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    3. Hereditary Disease Foundation
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    Hereditary Disease Foundation

    ActiveMedical Research
    NEW YORK, NYWebsite2129282121

    About Hereditary Disease Foundation

    To fund transformative research to find treatments, and ultimately a cure, for Huntington’s disease and related disorders.

    Focus Areas

    Huntington’s disease researchneurodegenerative disease researchgene therapyRNA therapeuticsDNA repairsomatic instabilitybiomarkersscientific collaboration

    Who They Fund

    scientists/researchersresearch institutions (universities, labs)scientific research teams

    Funding Style

    research/project grants

    About Hereditary Disease Foundation

    Hereditary Disease Foundation centers its grantmaking on Huntington’s disease research, with funding that reaches from early-stage preliminary data collection to major collaborative projects. In the recent grants list, its largest award went to Children’s Hospital of Philadelphia for $1,150,000 in 2024, and another seven-figure grant went to Massachusetts General Hospital for $1,105,262 that same year. The foundation also backed Washington University School of Medicine in St Louis with $1,104,000 in 2025, showing that it supports work at a substantial scale as well as across multiple institutions. The recent awards point to a research funder that mixes project grants with career development and recognition. It gives one-year Research Grants, two-year Postdoctoral Fellowships, and larger Transformative Research Awards, while also sponsoring annual prizes for scientific work in Huntington’s disease. Recipients include Stanford University, the University of California Irvine, Northwestern University, Columbia University, and the J. David Gladstone Institutes. That mix suggests a portfolio aimed at both the next experiment and the next stage of a researcher’s career.

    What Hereditary Disease Foundation Funds

    The foundation’s strongest throughline is Huntington’s disease research, but its grants show several scientific angles within that focus. At Massachusetts Institute of Technology, it gave $223,328 in 2024 and another $185,828 in 2023, indicating repeated support for work there. It also awarded $100,000 in 2025 to the Center for Genomic Medicine at Massachusetts General Hospital. Therapeutic development is another clear emphasis. The Regents of the University of California, San Diego received $100,000 in 2025, and The Regents of the University of California, Los Angeles received $100,000 in 2025 as well, both within the foundation’s scientific research portfolio. In California, Stanford University appears in the recent grants list with $205,656 in 2024 and $177,837 in 2023, alongside a later $175,672 award to The Board of Trustees of the Leland Stanford in 2025. The foundation also backs work at the intersection of biomarkers, mechanisms, and translational research through awards to hospitals, universities, and biomedical institutes.

    How Hereditary Disease Foundation Gives

    Hereditary Disease Foundation’s typical grant size falls in a mid-six-figure range, with p25 at $75,000, a median of $100,000, and p75 at $185,828. The recent grants list shows both larger project awards and standard $100,000 grants, with one-year Research Grants, two-year Postdoctoral Fellowships, and Transformative Research Awards among its program types. The foundation accepts unsolicited applications for several programs, including Research Grants and postdoctoral support, using a competitive research-funding model. Recent awards span 2023 through 2025, which points to recurring support rather than one-off giving.

    Financial Snapshot

    Annual Giving

    $1.4M

    Total Assets

    $23.1M

    Total Revenue

    $4.1M

    Total Expenses

    $4.3M

    Typical Grant Size

    Most grants fall between $75K and $186K, with a median of $100K.

    25th Percentile

    $75K

    Median

    $100K

    75th Percentile

    $186K

    Geographic Reach

    National10 states funded

    About 5% of grants go to recipients in CA.

    Funding intensity
    Low
    High
    Headquarters

    Leadership

    MEGHAN DONALDSON

    Accepts unsolicited proposals

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    Privacy PolicyTerms of ServiceYour privacy choicesEnvironmental footprintSystem Status
    EIN (Tax ID): 23-7376197Latest Form 990: 2026Total assets: $23.1M5 filings on recordFind their full 990 filing →
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    support for scientific research activities
    competitive research funding

    Topics

    scientific research (general)basic scientific researchapplied scientific research

    Where Hereditary Disease Foundation Makes Grants

    Hereditary Disease Foundation gives nationally, and its recent grants are concentrated in the United States. California appears most often in the recipient list, including institutions in Palo Alto, Irvine, San Diego, Los Angeles, Redwood City, and San Francisco. Other frequent recipient cities include Philadelphia, Boston, Cambridge, and Saint Louis. New York recipients appear as well, including Columbia University in New York, NY, but only 5% of grants went to recipients in the foundation’s HQ state.

    Frequently Asked Questions About Hereditary Disease Foundation

    What kinds of research does Hereditary Disease Foundation fund?

    Its grants support Huntington’s disease research, especially scientific research on disease mechanisms, gene-targeted therapies, antisense oligonucleotides and RNA-based approaches, biomarkers, translational research, and early-career investigator development. The active program list also includes Transformative Research Awards, Research Grants, and Postdoctoral Fellowships.

    Does Hereditary Disease Foundation accept unsolicited applications?

    Yes. Several active programs accept unsolicited applications, including the Huntington’s Disease Career Advancement Grant, the HDF Transformative Research Award, the HDF Postdoctoral Fellowship, Research Grants, and the HDF Research Grant process described through ProposalCentral.

    What is a typical grant size?

    The foundation’s typical grant size is $100,000, with a p25 of $75,000 and a p75 of $185,828. Program levels range from awards under $10,000 for career advancement support to Transformative Research Awards of $300,000 to $500,000.

    How does Hereditary Disease Foundation support early-career researchers?

    It has multiple early-career programs: two-year postdoctoral fellowships of up to $100,000 per year, a Huntington’s Disease Career Advancement Grant for senior postdocs transitioning to independent academic careers, and the Nancy S. Wexler Young Investigator Prize for early-career recognition.

    Where does Hereditary Disease Foundation give most often?

    Its grantmaking is national, with California as the top state by grant count. The recent grants list includes recipients in Palo Alto, Irvine, San Diego, Los Angeles, Redwood City, and San Francisco, while 5% of grants went to recipients in New York.

    Latest 990 Filing

    2026

    Source: IRS Form 990-PF, fiscal year 2026.

    Open Grant Opportunities

    Current and upcoming funding from Hereditary Disease Foundation that your nonprofit may be able to apply for.

    Open nowCloses in 4 days (Oct 1, 2026)Award: Up to $100K

    HDF Grants and Fellowships

    Huntington’s disease researchtherapeutics discoverybasic science+2 more

    Who can apply: Postdoctoral fellowships are for promising early career scientists, including postdoctoral fellows or up to 7 years past PhD completion, committed to Huntington’s disease research. Research grants are for more experienced researchers with a specific research plan. International researchers are eligible. Fellows require a mentor support letter; grant applicants may include up to 2 letters of support from a mentor or key collaborators. Applicants must have timely submitted prior progress reports for previous HDF awards.

    Deadline: LOI submission dates for 2027 applications: August 17, 2026 to October 1, 2026; invitation to submit full application November 19, 2026; application deadline January 6, 2027; funding decision late February 2027; start date March-April 2027.

    View & apply
    Open nowCloses in 4 days (Oct 1, 2026)Award: Up to $100K

    HDF Research Grant

    Huntington’s disease researchDisease mechanismsDisease-modifying therapeutics+1 more

    Who can apply: Applicants must present a specific research plan directly relevant to Huntington’s disease. International researchers are eligible. Applicants with overdue progress reports are not eligible until reports are submitted and approved. Priority is given to innovative and impactful HD research.

    Deadline: For the 2027 cycle, LOIs are due October 1, 2026 and invited full applications are due January 6, 2027.

    View & apply
    Opening soonCloses Feb 19, 2027Award: $300K – $500K

    HDF Transformative Research Award (TRA)

    Huntington’s disease researchDisease mechanismsNovel therapeutics+5 more

    Who can apply: The contact PI must have an academic appointment with institutional commitment to carry out the proposed work. Investigators from academic institutions, companies, national laboratories, nonprofit institutes, and multi-institutional teams may apply. International researchers are eligible. Projects must have direct relevance to Huntington’s disease, be exceptionally novel, and include feasible milestones and metrics. Only one application may be submitted by an individual as contact PI.

    Deadline: 2027 LOIs open January 15, 2027 and are due February 19, 2027; invitations for full proposals April 1, 2027; full proposals due May 14, 2027; award announcements summer 2027.

    View & apply

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    Deadlines and eligibility are summarized from public sources and may change — always confirm the details on the funder's official application page before applying.

    Recent Grants

    Most recent grants reported to the IRS.

    RecipientLocationAmountYearPurpose
    THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYREDWOOD CITY, CA$200,0002026SCIENTIFIC RESEARCH
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA LOS ANGELESLOS ANGELES, CA$200,0002026SCIENTIFIC RESEARCH
    MASSACHUSETTS GENERAL HOSPITAL (MASS GENERAL)SOMMERVILLE, MA$200,0002026SCIENTIFIC RESEARCH
    MASSACHUSETTS INSTITUTE OF TECHNOLOGY - MITCAMBRIDGE, MA$200,0002026SCIENTIFIC RESEARCH
    MASSACHUSETTS GENERAL HOSPITAL (MASS GENERAL)SOMMERVILLE, MA$100,0002026SCIENTIFIC RESEARCH
    WASHINGTON UNIVERSITYSEATTLE, WA$100,0002026SCIENTIFIC RESEARCH
    MASSACHUSETTS INSTITUTE OF TECHNOLOGY - MITCAMBRIDGE, MA$100,0002026SCIENTIFIC RESEARCH
    THE CORPORATION OF MERCER UNIVERSITYMACON, GA$100,0002026SCIENTIFIC RESEARCH
    CHAN ZUCKERBERG BIOHUB (SAN FRANCISCO)SAN FRANCISCO, CA$100,0002026SCIENTIFIC RESEARCH
    THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKNEW YORK, NY$50,0002026SCIENTIFIC RESEARCH
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA LOS ANGELESLOS ANGELES, CA$50,0002026SCIENTIFIC RESEARCH
    WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST LOUISSAINT LOUIS, MO$1,104,0002025SCIENTIFIC RESEARCH
    NORTHWESTERN UNIVERSITYEVANSTON, IL$200,0002025SCIENTIFIC RESEARCH
    THE BOARD OF TRUSTEES OF THE LELAND STANFREDWOOD CITY, CA$175,6722025SCIENTIFIC RESEARCH
    CENTER FOR GENOMIC MEDICINE MASSACHUSETTS GENERAL HOSPITALBOSTON, MA$100,0002025SCIENTIFIC RESEARCH
    THE REGENTS UN OF CALIFORNIA -LOSANGELESLOS ANGELES, CA$100,0002025SCIENTIFIC RESEARCH
    REGENTS OF THE UNIVERSITY OF CA IRVINEIRVINE, CA$100,0002025SCIENTIFIC RESEARCH
    CHILDREN'S HOSPITAL OF PHILADELPHIA THEPHILADELPHIA, PA$100,0002025SCIENTIFIC RESEARCH
    MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA$100,0002025SCIENTIFIC RESEARCH
    REGENTS OF THE UNIV OF CA - SAN DIEGOLA JOLLA, CA$100,0002025SCIENTIFIC RESEARCH
    MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA$30,0002025SCIENTIFIC RESEARCH
    CHILDREN'S HOSPITAL OF PHILADELPHIAPHILADELPHIA, PA$1,150,0002024SCIENTIFIC RESEARCH
    MASSACHUSETTS GENERAL HOSPITALSOMMERVILLE, MA$1,105,2622024SCIENTIFIC RESEARCH
    MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA$223,3282024SCIENTIFIC RESEARCH
    CHILDREN'S HOSPITAL OF PHILADELPHIAPHILADELPHIA, PA$214,3882024SCIENTIFIC RESEARCH
    STANFORD UNIVERSITYPALO ALTO, CA$205,6562024SCIENTIFIC RESEARCH
    MASSACHUSETTS GENERAL HOSPITALBOSTON, MA$203,6842024SCIENTIFIC RESEARCH
    UNIVERSITY OF CALIFORNIA IRVINEIRVINE, CA$200,5842024SCIENTIFIC RESEARCH
    TRUSTEES OF COLUMBIA UNIVERSITYNEW YORK, NY$150,0002024SCIENTIFIC RESEARCH
    UNIVERSITY OF FLORIDAGAINESVILLE, FL$150,0002024SCIENTIFIC RESEARCH
    UNIVERSITY OF CALIFORNIA - IRVINEIRVINE, CA$150,0002024SCIENTIFIC RESEARCH
    THOMAS JEFFERSON UNIVERSITYPHILADELPHIA, PA$135,3202024SCIENTIFIC RESEARCH
    WASHINGTON UNIVERSITYSAINT LOUIS, MO$78,2702024SCIENTIFIC RESEARCH
    UNIVERSITY OF TEXASGALVESTON, TX$75,0002024SCIENTIFIC RESEARCH
    UNIVERSITY OF TEXASGALVESTON, TX$75,0002024SCIENTIFIC RESEARCH
    BRIGHAM AND WOMENS HOSPITALSOMERVILLE, MA$75,0002024SCIENTIFIC RESEARCH
    J DAVID GLADSTONE INSTITUTESSAN FRANCISCO, CA$75,0002024SCIENTIFIC RESEARCH
    UNIVERSITY OF SOUTHERN CALIFORNIA USCLOS ANGELES, CA$75,0002024SCIENTIFIC RESEARCH
    UNIVERSITY OF WASHINGTONSEATTLE, WA$75,0002024SCIENTIFIC RESEARCH
    UNIVERSITY OF ALABAMA AT BIRMINGHAMBIRMINGHAM, AL$75,0002024SCIENTIFIC RESEARCH
    THE REGENTS - UCLALOS ANGELES, CA$75,0002024SCIENTIFIC RESEARCH
    MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA$63,2402024SCIENTIFIC RESEARCH
    TRUSTEES OF COLUMBIA UNIVERSITYNEW YORK, NY$50,0002024SCIENTIFIC RESEARCH
    MASSACHUSETTS INSTITUTE OF TECHNOLOGYCAMBRIDGE, MA$185,8282023SCIENTIFIC RESEARCH
    STANFORD UNIVERSITYSTANFORD, CA$177,8372023SCIENTIFIC RESEARCH
    THE BOARD OF TRUSTEES OF THE LELAND STANFORDREDWOOD CITY, CA$135,3202023SCIENTIFIC RESEARCH
    UNIVERSITY OF MASSACHUSETTS MED SCHOOL DEWORCESTER, MA$130,0642023SCIENTIFIC RESEARCH
    J DAVID GLADSTONE INSTITUTESSAN FRANCISCO, CA$100,0002023SCIENTIFIC RESEARCH

    THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

    $200,000
    REDWOOD CITY, CA2026

    SCIENTIFIC RESEARCH

    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA LOS ANGELES

    $200,000
    LOS ANGELES, CA2026

    SCIENTIFIC RESEARCH

    MASSACHUSETTS GENERAL HOSPITAL (MASS GENERAL)

    $200,000
    SOMMERVILLE, MA2026

    SCIENTIFIC RESEARCH

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY - MIT

    $200,000
    CAMBRIDGE, MA2026

    SCIENTIFIC RESEARCH

    MASSACHUSETTS GENERAL HOSPITAL (MASS GENERAL)

    $100,000
    SOMMERVILLE, MA2026

    SCIENTIFIC RESEARCH

    WASHINGTON UNIVERSITY

    $100,000
    SEATTLE, WA2026

    SCIENTIFIC RESEARCH

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY - MIT

    $100,000
    CAMBRIDGE, MA2026

    SCIENTIFIC RESEARCH

    THE CORPORATION OF MERCER UNIVERSITY

    $100,000
    MACON, GA2026

    SCIENTIFIC RESEARCH

    CHAN ZUCKERBERG BIOHUB (SAN FRANCISCO)

    $100,000
    SAN FRANCISCO, CA2026

    SCIENTIFIC RESEARCH

    THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

    $50,000
    NEW YORK, NY2026

    SCIENTIFIC RESEARCH

    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA LOS ANGELES

    $50,000
    LOS ANGELES, CA2026

    SCIENTIFIC RESEARCH

    WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST LOUIS

    $1,104,000
    SAINT LOUIS, MO2025

    SCIENTIFIC RESEARCH

    NORTHWESTERN UNIVERSITY

    $200,000
    EVANSTON, IL2025

    SCIENTIFIC RESEARCH

    THE BOARD OF TRUSTEES OF THE LELAND STANF

    $175,672
    REDWOOD CITY, CA2025

    SCIENTIFIC RESEARCH

    CENTER FOR GENOMIC MEDICINE MASSACHUSETTS GENERAL HOSPITAL

    $100,000
    BOSTON, MA2025

    SCIENTIFIC RESEARCH

    THE REGENTS UN OF CALIFORNIA -LOSANGELES

    $100,000
    LOS ANGELES, CA2025

    SCIENTIFIC RESEARCH

    REGENTS OF THE UNIVERSITY OF CA IRVINE

    $100,000
    IRVINE, CA2025

    SCIENTIFIC RESEARCH

    CHILDREN'S HOSPITAL OF PHILADELPHIA THE

    $100,000
    PHILADELPHIA, PA2025

    SCIENTIFIC RESEARCH

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    $100,000
    CAMBRIDGE, MA2025

    SCIENTIFIC RESEARCH

    REGENTS OF THE UNIV OF CA - SAN DIEGO

    $100,000
    LA JOLLA, CA2025

    SCIENTIFIC RESEARCH

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    $30,000
    CAMBRIDGE, MA2025

    SCIENTIFIC RESEARCH

    CHILDREN'S HOSPITAL OF PHILADELPHIA

    $1,150,000
    PHILADELPHIA, PA2024

    SCIENTIFIC RESEARCH

    MASSACHUSETTS GENERAL HOSPITAL

    $1,105,262
    SOMMERVILLE, MA2024

    SCIENTIFIC RESEARCH

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    $223,328
    CAMBRIDGE, MA2024

    SCIENTIFIC RESEARCH

    CHILDREN'S HOSPITAL OF PHILADELPHIA

    $214,388
    PHILADELPHIA, PA2024

    SCIENTIFIC RESEARCH

    STANFORD UNIVERSITY

    $205,656
    PALO ALTO, CA2024

    SCIENTIFIC RESEARCH

    MASSACHUSETTS GENERAL HOSPITAL

    $203,684
    BOSTON, MA2024

    SCIENTIFIC RESEARCH

    UNIVERSITY OF CALIFORNIA IRVINE

    $200,584
    IRVINE, CA2024

    SCIENTIFIC RESEARCH

    TRUSTEES OF COLUMBIA UNIVERSITY

    $150,000
    NEW YORK, NY2024

    SCIENTIFIC RESEARCH

    UNIVERSITY OF FLORIDA

    $150,000
    GAINESVILLE, FL2024

    SCIENTIFIC RESEARCH

    UNIVERSITY OF CALIFORNIA - IRVINE

    $150,000
    IRVINE, CA2024

    SCIENTIFIC RESEARCH

    THOMAS JEFFERSON UNIVERSITY

    $135,320
    PHILADELPHIA, PA2024

    SCIENTIFIC RESEARCH

    WASHINGTON UNIVERSITY

    $78,270
    SAINT LOUIS, MO2024

    SCIENTIFIC RESEARCH

    UNIVERSITY OF TEXAS

    $75,000
    GALVESTON, TX2024

    SCIENTIFIC RESEARCH

    UNIVERSITY OF TEXAS

    $75,000
    GALVESTON, TX2024

    SCIENTIFIC RESEARCH

    BRIGHAM AND WOMENS HOSPITAL

    $75,000
    SOMERVILLE, MA2024

    SCIENTIFIC RESEARCH

    J DAVID GLADSTONE INSTITUTES

    $75,000
    SAN FRANCISCO, CA2024

    SCIENTIFIC RESEARCH

    UNIVERSITY OF SOUTHERN CALIFORNIA USC

    $75,000
    LOS ANGELES, CA2024

    SCIENTIFIC RESEARCH

    UNIVERSITY OF WASHINGTON

    $75,000
    SEATTLE, WA2024

    SCIENTIFIC RESEARCH

    UNIVERSITY OF ALABAMA AT BIRMINGHAM

    $75,000
    BIRMINGHAM, AL2024

    SCIENTIFIC RESEARCH

    THE REGENTS - UCLA

    $75,000
    LOS ANGELES, CA2024

    SCIENTIFIC RESEARCH

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    $63,240
    CAMBRIDGE, MA2024

    SCIENTIFIC RESEARCH

    TRUSTEES OF COLUMBIA UNIVERSITY

    $50,000
    NEW YORK, NY2024

    SCIENTIFIC RESEARCH

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    $185,828
    CAMBRIDGE, MA2023

    SCIENTIFIC RESEARCH

    STANFORD UNIVERSITY

    $177,837
    STANFORD, CA2023

    SCIENTIFIC RESEARCH

    THE BOARD OF TRUSTEES OF THE LELAND STANFORD

    $135,320
    REDWOOD CITY, CA2023

    SCIENTIFIC RESEARCH

    UNIVERSITY OF MASSACHUSETTS MED SCHOOL DE

    $130,064
    WORCESTER, MA2023

    SCIENTIFIC RESEARCH

    J DAVID GLADSTONE INSTITUTES

    $100,000
    SAN FRANCISCO, CA2023

    SCIENTIFIC RESEARCH