedom, elder care, and climate change.
$12.2M
$9.3M
$13M
$12.9M
Top 3 recipient countries by grant volume for Mike & Sofia Segal Foundation.
| Rank | Country | Grants | Total | Share |
|---|---|---|---|---|
| 1 | United StatesDomestic | 76 | $22.5M | 97.4% |
| 2 | Israel |
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Highly concentrated giving: very few, large grants focused on operations rather than project-level funding; tends to fund established national organizations and university centers rather than many small or local grantees.
Notable grantees: Leukemia & Lymphoma Society, Ehlers‑Danlos Society, Hetreodox Academy, Columbia University — Center on Global Energy Policy, Jigsaw Educational Productions
The foundation’s giving is geographically tight: 100% of grants in the recent dataset go to recipients in New York State, even though the recipients themselves are spread beyond one city. New York, NY appears repeatedly, including for Leukemia & Lymphoma Society, Ehlers-Danlos Society, and Weill Cornell Medical College. Other recipient locations include Washington, DC; Tampa, FL; Cambridge, MA; and Charleston, SC. Outside the U.S., the country distribution shows one grant in Israel and one in India, indicating occasional international support alongside the New York-centered pattern.
Its recent grants favor established nonprofits and academic centers. The list includes medical groups such as Leukemia & Lymphoma Society, the Ehlers-Danlos Society, and Moffitt Cancer and Research, plus universities and policy-oriented institutions such as Columbia University - Center on Global Energy Policy and Massachusetts Institute of Technology.
In the recent grant list, the 25th percentile is $1.406 million, the median is $300,000, and the 75th percentile is $600,000. The distribution shows a small number of very large grants rather than many modest awards.
Yes. Active programs for Medical Research (including Rare Diseases), Climate Change, Jewish Heritage, Intellectual Freedom / Civil Discourse, Elder Care, and General Grantmaking / Grant Inquiries all indicate that unsolicited inquiries are accepted in those areas.
Medical research and patient advocacy are prominent, especially cancer and rare-disease work. The list also includes Jewish heritage and community institutions, intellectual freedom and civil discourse, education-oriented grants, and a grant to Columbia University - Center on Global Energy Policy.
Yes. The recipient-country distribution shows 31 U.S. grants, plus one in India and one in Israel. By state, 100% of the recent grants go to recipients in New York, and New York, NY appears often among the recipient cities.
2025
Source: IRS Form 990-PF, fiscal year 2025.
| 1 |
| $200K |
1.3% |
| 3 | India | 1 | $5K | 1.3% |
Recipient country reflects the grantee's headquarters per IRS 990-PF and Schedule F filings, not the program's implementation country.
Current and upcoming funding from Mike & Sofia Segal Foundation that your nonprofit may be able to apply for.
Who can apply: Organizations developing partnerships, ideas, and communities with strong impact on climate change may be considered; the foundation notes that climate change requires long-term solutions and multi-year funding.
Who can apply: No public eligibility criteria stated in the scraped content; the foundation indicates it funds Jewish community and Israel-related causes and accepts grant inquiries.
Who can apply: Projects serving underserved elder care needs may be considered; no further criteria were identified in the scraped content.
Who can apply: Organizations or initiatives advancing open inquiry, constructive dialogue, intellectual pluralism, or free expression may be considered; the foundation indicated it will continue to invest in initiatives in this arena.
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Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| LEUKEMIA & LYMPHOMA SOCIETY | NEW YORK, NY | $3,500,000 | 2025 | OPERATIONS |
| EHLERS-DANLOS SOCIETY | NEW YORK, NY | $1,406,108 | 2025 | OPERATIONS |
| HETREODOX ACADEMY | NEW YORK, NY | $1,000,000 | 2025 | OPERATIONS |
| COLUMBIA UNIVERSITY - CENTER ON GLOBAL ENERGY POLICY | NEW YORK, NY | $600,000 | 2025 | OPERATIONS |
| MOFFITT CANCER AND RESEARCH | TAMPA, FL | $600,000 | 2025 | OPERATIONS |
| JIGSAW EDUCATIONAL PRODUCTIONS | NEW HARBOR, ME | $541,780 | 2025 | OPERATIONS |
| AMERICAN FRIENDS OF ALUMOT OR | CHARLESTON, SC | $529,500 | 2025 | OPERATIONS |
| WEILL CORNELL MEDICAL COLLEGE | NEW YORK, NY | $500,000 | 2025 | OPERATIONS |
| LEUKEMIA & LYMPHOMA SOCIETY | NEW YORK, NY | $400,000 | 2025 | OPERATIONS |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | CAMBRIDGE, MA | $400,000 | 2025 | OPERATIONS |
| THE WASHINGTON INSTITUTE | WASHINGTON, DC | $400,000 | 2025 | OPERATIONS |
| THE NEW JEWISH HOME | NEW YORK, NY | $300,000 | 2025 | OPERATIONS |
| AMERICAN FRIENDS OF BEIT HATFUTSOT | NEW YORK, NY | $300,000 | 2025 | OPERATIONS |
| CONSTRUCTIVE DIALOGUE INSTITUTE | NEW YORK, NY | $250,000 | 2025 | OPERATIONS |
| PEF ISRAEL ENDOWMENT FUNDS (NIV NIREL) | NEW YORK, NY | $200,000 | 2025 | OPERATIONS |
| MUSEUM OF THE JEWISH SOLDIER | KIRON | $200,000 | 2025 | OPERATIONS |
| HAROLD GRINSPOON FOUNDATION | AGAWAM, MA | $200,000 | 2025 | OPERATIONS |
| THE WASHINGTON INSTITUTE | WASHINGTON, DC | $150,000 | 2025 | OPERATIONS |
| DIGESTIVE DISEASE RESEARCH FOUNDATION | NEW YORK, NY | $100,000 | 2025 | OPERATIONS |
| AREVIM PHILANTHROPIC GROUP | NEW YORK, NY | $100,000 | 2025 | OPERATIONS |
| FRIENDS OF IR DAVID | NEW YORK, NY | $100,000 | 2025 | OPERATIONS |
| AMERICAN ISRAEL EDUCATION | WASHINGTON, DC | $75,000 | 2025 | OPERATIONS |
| INSTITUTE FOR THE STUDY OF GLOBAL ANTI-SEMITISM AND POLICY | NEW YORK, NY | $50,000 | 2025 | OPERATIONS |
| COMBAT HATE FOUNDATION | MOUNDRIDGE, KS | $50,000 | 2025 | OPERATIONS |
| AREVIM I | HILLBURN, NY | $50,000 | 2025 | OPERATIONS |
| COMBAT HATE FOUNDATION | MOUNDRIDGE, KS | $50,000 | 2025 | OPERATIONS |
| BAPTIST HEALTH FOUNDATION | LITTLE ROCK, AR | $36,000 | 2025 | OPERATIONS |
| JCC OF MID-WESTCHESTER | SCARSDALE, NY | $36,000 | 2025 | OPERATIONS |
| FUND FOR THE AGED | NEW YORK, NY | $30,000 | 2025 | OPERATIONS |
| ALEPH INSTITUTE | SURFSIDE, FL | $25,000 | 2025 | OPERATIONS |
| IRAQ AND AFGHANISTAN VETERANS OF AMERICA | WASHINGTON, DC | $15,000 | 2025 | OPERATIONS |
| UHEALTH AT FISHER ISLAND | MIAMI, FL | $10,000 | 2025 | OPERATIONS |
| AFPRO | NEW DELHI | $5,000 | 2025 | OPERATIONS |
| LEUKEMIA & LYMPHOMA SOCIETY | NEW YORK, NY | $3,000,000 | 2024 | OPERATIONS |
| EHLERS-DANLOS SOCIETY | NEW YORK, NY | $1,406,108 | 2024 | OPERATIONS |
| COLUMBIA UNIVERSITY | NEW YORK, NY | $600,000 | 2024 | OPERATIONS |
| WEILL CORNELL MEDICAL COLLEGE | NEW YORK, NY | $500,000 | 2024 | OPERATIONS |
| DANA FARBER INSTITUTE | BOSTON, MA | $500,000 | 2024 | OPERATIONS |
| THE WASHINGTON INSTITUTE | WASHINGTON, DC | $400,000 | 2024 | OPERATIONS |
| JEWISH COMMUNAL FUND | NEW YORK, NY | $350,000 | 2024 | OPERATIONS |
| THE NEW JEWISH HOME | NEW YORK, NY | $300,000 | 2024 | OPERATIONS |
| WEITZMAN NATIONAL MUSEUM | PHILADELPHIA, PA | $200,000 | 2024 | OPERATIONS |
| THE WASHINGTON INSTITUTE | WASHINGTON, DC | $200,000 | 2024 | OPERATIONS |
| HAROLD GRINSPOON FOUNDATION | AGAWAM, MA | $200,000 | 2024 | OPERATIONS |
| AMERICAN CANCER SOCIETY | NEW YORK, NY | $198,000 | 2024 | OPERATIONS |
| MOFFITT CANCER AND RESEARCH | TAMPA, FL | $153,012 | 2024 | OPERATIONS |
| MOFFITT CANCER AND RESEARCH | TAMPA, FL | $148,643 | 2024 | OPERATIONS |
| THE NEW JEWISH HOME | NEW YORK, NY | $100,000 | 2024 | OPERATIONS |
| COMBAT HATE FOUNDATION | MOUNDRIDGE, KS | $100,000 | 2024 | OPERATIONS |
| CENTER FOR PEACE | BROOKLYN, NY | $36,000 | 2024 | OPERATIONS |
HETREODOX ACADEMY
$1,000,000OPERATIONS
MOFFITT CANCER AND RESEARCH
$600,000OPERATIONS
JIGSAW EDUCATIONAL PRODUCTIONS
OPERATIONS
AMERICAN FRIENDS OF ALUMOT OR
$529,500OPERATIONS
LEUKEMIA & LYMPHOMA SOCIETY
$400,000OPERATIONS
THE WASHINGTON INSTITUTE
$400,000OPERATIONS
THE NEW JEWISH HOME
$300,000OPERATIONS
MUSEUM OF THE JEWISH SOLDIER
$200,000OPERATIONS
THE WASHINGTON INSTITUTE
$150,000OPERATIONS
DIGESTIVE DISEASE RESEARCH FOUNDATION
$100,000OPERATIONS
AMERICAN ISRAEL EDUCATION
$75,000OPERATIONS
INSTITUTE FOR THE STUDY OF GLOBAL ANTI-SEMITISM AND POLICY
$50,000OPERATIONS
AREVIM I
$50,000OPERATIONS
JCC OF MID-WESTCHESTER
$36,000OPERATIONS
FUND FOR THE AGED
$30,000OPERATIONS
UHEALTH AT FISHER ISLAND
$10,000OPERATIONS
AFPRO
$5,000OPERATIONS
COLUMBIA UNIVERSITY
$600,000OPERATIONS
THE WASHINGTON INSTITUTE
$400,000OPERATIONS
THE NEW JEWISH HOME
$300,000OPERATIONS
WEITZMAN NATIONAL MUSEUM
$200,000OPERATIONS
THE WASHINGTON INSTITUTE
$200,000OPERATIONS
MOFFITT CANCER AND RESEARCH
$153,012OPERATIONS
MOFFITT CANCER AND RESEARCH
$148,643OPERATIONS
THE NEW JEWISH HOME
$100,000OPERATIONS
CENTER FOR PEACE
$36,000OPERATIONS
