What kinds of work does Open Molecular Software Foundation support?

It supports computational molecular sciences, open source scientific software, protein structure prediction and design, free energy methods and alchemical calculations, and community infrastructure and governance. The active programs also emphasize software infrastructure, reproducibility, FAIR practices, interoperability, and maintainer support.

Does Open Molecular Software Foundation accept unsolicited applications?

Yes, at least some programs do. The OMSF Hosted Projects / Fiscal Sponsorship program accepts unsolicited requests, and the OMSF Grant Program is also marked as accepting unsolicited applications. Other listed programs, including the NSF POSE-related projects and Rosetta POSE, do not accept unsolicited applications.

What is the typical grant size?

Among the recent grants provided, the 25th percentile is $7,069, the median is $33,761, and the 75th percentile is $249,011. The distribution includes one much larger grant of $863,000, so the average would not describe the pattern well.

Which organizations received recent grants?

Recent grants went to Rosetta Commons Foundation, UC Irvine, Johns Hopkins University, and Arizona State University. The awards covered software platform development, research, and open-source ecosystem development.

Is the foundation focused on one geography?

Its program descriptions are global, and the recent-grants list includes only U.S. recipients. The listed recipient cities are Baltimore, Irvine, and Tempe, with Baltimore appearing twice.

Open Molecular Software Foundation

ActivePublic CharityScience & Technology

Davis, CAWebsiteEIN: 86-25366641 filings on record

About Open Molecular Software Foundation

Advance humanity’s ability to understand and shape the physical world through open technologies.

Focus Areas

computational molecular sciencesopen source scientific softwarecomputational chemistryprotein structure prediction and designfree energy methods / alchemical calculationscommunity infrastructure and governance

Who They Fund

open-source projects and communitiessoftware developers and maintainersorganizations relying on open-source software (nonprofits, public sector, startups)

Funding Style

infrastructure/platform developmentecosystem building

About Open Molecular Software Foundation

A single $863,000 grant to Rosetta Commons Foundation anchored the Open Molecular Software Foundation’s most recent giving and points to its central role in open scientific software. The foundation funds computational molecular sciences, with grants that support software platform development, research, and open-source ecosystem work rather than individuals or program-related investments. Its active programs show two related approaches: direct grantmaking through the OMSF Grant Program and fiscally sponsored support for hosted projects, where the foundation provides back-office services, HR support, strategic advising, fundraising assistance, event and fellowship support, and governance guidance. Recent awards also show that the foundation works with universities as well as open-source communities. UC Irvine received $35,000 for research, Johns Hopkins University received $32,522 for research, and Arizona State University received $7,069 for open-source ecosystem development. Across these grants, the foundation’s activity centers on building the infrastructure and community conditions needed for molecular science software to be maintained and extended over time.

What Open Molecular Software Foundation Funds

In computational molecular sciences, the foundation’s grantmaking supports both software and the people maintaining it. One recent award gave $35,000 to UC Irvine for research, while another gave $32,522 to Johns Hopkins University for research, showing that academic collaborators are part of its portfolio. The foundation also funded Arizona State University with $7,069 for open-source ecosystem development, which aligns with its stated emphasis on open source scientific software and ecosystem building. Beyond direct grants, OMSF’s hosted-project model adds operational support for open-source communities through accounting, contracts, insurance, HR, strategic advising, fundraising assistance, and governance guidance. Its active programs also point to work in reproducibility, FAIR practices, interoperability, and community infrastructure.

How Open Molecular Software Foundation Gives

The recent grant sizes are highly skewed: the 25th percentile is $7,069, the median is $33,761, and the 75th percentile is $249,011. One grant of $863,000 sits far above the rest. The foundation is a public charity and a regular funder, not a DAF or individual-giving vehicle. Its active programs show both recurring grantmaking and structured support for hosted projects, and one of those programs explicitly accepts unsolicited applications. The recent-grants list includes only U.S. recipients, but the foundation’s program geography is described as global.

Financial Snapshot

Annual Giving

$938K

Total Assets

$3.5M

Total Revenue

$5.4M

Total Expenses

$5.3M

Geographic Reach

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Recipient	Location	Amount	Year	Purpose
Rosetta Commons Foundation	Baltimore, MD	$863,000	2025	Software Platform Development
UC Irvine	Irvine, CA	$35,000	2025	Research
Johns Hopkins University	Baltimore, MD	$32,522	2025	Research
Arizona State University	Tempe, CA	$7,069	2025	Open Source Ecosystem Development

Open Molecular Software Foundation

About Open Molecular Software Foundation

Focus Areas

Who They Fund

Funding Style

About Open Molecular Software Foundation

What Open Molecular Software Foundation Funds

How Open Molecular Software Foundation Gives

Financial Snapshot

Geographic Reach

Deep Analysis

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Topics

Where Open Molecular Software Foundation Makes Grants

Frequently Asked Questions About Open Molecular Software Foundation

What kinds of work does Open Molecular Software Foundation support?

Does Open Molecular Software Foundation accept unsolicited applications?

What is the typical grant size?

Which organizations received recent grants?

Is the foundation focused on one geography?

Recent Grants

Open Grant Opportunities

OMSF Hosted Projects / Fiscal Sponsorship

Open Molecular Software Foundation

About Open Molecular Software Foundation

Focus Areas

Who They Fund

Funding Style

About Open Molecular Software Foundation

What Open Molecular Software Foundation Funds

How Open Molecular Software Foundation Gives

Financial Snapshot

Geographic Reach

Unlock Deep Analysis

See Similar Funders

Want a Personalized Pitch for Open Molecular Software Foundation?

The Grant Brief

Topics

Where Open Molecular Software Foundation Makes Grants

Frequently Asked Questions About Open Molecular Software Foundation

What kinds of work does Open Molecular Software Foundation support?

Does Open Molecular Software Foundation accept unsolicited applications?

What is the typical grant size?

Which organizations received recent grants?

Is the foundation focused on one geography?

Recent Grants

Open Grant Opportunities

OMSF Hosted Projects / Fiscal Sponsorship