The Shanahan Family Charitable Foundation concentrates its giving on biomedical and neuroscience research—particularly Alzheimer’s drug discovery and data science—alongside substantial investments in higher education (with a STEM emphasis) and independent/community media. It also makes targeted community-environment and youth-development gifts. Many large, multi-year grants go to a small set of repeat institutional partners, while mid-sized gifts support place-based community initiatives and youth programs.
The Shanahan Family Charitable Foundation’s clearest pattern is large, repeated support for Alzheimer’s drug discovery and brain-health research. In the recent-grants list, the biggest awards go to the Alzheimer’s Drug Discovery Foundation and the Alzheimer’s Disease Data Initiative, with multiyear general-purpose grants that show a sustained emphasis on research infrastructure as well as discovery. That biomedical focus sits alongside another major line of giving: higher education, especially institutions tied to STEM training and research. Harvey Mudd College appears repeatedly among the larger grants, and the foundation also supports research-heavy universities and institutes such as the Allen Institute, the Children’s Hospital of Philadelphia, Tufts University, and the University of Pennsylvania. The foundation’s giving is not limited to science and education. It also supports independent media through the Independent Media Initiative and a related Community Partners grant, while directing place-based support to community and environmental work through Cobbs Creek Restoration and Community Foundation. Across the recent record, the foundation favors institutional grantees and often returns to the same partners over multiple years.
Biomedical research is the foundation’s central theme. It gave $2,676,667 to the Alzheimer’s Drug Discovery Foundation in 2025 for general purpose support, and it also backed the Alzheimer’s Disease Data Initiative with annual $1,550,000 grants in 2023, 2024, and 2025. Data science and neuroscience appear together in its support for the Allen Institute, including a $2,110,308 grant in 2025, and in the Shanahan Foundation Fellowship at the Interface of Data and Neuroscience. Higher education is another recurring area. The foundation gave $2,136,524 to Harvey Mudd College in 2025 for general purpose support, reflecting a broader STEM-oriented university pattern. It also funded Tufts University and Stanford University through sizable general-purpose grants. Beyond research and education, the foundation supports independent media through the Independent Media Initiative and related intermediaries, and it has made place-based community and environmental grants to Cobbs Creek Restoration and Community Foundation.
$20.7M
$439.5M
$24.9M
$23.5M
Most grants fall between $50K and $500K, with a median of $114K.
25th Percentile
$50K
Median
$114K
75th Percentile
$500K
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Concentrated, high-dollar philanthropy with repeated multi-grant support to a handful of flagship science and academic institutions, supplemented by mid-sized, place-based grants to community nonprofits and media initiatives; mix of large flagship gifts and strategic smaller donations.
Notable grantees: Alzheimer's Drug Discovery Foundation, Harvey Mudd College, Allen Institute, Independent Media Initiative, Cobbs Creek Restoration and Community Foundation
Typical grant size is mid- to large-scale: the p25 is $50,000, the median is $113,572, and the p75 reaches $500,000. The recent record shows repeated support to the same institutions across multiple years, especially in medical research, neuroscience, and higher education, which points to ongoing relationships rather than one-off awards. The foundation is a regular funder rather than a donor-advised fund. It also makes invitation-only grants through its general grantmaking and does not accept unsolicited full proposals, although organizations may submit a one-page letter of inquiry by email for that channel. The grant list is dominated by general-purpose support.
Giving is national, with all recent grants in the United States. California is the top state by grant count, and 29% of grants go to recipients in the foundation’s headquarters state. Recent recipient locations include New York, NY; Claremont, CA; Seattle, WA; Philadelphia, PA; Kirkland, WA; Austin, TX; Conshohocken, PA; Los Angeles, CA; Stanford, CA; and Medford, MA. The pattern shows broad U.S. reach with repeated concentration in research and education hubs.
Its recent grantmaking centers on Alzheimer’s and brain-health research, biomedical and neuroscience institutions, STEM-focused higher education, and independent media. It also makes targeted community and environmental gifts, including support tied to Cobbs Creek restoration.
Yes. Several recipients appear across multiple years, including the Alzheimer’s Drug Discovery Foundation, the Alzheimer’s Disease Data Initiative, the Allen Institute, Harvey Mudd College, Tufts University, the University of Pennsylvania, and Cobbs Creek Restoration and Community Foundation.
The grant-size distribution shows a p25 of $50,000, a median of $113,572, and a p75 of $500,000. The recent grants list also includes several awards above $1 million, especially in research and higher education.
Its general Shanahan Family Foundation grantmaking is invitation only and does not accept unsolicited full proposals. Organizations may submit a one-page letter of inquiry by email for that channel. Some supported initiatives are listed separately as accepting unsolicited applications.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| Alzheimer's Drug Discovery Foundati | New York, NY | $2,676,667 | 2025 | General Purpose |
| Harvey Mudd College | Claremont, CA | $2,136,524 | 2025 | General Purpose |
| Allen Institute | Seattle, WA | $2,110,308 | 2025 | General Purpose |
| Children's Hospital of Philadelphia | Philadelphia, PA | $1,663,332 | 2025 | General Purpose |
| Alzheimer's Disease Data Initiative | Kirkland, WA | $1,550,000 | 2025 | GENERAL PURPOSE |
| Independent Media Initiative | Austin, TX | $1,200,000 | 2025 | General Purpose |
| Cobbs Creek Restoration and Comm Fd | Conshohocken, PA | $1,184,571 | 2025 | GENERAL PURPOSE |
| Tufts University | Medford, MA | $910,116 | 2025 | General Purpose |
| University of Pennsylvania | Philadelphia, PA | $700,000 | 2025 | General Purpose |
| St Margaret's Episcopal School | San Juan Capistrano, CA | $450,000 | 2025 | General Purpose |
| Stanford University | Stanford, CA | $420,000 | 2025 | General Purpose |
| University of California Berkeley F | Berkeley, CA | $389,049 | 2025 | General Purpose |
| The Episcopal Academy | Newtown Square, PA | $365,341 | 2025 | General Purpose |
| Ocean Institute | Dana Point, CA | $300,000 | 2025 | General Purpose |
| Children's Hospital of Orange Count | Orange, CA | $300,000 | 2025 | General Purpose |
| Northeastern University | Boston, MA | $300,000 | 2025 | General Purpose |
| Last Mile Education Fund | Lafayette, CO | $250,000 | 2025 | General Purpose |
| Ohio State University Foundation | Columbus, OH | $250,000 | 2025 | General Purpose |
| Research Theory | Austin, TX | $250,000 | 2025 | General Purpose |
| Work to Ride | Philadelphia, PA | $200,000 | 2025 | General Purpose |
| Fannie and John Hertz Foundation | Livermore, CA | $150,000 | 2025 | General Purpose |
| United Friends of the Children | Los Angeles, CA | $118,000 | 2025 | General Purpose |
| Cora Services Inc | Philadelphia, PA | $100,000 | 2025 | General Purpose |
| Desert Aids Project | Palm Springs, CA | $100,000 | 2025 | General Purpose |
| Canine Companions for Independence | Oceanside, CA | $100,000 | 2025 | General Purpose |
| K9s for Warriors | Ponte Vedra, FL | $100,000 | 2025 | General Purpose |
| Keewaydin Foundation | Salisbury, VT | $75,000 | 2025 | General Purpose |
| Graham Windham | Brooklyn, NY | $50,000 | 2025 | General Purpose |
| Computing Research Association | Washington, DC | $50,000 | 2025 | General Purpose |
| The Franklin Institute | Philadelphia, PA | $50,000 | 2025 | General Purpose |
| Community Backstop | Media, PA | $50,000 | 2025 | General Purpose |
| Thomas Jefferson University | Philadelphia, PA | $50,000 | 2025 | General Purpose |
| Providence Animal Center | Media, PA | $25,000 | 2025 | GENERAL PURPOSE |
| Peter's Place | Radnor, PA | $25,000 | 2025 | General Purpose |
| University of Texas Foundation | Austin, TX | $19,000 | 2025 | General Purpose |
| Mountain Community Hospital Foundat | Lake Arrowhead, CA | $18,625 | 2025 | General Purpose |
| Friends of Golf | Tarzana, CA | $15,000 | 2025 | General Purpose |
| Dickinson College | Carlisle, PA | $10,000 | 2025 | General Purpose |
| Westside German Shepherd Rescue | Los Angeles, CA | $10,000 | 2025 | General Purpose |
| Colbys Crew Rescue | Keswick, VA | $8,000 | 2025 | General Purpose |
| Race for Life Inc | Annapolis, MD | $7,000 | 2025 | General Purpose |
| American Prairie Foundation | Bozeman, MT | $5,000 | 2025 | General Purpose |
| National Sporting Library Inc | Middleburg, VA | $5,000 | 2025 | General Purpose |
| Brandywine Valley SPCA | West Chester, PA | $4,000 | 2025 | General Purpose |
| Planned Parenthood | New York, NY | $3,000 | 2025 | General Purpose |
| First Page | Peoria, AZ | $1,000 | 2025 | General Purpose |
| Harvard College | Cambridge, MA | $1,000 | 2025 | General Purpose |
| Alzheimer's Drug Discovery Foundati | New York, NY | $2,716,667 | 2024 | General Purpose |
| Harvey Mudd College | Claremont, CA | $2,231,908 | 2024 | GENERAL PURPOSE |
| Allen Institute | Seattle, WA | $2,105,141 | 2024 | General Purpose |
Alzheimer's Disease Data Initiative
$1,550,000GENERAL PURPOSE
Independent Media Initiative
General Purpose
Cobbs Creek Restoration and Comm Fd
$1,184,571GENERAL PURPOSE
Tufts University
$910,116General Purpose
St Margaret's Episcopal School
$450,000General Purpose
Stanford University
$420,000General Purpose
University of California Berkeley F
$389,049General Purpose
Children's Hospital of Orange Count
$300,000General Purpose
Ohio State University Foundation
$250,000General Purpose
Research Theory
$250,000General Purpose
Desert Aids Project
$100,000General Purpose
Canine Companions for Independence
$100,000General Purpose
Computing Research Association
$50,000General Purpose
Community Backstop
$50,000General Purpose
Thomas Jefferson University
$50,000General Purpose
Providence Animal Center
$25,000GENERAL PURPOSE
Mountain Community Hospital Foundat
$18,625General Purpose
Friends of Golf
$15,000General Purpose
Dickinson College
$10,000General Purpose
Westside German Shepherd Rescue
$10,000General Purpose
Race for Life Inc
$7,000General Purpose
Planned Parenthood
$3,000General Purpose
First Page
$1,000General Purpose
Harvard College
$1,000General Purpose