Hope for Depression Research Foundation C/O Gruss & Co
ActiveMedical Research
About Hope for Depression Research Foundation C/O Gruss & Co
The mission of the Hope for Depression Research Foundation (HDRF) is to fund the most innovative neuroscience research into the origins, diagnosis, treatment and prevention of depression and its related mood disorders – bipolar disorder, postpartum depression, post-traumatic stress disorder, anxiety disorder and suicide. HDRF also raises awareness of depression as a medical illness and educates the public to help remove stigma. Every dollar raised goes directly to research.
Focus Areas
DepressionNeuroscienceBipolar disorderPostpartum depressionPost-traumatic stress disorder (PTSD)Anxiety disordersSuicide preventionClinical trials / new treatment developmentResearch data sharing
Who They Fund
people living with depressionmental health patients
About Hope for Depression Research Foundation C/O Gruss & Co
Hope for Depression Research Foundation C/o Gruss & Co LLC backs neuroscience work aimed at depression and related mood disorders, with a grantmaking pattern that centers on collaborative research and the move from preclinical findings toward new treatments. Its current strategy includes the Depression Task Force and clinical trial initiatives designed to accelerate promising ideas into patient testing. Recent grants show support for established medical research institutions, including Research Foundation for Mental Hygiene Inc in Menands, New York, and Icahn School of Medicine at Mount Sinai in New York, New York. The foundation also funds work at the University of Michigan in Ann Arbor and Duke University in Durham, reflecting a portfolio built around university-led research teams. The foundation’s mission extends beyond depression alone to bipolar disorder, postpartum depression, post-traumatic stress disorder, anxiety disorder, and suicide. It also says it raises awareness of depression as a medical illness and works to educate the public to reduce stigma. That combination of research funding and public education gives the foundation a clear focus: support studies that can improve understanding, diagnosis, treatment, and prevention of mood disorders. Every dollar raised goes directly to research, according to the foundation’s description.
What Hope for Depression Research Foundation C/O Gruss & Co Funds
A major share of the foundation’s work supports depression research through university and medical-school partnerships. In 2024, it gave $1,175,490 to Icahn School of Medicine at Mount Sinai in New York, New York, and in 2023 it gave $1,007,567 to the same institution for depression research. It also supports collaborative neuroscience projects. The Research Foundation for Mental Hygiene Inc in Menands, New York received $2,099,449 in 2023 and $1,360,993 in 2024, both labeled depression research. The foundation funds research at multiple institutions studying treatment development and related mechanisms. Duke University in Durham, North Carolina received $383,631 in 2024 and $367,500 in 2023, while the University of Michigan in Ann Arbor received $875,774 in 2024 and $775,068 in 2023. Its portfolio also reaches into other academic centers, including Joan & Sanford I Weil Medical College of Cornell in New York, New York, which received grants in both 2023 and 2024 for depression research.
Financial Snapshot
Annual Giving
$3.7M
Total Assets
$39.4M
Total Revenue
$3.4M
Total Expenses
$7.3M
Typical Grant Size
Most grants fall between $217K and $975K, with a median of $398K.
25th Percentile
$217K
Median
$398K
75th Percentile
$975K
Geographic Reach
National6 states funded
Funding intensity
LowHigh
Headquarters
Leadership
AUDREY B GRUSS CHAIRMAN
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