The McKnight Brain Research Foundation concentrates its giving on large-scale biomedical research funding, especially supporting neuroscience and aging-related research through major intermediaries. Rather than many small local grants, it channels substantial multi-year awards to national research funders and collaborative research efforts. Its support is programmatic—targeting research infrastructure and investigator funding—rather than direct service or community-based programs.
Highly concentrated: a very small number of large grants directed to national research organizations and intermediaries, with repeat funding to the same major grantees.
McKnight Brain Research Foundation directs most of its funding to aging-brain research through national intermediaries and university brain institutes, with a clear emphasis on cognitive aging, memory loss, and neuroscience. Its largest recent grant was $2,578,200 to the American Federation for Aging Research in New York, followed by repeated support for the Foundation for the NIH in North Bethesda for research funding. The pattern points to programmatic backing for research infrastructure rather than a broad portfolio of local service grants. The foundation also supports recurring scholarship and institute funding. The American Brain Foundation in Minneapolis received multiple awards for scholarship in cognitive aging and memory loss, while the Evelyn F. McKnight Brain Institute at the University of Alabama Birmingham appears repeatedly in the recent grants list. Smaller awards to the University of Miami, University of Florida, and University of Arizona show that the foundation funds both larger coordinating organizations and affiliated research sites. Its active programs reinforce that profile: early-career awards in cognitive aging and age-related memory loss, clinical translational research scholarships, pilot grants, and institute-based pilot funding across the McKnight Brain Institutes.
Aging-brain research is the core of the foundation’s giving. It awarded $1,158,343 to the Foundation for the NIH in North Bethesda for funding of research, and an additional $1,155,230 in 2024 and $1,000,000 in 2023 to the same intermediary for the same purpose. For investigator support, the foundation gave $330,000 to the American Brain Foundation in Minneapolis in 2023 for scholarship in cognitive aging and memory loss, with follow-on awards in 2024 and 2025 for the same scholarship track. Its institute support extends to university-based brain research centers. The University of Alabama Birmingham received $197,063 in 2025 for the Evelyn F. McKnight Brain Institute at UAB, while the University of Arizona received $96,711 in 2024 for the Evelyn F. McKnight Brain Institute at the University of Arizona. The foundation also funds research at the University of Miami and the University of Florida, both listed with research-focused grants in the recent grants data.
$3.1M
$37.4M
$3.1M
$5.2M
Most grants fall between $32K and $330K, with a median of $112K.
25th Percentile
$32K
Median
$112K
75th Percentile
$330K
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Notable grantees: Foundation for the NIH, American Federation for Aging Research
Typical grants are mid- to large-sized, with a p25 of $32,005, a median of $111,684, and a p75 of $330,000. The recent record shows both concentrated recurring relationships and one-off awards: Foundation for the NIH, the American Brain Foundation, and several university partners each appear in multiple years. McKnight Brain Research Foundation is a grantmaking foundation, not a program that makes program-related investments. It also funds individuals through scholarships, including its active cognitive-aging scholarship and innovator award programs. Several active programs accept unsolicited applications, including the Innovator Awards, the Clinical Translational Research Scholarship, and Pilot Grants.
All recent grants in the data went to U.S. recipients. New York, New York appears as the top city for recipient activity through the American Federation for Aging Research, and North Bethesda, Maryland appears repeatedly through the Foundation for the NIH. Florida recipients include Coral Gables and Gainesville, while Birmingham and Tucson also recur among university grantees. The foundation’s HQ is in Orlando, but 29% of grants go to recipients in Florida, so its giving is national while still maintaining a substantial Florida presence.
Its core areas are cognitive aging, age-related memory loss, neuroscience and brain research, and aging-related neurodegenerative disorders such as dementia and Alzheimer’s. The recent grants also show support for research infrastructure, university brain institutes, and scholarship support for early-career clinician scientists.
Yes. The foundation funds individuals through scholarship and award programs, including a Clinical Translational Research Scholarship in Cognitive Aging and Age-Related Memory Loss and Innovator Awards for advanced assistant professors and recently appointed associate professors.
It gives through a mix of large research grants, scholarships, and institute support. The typical grant size is $32,005 at the 25th percentile, $111,684 at the median, and $330,000 at the 75th percentile. Multiple recipients appear in more than one year, indicating recurring relationships.
Yes for some active programs. The Innovator Awards in Cognitive Aging and Memory Loss, the McKnight Clinical Translational Research Scholarship, and the McKnight Brain Research Foundation Pilot Grants all accept unsolicited applications. The pilot grants run through the four McKnight Brain Institutes do not.
The top state by grant count is New York, and 29% of grants go to recipients in Florida. The recipient base is entirely U.S.-based in the recent grants data.
2026
Source: IRS Form 990-PF, fiscal year 2026.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| American Federation for Aging Research | New York, NY | $1,543,700 | 2026 | Funding of research |
| Foundation for the NIH | North Bethesda, MD | $1,000,000 | 2026 | Funding of research |
| American Brain Foundation | Minneapolis, MN | $247,500 | 2026 | Funding scholarship in cognitive aging and memory loss |
| University of Miami | Coral Gables, FL | $172,588 | 2026 | Funding of research |
| University of Alabama Birmingham | Birmingham, AL | $94,270 | 2026 | Funding of the Evelyn F. McKnight Brain Institute at UAB |
| University of Arizona | Tucson, AZ | $57,098 | 2026 | Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona |
| American Federation for Aging Research | New York, NY | $2,578,200 | 2025 | Funding of research |
| Foundation for the NIH | North Bethesda, MD | $1,158,343 | 2025 | Funding of research |
| American Brain Foundation | Minneapolis, MN | $276,253 | 2025 | Funding scholarship in cognitive aging and memory loss |
| University of Alabama Birmingham | Birmingham, AL | $197,063 | 2025 | Funding of the Evelyn F. McKnight Brain Institute at UAB |
| University of Miami | Coral Gables, FL | $106,488 | 2025 | Funding of research |
| University of Florida Foundation | Gainesville, FL | $104,100 | 2025 | Funding of research |
| University of Florida | Gainesville, FL | $17,832 | 2025 | Funding of research |
| University of Arizona | Tucson, AZ | $5,594 | 2025 | Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona |
| Foundation for the NIH | North Bethesda, MD | $1,155,230 | 2024 | Funding of research |
| American Brain Foundation | Minneapolis, MN | $296,250 | 2024 | Funding scholarship in cognitive aging and memory loss |
| University of Alabama Birmingham | Birmingham, AL | $111,684 | 2024 | Funding of the Evelyn F. McKnight Brain Institute at UAB |
| University of Arizona | Tucson, AZ | $96,711 | 2024 | Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona |
| University of Florida | Gainesville, FL | $22,047 | 2024 | Funding of research |
| Foundation for the NIH | North Bethesda, MD | $1,000,000 | 2023 | Funding of research |
| American Federation for Aging Research | New York, NY | $534,500 | 2023 | Funding of research |
| American Brain Foundation | Minneapolis, MN | $330,000 | 2023 | Funding scholarship in cognitive aging and memory loss |
| University of Miami | Coral Gables, FL | $150,000 | 2023 | Funding of research |
| University of Florida | Gainesville, FL | $49,828 | 2023 | Funding of research |
| University of Alabama Birmingham | Birmingham, AL | $32,005 | 2023 | Funding of the Evelyn F. McKnight Brain Institute at UAB |
| University of Arizona - Evelyn F McKnight Brain Institute | Tucson, AZ | $1,232 | 2023 | Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona |
| Grand Canyon Conservancy | Grand Canyon, AZ | $250 | 2023 | Funding of research |
Foundation for the NIH
$1,000,000Funding of research
Funding scholarship in cognitive aging and memory loss
University of Alabama Birmingham
$94,270Funding of the Evelyn F. McKnight Brain Institute at UAB
University of Arizona
Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona
Funding scholarship in cognitive aging and memory loss
University of Alabama Birmingham
$197,063Funding of the Evelyn F. McKnight Brain Institute at UAB
University of Florida
$17,832Funding of research
University of Arizona
$5,594Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona
Funding scholarship in cognitive aging and memory loss
University of Alabama Birmingham
$111,684Funding of the Evelyn F. McKnight Brain Institute at UAB
University of Arizona
$96,711Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona
University of Florida
$22,047Funding of research
Funding scholarship in cognitive aging and memory loss
University of Florida
$49,828Funding of research
University of Alabama Birmingham
$32,005Funding of the Evelyn F. McKnight Brain Institute at UAB
University of Arizona - Evelyn F McKnight Brain Institute
$1,232Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona