
The G. Harold & Leila Y. Mathers Foundation is dedicated to advancing knowledge in the life sciences by funding bold, basic scientific research with the potential to transform human health. The Foundation supports early-stage, high-risk/high-reward foundational discoveries that can lead to translational impact and future medical breakthroughs.
The G Harold & Leila Y Mathers Charitable Foundation backs bold, basic scientific research with translational potential in the life sciences, especially projects that aim to open paths toward human health advances. Its recent awards are concentrated in research universities, medical centers, and scientific institutions, with a pattern of sizable project-level grants rather than small awards. In the recent-grants list, Columbia University received $532,609 for a research project, and Massachusetts Institute of Technology received $321,540 for another research project, reflecting the foundation’s focus on foundational inquiry at established institutions. Rockefeller University also appears multiple times in the recent awards, including grants of $308,334, $308,000, $300,000, $277,200, and $271,205, showing repeated support for research teams working in the foundation’s core scientific areas. The foundation’s active programs describe three-year grants for early-stage, high-risk, high-reward basic research, including work in immunology, microbiome, structural biology, cancer biology, genetics, genomics, microbiology and infectious diseases, stem cell biology, and neuroscience. Its grantmaking is aimed at scientific institutions pursuing project-based research support.
In immunology, microbiome, structural biology, cellular physiology, cancer biology, genetics, genomics, microbiology and infectious diseases, stem cell biology, and neuroscience, the foundation funds project-level research rather than broad institutional support. Columbia University received $532,609 for a research project, fitting the foundation’s emphasis on basic science with translational potential. Massachusetts Institute of Technology received $321,540 for a research project, while Yale University received multiple research awards, including $303,876, $300,243, $298,372, $284,525, and $268,534, showing sustained support for laboratory-based inquiry across years. The General Hospital Corp Dba Mass General Hospital received $275,000 for a research project, pointing to the foundation’s interest in work tied to medical research settings. Across these grants, the common thread is early-stage scientific discovery designed to advance understanding in the foundation’s named life-science disciplines.
$14.4M
$107.9M
$29.2M
$18.5M
Most grants fall between $150K and $252K, with a median of $227K.
25th Percentile
$150K
Median
$227K
75th Percentile
$252K
About 24% of grants go to recipients in MA.
Sign up for a free Kindora account to access AI-generated insights into this funder's giving patterns, decision-makers, and fit signals.
Get Started FreeFree Kindora accounts unlock side-by-side comparisons with foundations that share this funder's focus areas and giving profile.
Get Started FreeSign up free to see how well your nonprofit fits this funder, get an AI-generated pitch, and unlock similar foundations.
Typical awards are in the low six figures: the p25 grant size is $149,826, the median is $227,046, and the p75 is $252,234. The recent grants list also shows larger project awards above that range, including $532,609 and several grants near or above $300,000. The foundation is a regular funder, not a DAF, and it does not fund individuals. Its grants appear as project-based awards to nonprofit universities, hospitals, and research institutes. Recent years show repeat support to the same institutions, including multiple awards to Rockefeller University, Yale University, Massachusetts Institute of Technology, California Institute of Technology, and New York University.
The foundation gives nationally, and all listed recipient-country data are in the United States. By grant count, Massachusetts is the top state, while 26% of grants go to recipients in New York, the foundation’s HQ state. Recent awards cluster in New York City, Boston, New Haven, Pasadena, and Stanford. Examples include Columbia University and New York University in New York, Massachusetts Institute of Technology and Mass General Hospital in Boston, Yale University in New Haven, California Institute of Technology in Pasadena, and Leland Stanford Junior University in Stanford.
It funds nonprofit medical research universities and scientific institutions, with grants made to research teams and research institutions rather than individuals. Recent awards went to Columbia University, Yale University, Massachusetts Institute of Technology, and other research institutions for specific research projects.
The foundation’s typical award is in the low six figures. The grant-size distribution is p25 at $149,826, median at $227,046, and p75 at $252,234, with some recent project grants rising above $300,000.
Its active programs name immunology, microbiome, structural biology, cellular physiology, cancer biology, genetics, genomics, microbiology and infectious diseases, stem cell biology, and neuroscience. The program descriptions emphasize basic science with translational potential.
No. Both active grant programs are described as limited-competition or competitive programs, and each says it does not accept unsolicited applications.
Yes. Several institutions appear multiple times in the recent-grants list, including Rockefeller University, Yale University, Massachusetts Institute of Technology, California Institute of Technology, and New York University. That pattern suggests repeated project support across years.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| ROCKEFELLER UNIVERSITY | NEW YORK, NY | $277,200 | 2025 | RESEARCH PROJECT |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | BOSTON, MA | $270,000 | 2025 | RESEARCH PROJECT |
| YALE UNIVERSITY | NEW HAVEN, CT | $268,534 | 2025 | RESEARCH PROJECT |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | PASADENA, CA | $264,398 | 2025 | RESEARCH PROJECT |
| LELAND STANFORD JUNIOR UNIVERSITY | STANFORD, CA | $259,200 | 2025 | RESEARCH PROJECT |
| CHILDREN'S HOSPITAL CORP (BOSTON CHILDREN'S HOSPITAL) | BOSTON, MA | $256,184 | 2025 | RESEARCH PROJECT |
| CHILDREN'S HOSPITAL CORP (BOSTON CHILDREN'S HOSPITAL) | BOSTON, MA | $253,000 | 2025 | RESEARCH PROJECT |
| VANDERBILT UNIVERSITY MEDICAL CENTER | NASHVILLE, TN | $252,199 | 2025 | RESEARCH PROJECT |
| ROCKEFELLER UNIVERSITY | NEW YORK, NY | $250,000 | 2025 | RESEARCH PROJECT |
| WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | CAMBRIDGE, MA | $250,000 | 2025 | RESEARCH PROJECT |
| DANA-FARBER CANCER INSTITUTE | BOSTON, MA | $250,000 | 2025 | RESEARCH PROJECT |
| PRESIDENT AND FELLOWS OF HARVARD COLLEGE | BOSTON, MA | $250,000 | 2025 | RESEARCH PROJECT |
| COLUMBIA UNIVERSITY | NEW YORK, NY | $250,000 | 2025 | RESEARCH PROJECT |
| WHITE PLAINS HOSPITAL | WHITE PLAINS, NY | $250,000 | 2025 | GENERAL PURPOSE |
| CLEVELAND CLINIC FOUNDATION | CLEVELAND, OH | $250,000 | 2025 | RESEARCH PROJECT |
| CLEVELAND CLINIC FOUNDATION | CLEVELAND, OH | $250,000 | 2025 | RESEARCH PROJECT |
| CASE WESTERN RESERVE UNIVERSITY | CLEVELAND, OH | $250,000 | 2025 | RESEARCH PROJECT |
| DANA-FARBER CANCER INSTITUTE | BOSTON, MA | $250,000 | 2025 | RESEARCH PROJECT |
| ROCKEFELLER UNIVERSITY | NEW YORK, NY | $250,000 | 2025 | RESEARCH PROJECT |
| THE WISTAR INSTITUTE | PHILADELPHIA, PA | $250,000 | 2025 | RESEARCH PROJECT |
| UNIVERSITY OF MICHIGAN | ANN ARBOR, MI | $249,984 | 2025 | RESEARCH PROJECT |
| BOSTON COLLEGE | CHESTNUT HILL, MA | $249,935 | 2025 | RESEARCH PROJECT |
| ICAHN SCHOOL OF MEDICINE AT MT SINAI | NEW YORK, NY | $247,097 | 2025 | RESEARCH PROJECT |
| WEILL CORNELL MEDICAL COLLEGE | NEW YORK, NY | $246,187 | 2025 | RESEARCH PROJECT |
| WEILL CORNELL MEDICAL COLLEGE | NEW YORK, NY | $243,987 | 2025 | RESEARCH PROJECT |
| DUKE UNIVERSITY | DURHAM, NC | $241,950 | 2025 | RESEARCH PROJECT |
| PRESIDENT AND FELLOWS OF HARVARD COLLEGE | BOSTON, MA | $240,000 | 2025 | RESEARCH PROJECT |
| MASSACHUSETTS GENERAL HOSPITAL | BOSTON, MA | $240,000 | 2025 | RESEARCH PROJECT |
| DANA-FARBER CANCER INSTITUTE | BOSTON, MA | $240,000 | 2025 | RESEARCH PROJECT |
| COLUMBIA UNIVERSITY | NEW YORK, NY | $238,595 | 2025 | RESEARCH PROJECT |
| SALK INSTITUTE FOR BIOLOGICAL STUDIES | LA JOLLA, CA | $234,692 | 2025 | RESEARCH PROJECT |
| TUFTS COLLEGE | MEDFORD, MA | $233,522 | 2025 | RESEARCH PROJECT |
| PRESIDENT AND FELLOWS OF HARVARD COLLEGE | BOSTON, MA | $233,333 | 2025 | RESEARCH PROJECT |
| PRESIDENT AND FELLOWS OF HARVARD COLLEGE | BOSTON, MA | $233,333 | 2025 | RESEARCH PROJECT |
| YALE UNIVERSITY | NEW HAVEN, CT | $233,333 | 2025 | RESEARCH PROJECT |
| LELAND STANFORD JUNIOR UNIVERSITY | STANFORD, CA | $233,333 | 2025 | RESEARCH PROJECT |
| UNIVERSITY OF CALIFORNIA LOS ANGELES | PASADENA, CA | $233,333 | 2025 | RESEARCH PROJECT |
| DANA-FARBER CANCER INSTITUTE | BOSTON, MA | $233,333 | 2025 | RESEARCH PROJECT |
| CLEVELAND CLINIC FOUNDATION | CLEVELAND, OH | $233,224 | 2025 | RESEARCH PROJECT |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | PASADENA, CA | $233,153 | 2025 | RESEARCH PROJECT |
| UNIVERSITY OF CALIFORNIA BERKELEY | BERKELEY, CA | $233,000 | 2025 | RESEARCH PROJECT |
| CUNY ADVANCED SCIENCE RESEARCH CENTER | NEW YORK, NY | $231,937 | 2025 | RESEARCH PROJECT |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | BOSTON, MA | $230,869 | 2025 | RESEARCH PROJECT |
| LELAND STANFORD JUNIOR UNIVERSITY | STANFORD, CA | $230,461 | 2025 | RESEARCH PROJECT |
| YALE UNIVERSITY | NEW HAVEN, CT | $228,252 | 2025 | RESEARCH PROJECT |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | PASADENA, CA | $227,488 | 2025 | RESEARCH PROJECT |
| SALK INSTITUTE FOR BIOLOGICAL STUDIES | LA JOLLA, CA | $227,328 | 2025 | RESEARCH PROJECT |
| DANA-FARBER CANCER INSTITUTE | BOSTON, MA | $225,000 | 2025 | RESEARCH PROJECT |
| DANA-FARBER CANCER INSTITUTE | BOSTON, MA | $225,000 | 2025 | RESEARCH PROJECT |
| CHILDREN'S HOSPITAL CORP (BOSTON CHILDREN'S HOSPITAL) | BOSTON, MA | $225,000 | 2025 | RESEARCH PROJECT |
YALE UNIVERSITY
$268,534RESEARCH PROJECT
LELAND STANFORD JUNIOR UNIVERSITY
$259,200RESEARCH PROJECT
CHILDREN'S HOSPITAL CORP (BOSTON CHILDREN'S HOSPITAL)
RESEARCH PROJECT
CHILDREN'S HOSPITAL CORP (BOSTON CHILDREN'S HOSPITAL)
$253,000RESEARCH PROJECT
COLUMBIA UNIVERSITY
$250,000RESEARCH PROJECT
WHITE PLAINS HOSPITAL
$250,000GENERAL PURPOSE
CLEVELAND CLINIC FOUNDATION
$250,000RESEARCH PROJECT
CLEVELAND CLINIC FOUNDATION
$250,000RESEARCH PROJECT
CASE WESTERN RESERVE UNIVERSITY
$250,000RESEARCH PROJECT
THE WISTAR INSTITUTE
$250,000RESEARCH PROJECT
UNIVERSITY OF MICHIGAN
$249,984RESEARCH PROJECT
BOSTON COLLEGE
$249,935RESEARCH PROJECT
MASSACHUSETTS GENERAL HOSPITAL
$240,000RESEARCH PROJECT
COLUMBIA UNIVERSITY
$238,595RESEARCH PROJECT
SALK INSTITUTE FOR BIOLOGICAL STUDIES
$234,692RESEARCH PROJECT
TUFTS COLLEGE
$233,522RESEARCH PROJECT
YALE UNIVERSITY
$233,333RESEARCH PROJECT
UNIVERSITY OF CALIFORNIA LOS ANGELES
$233,333RESEARCH PROJECT
CLEVELAND CLINIC FOUNDATION
$233,224RESEARCH PROJECT
UNIVERSITY OF CALIFORNIA BERKELEY
$233,000RESEARCH PROJECT
CUNY ADVANCED SCIENCE RESEARCH CENTER
$231,937RESEARCH PROJECT
YALE UNIVERSITY
$228,252RESEARCH PROJECT
SALK INSTITUTE FOR BIOLOGICAL STUDIES
$227,328RESEARCH PROJECT
CHILDREN'S HOSPITAL CORP (BOSTON CHILDREN'S HOSPITAL)
$225,000RESEARCH PROJECT