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    5. Alpha-1 Foundation
    Alpha-1 Foundation logo

    Alpha-1 Foundation

    ActiveHealth CareMakes PRIs
    Miami, FLWebsite3055679888

    About Alpha-1 Foundation

    The Alpha-1 Foundation is committed to finding a cure for Alpha-1 Antitrypsin Deficiency and to improving the lives of people affected by Alpha-1 worldwide.

    Focus Areas

    Alpha-1 Antitrypsin Deficiency (AATD)Lung diseaseLiver diseaseClinical trials and therapeutic developmentBiobanking (DNA & tissue)Research training and career developmentPatient education and support

    Who They Fund

    people living with alpha-1 antitrypsin deficiencypatients' families and caregiversclinical researchers and trial investigatorsrare disease patient community

    Funding Style

    About Alpha-1 Foundation

    A defining feature of Alpha-1 Foundation Inc is its sustained support for research tied to Alpha-1 antitrypsin deficiency, including work that moves from early-stage ideas into clinical development. The foundation’s active programs include pilot and feasibility awards, career development awards, ethical, legal, and social issues grants, travel grants, and the therapeutic-development investment program known as The Alpha-1 Project. That mix shows a funder that supports both scientific infrastructure and the pipeline from hypothesis generation to therapy-oriented work. Recent grants illustrate that approach across major research institutions and medical centers. University of Florida received multiple awards across 2023 to 2025, including a $523,817 grant in 2025. Brigham & Women’s Hospital also appears repeatedly, with awards in 2024 and 2025, including $397,375 in 2025. Columbia University, Boston University, National Jewish Health, and Baylor College of Medicine are among other recipients, signaling a broad research network centered on Alpha-1-related lung and liver disease, translational research, and therapeutic development.

    What Alpha-1 Foundation Funds

    The foundation backs several connected lines of work around Alpha-1 antitrypsin deficiency. For therapeutic development, it uses The Alpha-1 Project to invest in pharmaceutical and biotech companies and tools that advance therapies for Alpha-1, including work tied to liver disease and COPD. It also supports investigator development and early research. John W. Walsh Career Development awards are designed to help researchers test new hypotheses or methods in AATD, while Pilot and Feasibility awards support one-year projects that generate preliminary data for larger studies. In addition, the foundation funds bioethical, legal, economic, and social research through its ELSI grants. Patient-facing support is part of the portfolio as well. Its stated focus areas include patient education and support, alongside research on lung disease, liver disease, biobanking, and clinical trials.

    How Alpha-1 Foundation Gives

    Typical grant size sits at $56,611 at the 25th percentile, $99,476 at the median, and $140,292 at the 75th percentile. The recent record shows repeated awards to the same institutions across multiple years, including several universities and hospitals that received grants in both 2023, 2024, and 2025. That pattern points to sustained research relationships rather than one-off support. The foundation is an operating grantmaker with program-related investments and a national geographic scope. Several active programs accept unsolicited applications, including in-cycle grants, pilot and feasibility awards, travel grants, and ELSI grants. The therapeutic-development investment program does not accept unsolicited applications.

    Financial Snapshot

    Annual Giving

    $1.8M

    Total Assets

    $47.5M

    Total Revenue

    $13.8M

    Total Expenses

    $14M

    Typical Grant Size

    Most grants fall between $57K and $140K, with a median of $99K.

    25th Percentile

    $57K

    Median

    $99K

    75th Percentile

    $140K

    Geographic Reach

    National15 states funded

    About 7% of grants go to recipients in MA.

    Funding intensity
    Low
    High
    Headquarters

    Leadership

    Scott Santarella

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    Privacy PolicyTerms of ServiceYour privacy choicesEnvironmental footprintSystem Status
    EIN (Tax ID): 65-0585415Latest Form 990: 2026Total assets: $47.5M4 filings on recordFind their full 990 filing →
    See If You're a Fit — FreeFree account · instant fit score · similar funders
    disease-focused medical research fundingsupport for clinical trialspatient education and support servicesadvocacy and policy engagementdata infrastructure (biobank/registry) funding

    Topics

    alpha-1 antitrypsin deficiency researchrare disease clinical trialspatient and caregiver educationbiobanking and patient registry developmentquality-of-life improvement interventions

    Where Alpha-1 Foundation Makes Grants

    Grantmaking is national and entirely U.S.-based in the recent record, with 44 grants to U.S. recipients. The top state by grant count is Illinois, though the foundation itself is headquartered in Miami, Florida. Recent awards land in research hubs such as Gainesville, Boston, New York, Los Angeles, Denver, Cambridge, Birmingham, Houston, and Rochester. Florida recipients account for 7% of grants, showing some in-state activity but a broader national spread.

    Frequently Asked Questions About Alpha-1 Foundation

    What kinds of projects does Alpha-1 Foundation Inc fund?

    It funds research and related work focused on Alpha-1 antitrypsin deficiency, including lung disease, liver disease, clinical trials, therapeutic development, biobanking, research training, patient education, and support. It also supports ethical, legal, and social issues research tied to genetic conditions.

    What is the typical grant size?

    Typical awards fall around $56,611 at the 25th percentile, $99,476 at the median, and $140,292 at the 75th percentile. Active programs also include smaller travel grants up to $1,000 and larger research awards up to $100,000.

    Does the foundation fund the same organizations more than once?

    Yes. The recent grants list shows repeated awards to the same institutions across multiple years, including University of Florida, Brigham & Women's Hospital, Columbia University, Boston University, National Jewish Health, and Baylor College of Medicine.

    How does the foundation support therapeutic development?

    Through The Alpha-1 Project, it invests in pharmaceutical and biotech companies and tools that advance therapies for Alpha-1. The program is tied to drug discovery and development and is not limited to a single region.

    Are applications accepted for any of its programs?

    Yes. Several active programs accept unsolicited applications, including the In-Cycle Grants Award Program, Pilot and Feasibility awards, Travel Grants, ELSI grants, and Career Development awards. The therapeutic-development investment program does not accept unsolicited applications.

    Latest 990 Filing

    2026

    Source: IRS Form 990-PF, fiscal year 2026.

    Open Grant Opportunities

    Current and upcoming funding from Alpha-1 Foundation that your nonprofit may be able to apply for.

    Open nowCloses Feb 12, 2027Award: $1K – $400K

    2025–2026 In‑Cycle Grants Award Program

    Alpha-1 Antitrypsin Deficiency researchlung diseaseliver disease+7 more

    Who can apply: Selected Letter of Intent submissions are invited to submit a full proposal. The Foundation does not accept LOIs or grant applications from pharmaceutical companies, biotechs, or industry for in-cycle grant programs, and such entities may not be collaborators on proposals.

    Deadline: July 2026 announcement; Letter of Intent due September 25, 2026; invitation to submit full applications November 27, 2026; grant applications due February 12, 2027; funding decisions in April 2027.

    View & apply
    Open nowRolling / open intakeAward: Up to $5K

    Alpha-1 Foundation Scientific Meeting Sponsorship

    Alpha-1 Antitrypsin DeficiencyScientific meetingsWorkshops+2 more

    Who can apply: The meeting must be relevant to Alpha-1 Deficiency and the Foundation’s mission. Applicants must contact the Grants Administration Manager before preparing and submitting an LOI.

    Deadline: Requests must be received at least two months before the anticipated meeting; timing otherwise varies.

    View & apply

    Track these deadlines, get reminders, and see how well your nonprofit fits — free with a Kindora account.

    Create a free account

    Deadlines and eligibility are summarized from public sources and may change — always confirm the details on the funder's official application page before applying.

    Recent Grants

    Most recent grants reported to the IRS.

    RecipientLocationAmountYearPurpose
    UNIVERSITY OF FLORIDAGAINSVILLE, FL$470,5492026RESEARCH
    REGENTS OF THE UNIV OF CALIFORNIADAVIS, CA$178,9442026RESEARCH
    BRIGHAM & WOMEN'S HOSPITAL INCBOSTON, MA$174,1252026RESEARCH
    BAYLOR COLLEGE OF MEDICINEHOUSTON, TX$174,0512026RESEARCH
    NATIONAL JEWISH HEALTHDENVER, CO$99,7232026RESEARCH
    UNIVERISTY OF CINCINNATICLEVELAND, OH$99,5002026RESEARCH
    CLEMSON UNIVERSITYCLEMSON, SC$99,4522026RESEARCH
    BOSTON MEDICAL CENTERBOSTON, MA$95,2672026RESEARCH
    THE UNIVERSITY OF TEXASAUSTIN, TX$74,0002026RESEARCH
    BOSTON UNIV OF INTERNAL MEDICINEBOSTON, MA$63,3682026RESEARCH
    UNIVERSITY OF COLORADODENVER, CO$52,5002026RESEARCH
    UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE INCKANSAS CITY, KS$48,0122026RESEARCH
    UNIVERSITY OF CHICAGOCHICAGO, IL$45,8942026RESEARCH
    CENTER FOR VETERANS RESEARCH AND EDUCATIONMINNEAPOLIS, MN$38,8372026RESEARCH
    TRUSTEES OF BOSTON UNIVERSITYBOSTON, MA$37,2502026RESEARCH
    COLUMBIA UNIVERSITYNEW YORK, NY$35,8452026RESEARCH
    UNIVERSITY OF UTAHSALT LAKE CITY, UT$10,4992026RESEARCH
    FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGYBETHESDA, MD$7,5002026RESEARCH
    GORDON RESEARCH CONFERENCESDENVER, CO$7,5002026RESEARCH
    University of FloridaGainesville, FL$523,8172025Research
    Brigham & Women's HospitalBoston, MA$397,3752025—
    Columbia UniversityNew York, NY$234,3752025—
    Regents of the University of California Los AngelesLos Angeles, CA$233,7492025Research
    Boston UniversityBoston, MA$185,6182025—
    University of AlabamaBirmingham, AL$124,5002025—
    Baylor College of MedicineHouston, TX$124,3502025—
    Boston Medical CenterBoston, MA$99,5002025—
    Clemson UniversityClemson, SC$99,4522025—
    University of ColoradoDenver, CO$70,0002025—
    University of ChicagoChicago, IL$62,1482025—
    National Jewish HealthDenver, CO$40,0002025—
    NORDWoburn, MA$30,0002025—
    University of Kansas Medical CenterKansas City, KS$16,0042025—
    University of FloridaGainesville, FL$457,3982024Research
    Brigham & Women's HospitalBoston, MA$199,0002024Research
    Boston UniversityBoston, MA$146,4332024Research
    Columbia UniversityNew York, NY$141,1672024Research
    National Jewish HealthDenver, CO$140,0002024Research
    Mass Inst of TechnologyCambridge, MA$124,7502024Research
    University of KentuckyLexington, KY$100,0002024Research
    Boston Medical CenterBoston, MA$99,5002024Research
    Northwestern UniversityChicago, IL$82,0002024Research
    University of AlabamaBirmingham, AL$74,5002024Research
    University of ColoradoDenver, CO$31,7392024Research
    Nat Org Rare DisordersDanbury, CT$25,0002024Patient support
    University of N CarolinaChapel Hill, NC$10,0002024Research
    Saint Louis UniversitySaint Louis, MO$5,6472024Research
    University of FloridaGainesville, FL$441,6152023Research
    Columbia UniversityNew York, NY$300,0002023Research
    National Jewish HealthDenver, CO$124,8732023Research

    UNIVERSITY OF FLORIDA

    $470,549
    GAINSVILLE, FL2026

    RESEARCH

    REGENTS OF THE UNIV OF CALIFORNIA

    $178,944
    DAVIS, CA2026

    RESEARCH

    BRIGHAM & WOMEN'S HOSPITAL INC

    $174,125
    BOSTON, MA2026

    RESEARCH

    BAYLOR COLLEGE OF MEDICINE

    $174,051
    HOUSTON, TX2026

    RESEARCH

    NATIONAL JEWISH HEALTH

    $99,723
    DENVER, CO2026

    RESEARCH

    UNIVERISTY OF CINCINNATI

    $99,500
    CLEVELAND, OH2026

    RESEARCH

    CLEMSON UNIVERSITY

    $99,452
    CLEMSON, SC2026

    RESEARCH

    BOSTON MEDICAL CENTER

    $95,267
    BOSTON, MA2026

    RESEARCH

    THE UNIVERSITY OF TEXAS

    $74,000
    AUSTIN, TX2026

    RESEARCH

    BOSTON UNIV OF INTERNAL MEDICINE

    $63,368
    BOSTON, MA2026

    RESEARCH

    UNIVERSITY OF COLORADO

    $52,500
    DENVER, CO2026

    RESEARCH

    UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE INC

    $48,012
    KANSAS CITY, KS2026

    RESEARCH

    UNIVERSITY OF CHICAGO

    $45,894
    CHICAGO, IL2026

    RESEARCH

    CENTER FOR VETERANS RESEARCH AND EDUCATION

    $38,837
    MINNEAPOLIS, MN2026

    RESEARCH

    TRUSTEES OF BOSTON UNIVERSITY

    $37,250
    BOSTON, MA2026

    RESEARCH

    COLUMBIA UNIVERSITY

    $35,845
    NEW YORK, NY2026

    RESEARCH

    UNIVERSITY OF UTAH

    $10,499
    SALT LAKE CITY, UT2026

    RESEARCH

    FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY

    $7,500
    BETHESDA, MD2026

    RESEARCH

    GORDON RESEARCH CONFERENCES

    $7,500
    DENVER, CO2026

    RESEARCH

    University of Florida

    $523,817
    Gainesville, FL2025

    Research

    Brigham & Women's Hospital

    $397,375
    Boston, MA2025

    Columbia University

    $234,375
    New York, NY2025

    Regents of the University of California Los Angeles

    $233,749
    Los Angeles, CA2025

    Research

    Boston University

    $185,618
    Boston, MA2025

    University of Alabama

    $124,500
    Birmingham, AL2025

    Baylor College of Medicine

    $124,350
    Houston, TX2025

    Boston Medical Center

    $99,500
    Boston, MA2025

    Clemson University

    $99,452
    Clemson, SC2025

    University of Colorado

    $70,000
    Denver, CO2025

    University of Chicago

    $62,148
    Chicago, IL2025

    National Jewish Health

    $40,000
    Denver, CO2025

    NORD

    $30,000
    Woburn, MA2025

    University of Kansas Medical Center

    $16,004
    Kansas City, KS2025

    University of Florida

    $457,398
    Gainesville, FL2024

    Research

    Brigham & Women's Hospital

    $199,000
    Boston, MA2024

    Research

    Boston University

    $146,433
    Boston, MA2024

    Research

    Columbia University

    $141,167
    New York, NY2024

    Research

    National Jewish Health

    $140,000
    Denver, CO2024

    Research

    Mass Inst of Technology

    $124,750
    Cambridge, MA2024

    Research

    University of Kentucky

    $100,000
    Lexington, KY2024

    Research

    Boston Medical Center

    $99,500
    Boston, MA2024

    Research

    Northwestern University

    $82,000
    Chicago, IL2024

    Research

    University of Alabama

    $74,500
    Birmingham, AL2024

    Research

    University of Colorado

    $31,739
    Denver, CO2024

    Research

    Nat Org Rare Disorders

    $25,000
    Danbury, CT2024

    Patient support

    University of N Carolina

    $10,000
    Chapel Hill, NC2024

    Research

    Saint Louis University

    $5,647
    Saint Louis, MO2024

    Research

    University of Florida

    $441,615
    Gainesville, FL2023

    Research

    Columbia University

    $300,000
    New York, NY2023

    Research

    National Jewish Health

    $124,873
    Denver, CO2023

    Research