The Michel & Claire Gudefin Family Foundation directs the bulk of its giving to medical research and disease-focused national charities—especially cancer and Alzheimer’s research—while also making targeted local investments in education-to-career and scholarship programs in Naples, FL. Grants are primarily unrestricted operating support and tend to be large, multi-thousand-dollar gifts to a small set of organizations, with several repeat awards to the same national biomedical nonprofits.
Michel & Claire Gudefin Family Foundation Inc. centers much of its giving on medical research and disease-focused charities, with the American Cancer Society appearing repeatedly at the top of its recent grant list. The foundation also backs Alzheimer’s research organizations, including Alzheimers Disease Research Foundation and Cure Alzheimer’s Fund, through large operating grants. Beyond national health philanthropy, it supports Naples-area education-to-career and scholarship efforts, along with local nonprofit operations in southwest Florida. Its recent record shows a preference for substantial awards rather than many small gifts. The largest grant in the list went to the American Cancer Society, and the same organization received multiple awards across 2024 and 2025. Repeated support also appears for Cure Alzheimer’s Fund, suggesting an ongoing relationship with select research nonprofits. In Naples, the foundation has funded Learn2earn Charitable Foundation and the Rotary Club of Naples Charitable Foundation, tying local giving to workforce pathways and scholarship programs. Operating support is the dominant grant purpose across the portfolio, including gifts to St Matthew's House, National Alliance on Mental Illness, Homes for Our Troops, St Jude Children's Research Hospital, and Guadalupe Center.
Cancer research and patient support is a clear priority. The foundation gave $500,000 to the American Cancer Society in 2025, then followed with another $495,000 award the same year and a $475,000 grant in 2024, all for operating support. Alzheimer’s and dementia research is another major theme. It awarded $400,000 to Alzheimers Disease Research Foundation in 2025 and $350,000 to Cure Alzheimer’s Fund in 2025, after a $350,000 grant to the same funder in 2024. In Naples, the foundation has backed education-to-career and scholarship programs. It gave $175,000 to Learn2earn Charitable Foundation for operating support and $150,000 to Rotary Club of Naples Charitable Foundation for the Learn2Earn scholarship program in both 2024 and 2025. The foundation also supports nonprofit capacity through operating grants, including $95,000 awards to National Alliance on Mental Illness in 2024 and 2025.
$3M
$30.8M
$1.7M
$1.8M
Most grants fall between $12K and $130K, with a median of $43K.
25th Percentile
$12K
Median
$43K
75th Percentile
$130K
Sign up for a free Kindora account to access AI-generated insights into this funder's giving patterns, decision-makers, and fit signals.
Get Started FreeFree Kindora accounts unlock side-by-side comparisons with foundations that share this funder's focus areas and giving profile.
Get Started FreeSign up free to see how well your nonprofit fits this funder, get an AI-generated pitch, and unlock similar foundations.
Concentrated, high-dollar grants with repeat funding to a few national medical research charities and selective local grants; predominantly unrestricted operating support rather than many small or one-off donations.
Notable grantees: American Cancer Society, Cure Alzheimer’s Fund, Alzheimer’s Disease Research Foundation, Learn2Earn Charitable Foundation, Rotary Club of Naples Charitable Foundation
Typical grant sizes are broad but centered on substantial awards: the 25th percentile is $12,000, the median is $42,500, and the 75th percentile is $130,000. Recent grants include multiple repeat awards to the same organizations across 2024 and 2025, which points to ongoing relationships rather than one-off gifts. The pattern also skews toward operating support, with only a few grants labeled for a specific program or research council. The foundation’s annual grants total $4,445,000, and it funds individuals as well as organizations.
The foundation gives nationally, with all recent grants in the United States. Massachusetts appears most often among recipient locations, while 33% of grants go to recipients in Florida, the headquarters state. Recent recipients also cluster in Atlanta, Wellesley Hills, Naples, Arlington, and Taunton. Outside Florida, the recipient map includes recurring health and research grantees in Massachusetts and other U.S. cities rather than any non-U.S. country.
Its recent grants emphasize medical research and disease-focused charities, especially cancer and Alzheimer’s. The list also includes Naples-area education-to-career and scholarship support, plus operating support for local and national nonprofits in mental health, housing, pediatric care, child abuse prevention, and community services.
Yes. Several recipients appear in multiple years, including American Cancer Society in 2024 and 2025, Cure Alzheimer’s Fund in 2024 and 2025, St Matthew's House in 2024 and 2025, and Homes for Our Troops in 2024 and 2025.
The middle of the distribution is relatively large: the 25th percentile is $12,000, the median grant is $42,500, and the 75th percentile is $130,000. Recent awards also include several six-figure grants, especially for cancer and Alzheimer’s-related organizations.
No. Although 33% of grants go to recipients in Florida, the foundation gives nationally. Recent grants go to organizations in Massachusetts, Georgia, Virginia, Tennessee, Illinois, Maine, and Connecticut, alongside Florida recipients in Naples and Immokalee.
Operating support is the most common label in the recent grant list. A smaller number of awards are directed to specific purposes such as the Learn2Earn scholarship program and a research council grant to the American Cancer Society.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| AMERICAN CANCER SOCIETY | ATLANTA, GA | $500,000 | 2025 | OPERATING SUPPORT |
| AMERICAN CANCER SOCIETY | ATLANTA, GA | $495,000 | 2025 | OPERATING SUPPORT |
| ALZHEIMERS DISEASE RESEARCH FOUNDATION | WELLESLEY HILLS, MA | $400,000 | 2025 | OPERATING SUPPORT |
| CURE ALZHEIMER'S FUND | WELLESLEY HILLS, MA | $350,000 | 2025 | OPERATING SUPPORT |
| LEARN2EARN CHARITABLE FOUNDATION | NAPLES, FL | $175,000 | 2025 | OPERATING SUPPORT |
| ROTARY CLUB OF NAPLES CHARITABLE FOUNDATION | NAPLES, FL | $150,000 | 2025 | LEARN2EARN SCHOLARSHIP PROGRAM |
| ST MATTHEW'S HOUSE | NAPLES, FL | $140,000 | 2025 | OPERATING SUPPORT |
| ST MATTHEW'S HOUSE | NAPLES, FL | $130,000 | 2025 | OPERATING SUPPORT |
| NATIONAL ALLIANCE ON MENTAL ILLNESS | ARLINGTON, VA | $95,000 | 2025 | OPERATING SUPPORT |
| NATIONAL ALLIANCE ON MENTAL ILLNESS | ARLINGTON, VA | $95,000 | 2025 | OPERATING SUPPORT |
| HOMES FOR OUR TROOPS | TAUNTON, MA | $85,000 | 2025 | OPERATING SUPPORT |
| HOMES FOR OUR TROOPS | TAUNTON, MA | $85,000 | 2025 | OPERATING SUPPORT |
| ST JUDE CHILDREN'S RESEARCH HOSPITAL | MEMPHIS, TN | $55,000 | 2025 | OPERATING SUPPORT |
| ST JUDE CHILDREN'S RESEARCH HOSPITAL | MEMPHIS, TN | $55,000 | 2025 | OPERATING SUPPORT |
| GUADALUPE CENTER | IMMOKALEE, FL | $30,000 | 2025 | OPERATING SUPPORT |
| GUADALUPE CENTER | IMMOKALEE, FL | $30,000 | 2025 | OPERATING SUPPORT |
| PREVENT CHILD ABUSE AMERICA | CHICAGO, IL | $25,000 | 2025 | OPERATING SUPPORT |
| ABILIS | GREENWICH, CT | $12,000 | 2025 | OPERATING SUPPORT |
| APIFERA FARM INC | BREMEN, ME | $12,000 | 2025 | OPERATING SUPPORT |
| APIFERA FARM INC | BREMEN, ME | $12,000 | 2025 | OPERATING SUPPORT |
| ABILIS | GREENWICH, CT | $12,000 | 2025 | OPERATING SUPPORT |
| NAPLES HISTORICAL SOCIETY | NAPLES, FL | $10,000 | 2025 | OPERATING SUPPORT |
| GREENWICH SPANISH SCHOOL | GREENWICH, CT | $10,000 | 2025 | OPERATING SUPPORT |
| NAPLES HISTORICAL SOCIETY | NAPLES, FL | $10,000 | 2025 | OPERATING SUPPORT |
| KREMPELS CENTER | PORTSMOUTH, NH | $10,000 | 2025 | OPERATING SUPPORT |
| KREMPELS CENTER | PORTSMOUTH, NH | $10,000 | 2025 | OPERATING SUPPORT |
| HUMANE SOCIETY OF COLLIER COUNTY INC | NAPLES, FL | $6,000 | 2025 | OPERATING SUPPORT |
| HUMANE SOCIETY OF NAPLES | NAPLES, FL | $6,000 | 2025 | OPERATING SUPPORT |
| AMERICAN CANCER SOCIETY | ATLANTA, GA | $475,000 | 2024 | OPERATING SUPPORT |
| CURE ALZHEIMER'S FUND | WELLESLEY HILLS, MA | $350,000 | 2024 | OPERATING SUPPORT |
| ROTARY CLUB OF NAPLES CHARITABLE FOUNDATION | NAPLES, FL | $150,000 | 2024 | LEARN2EARN SCHOLARSHIP PROGRAM |
| ST MATTHEW'S HOUSE | NAPLES, FL | $130,000 | 2024 | OPERATING SUPPORT |
| NATIONAL ALLIANCE ON MENTAL ILLNESS | ARLINGTON, VA | $95,000 | 2024 | OPERATING SUPPORT |
| HOMES FOR OUR TROOPS | TAUNTON, MA | $85,000 | 2024 | OPERATING SUPPORT |
| ST JUDE CHILDREN'S RESEARCH HOSPITAL | MEMPHIS, TN | $55,000 | 2024 | OPERATING SUPPORT |
| GUADALUPE CENTER | IMMOKALEE, FL | $30,000 | 2024 | OPERATING SUPPORT |
| AMERICAN CANCER SOCIETY | ATLANTA, GA | $20,000 | 2024 | RESEARCH COUNCIL |
| ABILIS | GREENWICH, CT | $12,000 | 2024 | OPERATING SUPPORT |
| APIFERA FARM INC | BREMEN, ME | $12,000 | 2024 | OPERATING SUPPORT |
| KREMPELS CENTER | PORTSMOUTH, NH | $10,000 | 2024 | OPERATING SUPPORT |
| US UKRAINIAN ACTIVISTS INC | BRISTOW, VA | $10,000 | 2024 | OPERATING SUPPORT |
| HUMANE SOCIETY OF NAPLES | NAPLES, FL | $6,000 | 2024 | OPERATING SUPPORT |
AMERICAN CANCER SOCIETY
$500,000OPERATING SUPPORT
AMERICAN CANCER SOCIETY
$495,000OPERATING SUPPORT
LEARN2EARN CHARITABLE FOUNDATION
$175,000OPERATING SUPPORT
ROTARY CLUB OF NAPLES CHARITABLE FOUNDATION
$150,000LEARN2EARN SCHOLARSHIP PROGRAM
ST MATTHEW'S HOUSE
$140,000OPERATING SUPPORT
ST MATTHEW'S HOUSE
$130,000OPERATING SUPPORT
NATIONAL ALLIANCE ON MENTAL ILLNESS
$95,000OPERATING SUPPORT
NATIONAL ALLIANCE ON MENTAL ILLNESS
$95,000OPERATING SUPPORT
HOMES FOR OUR TROOPS
$85,000OPERATING SUPPORT
HOMES FOR OUR TROOPS
$85,000OPERATING SUPPORT
APIFERA FARM INC
$12,000OPERATING SUPPORT
APIFERA FARM INC
$12,000OPERATING SUPPORT
GREENWICH SPANISH SCHOOL
$10,000OPERATING SUPPORT
KREMPELS CENTER
$10,000OPERATING SUPPORT
KREMPELS CENTER
$10,000OPERATING SUPPORT
HUMANE SOCIETY OF COLLIER COUNTY INC
$6,000OPERATING SUPPORT
HUMANE SOCIETY OF NAPLES
$6,000OPERATING SUPPORT
AMERICAN CANCER SOCIETY
$475,000OPERATING SUPPORT
ROTARY CLUB OF NAPLES CHARITABLE FOUNDATION
$150,000LEARN2EARN SCHOLARSHIP PROGRAM
ST MATTHEW'S HOUSE
$130,000OPERATING SUPPORT
NATIONAL ALLIANCE ON MENTAL ILLNESS
$95,000OPERATING SUPPORT
HOMES FOR OUR TROOPS
$85,000OPERATING SUPPORT
AMERICAN CANCER SOCIETY
$20,000RESEARCH COUNCIL
APIFERA FARM INC
$12,000OPERATING SUPPORT
KREMPELS CENTER
$10,000OPERATING SUPPORT
HUMANE SOCIETY OF NAPLES
$6,000OPERATING SUPPORT