About City of Hope
To provide compassionate medical care to people with cancer, diabetes and other life‑threatening illnesses and transforming the future of cancer care by unifying the branches of biomedical research, treatment and academia.
Focus Areas
Cancer research and treatmentDiabetes care and researchHIV/AIDS careStem cell biology and regenerative medicineClinical trials and translational medicinePrecision medicine / genomics
Funding Style
operating supportunrestricted/general operating supportorganizational capacity
Topics
nonprofit sustainabilityinfrastructure and overhead support
About City of Hope
City of Hope’s recent giving is dominated by large operating support grants to its own research and care institutions in Duarte, including $48,529,658 to the Beckman Research Institute of the COH in 2023 and $41,830,802 to the City of Hope National Medical Center in 2025. That pattern fits the organization’s stated mission: providing compassionate medical care for people with cancer, diabetes, and other life-threatening illnesses while advancing cancer care through research, treatment, and academia. The foundation’s grantmaking is closely tied to its medical and research system rather than a broad external portfolio. Across the latest grants list, the same core institutions appear repeatedly, with Beckman Research Institute and City of Hope National Medical Center receiving the largest awards. The foundation also supports the Translational Genomics Research Institute, indicating attention to genomics-linked research within its broader biomedical agenda. Grants in the recent file are all operating support, and the recipient pool is entirely U.S.-based. City of Hope’s leadership is listed as Robert W Stone, President & CEO.
What City of Hope Funds
Cancer research and treatment is central to City of Hope’s grantmaking. The latest grants include $46,623,682 in 2025 to the Beckman Research Institute of the City Of Hope for operating support and $40,267,371 in 2024 to the City of Hope National Medical Center for operating support, both tied to the organization’s medical and research system. The foundation also supports translational genomics. In 2024, it gave $2,002,719 to The Translational Genomics Research Institute for operating support, followed by smaller awards in 2025 and 2023 to the same recipient. Its broader mission references diabetes care and research, HIV/AIDS care, stem cell biology and regenerative medicine, clinical trials and translational medicine, and precision medicine / genomics. The recent grants list does not show separate external awards in those areas, but it does show continuing support for biomedical infrastructure through operating grants.
How City of Hope Gives
The recent grant sizes are highly skewed: p25 is $320,938, the median is $26,214,443, and p75 is $42,857,122. That reflects a pattern of very large operating grants alongside a few much smaller awards. The grants list also shows repeated support for the same recipients across 2023, 2024, and 2025, especially within City of Hope’s own system. City of Hope makes program-related investments and gives locally; the latest grants are all operating support. The foundation’s portfolio is institution-centered rather than grant-by-grant project funding.
Financial Snapshot
Annual Giving
$115.7M
Total Assets
$4.7B
Total Revenue
$369.8M
Total Expenses
$235.5M
Typical Grant Size
Most grants fall between $321K and $42.9M, with a median of $26.2M.
25th Percentile
$321K
Median
$26.2M
75th Percentile
$42.9M
Geographic Reach
Local2 states funded
Funding intensity
LowHigh
Headquarters
Leadership
Robert W Stone
President & CEO
Accepts unsolicited proposals
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