To find effective treatments and ultimately a cure for Fragile X syndrome.
FRAXA Research Foundation Inc centers its grantmaking on Fragile X syndrome, with a clear emphasis on moving research toward treatments and a cure. Its recent awards show a consistent pattern of support for biomedical teams working on Fragile X therapeutics, preclinical validation, and clinical research, including repeated funding to Yale School of Medicine and UMass Medical in Worcester. The foundation’s grant portfolio is built around investigator-driven research rather than individual support, and its active programs show a structured pathway from early-stage validation to human studies. FRAXA also prioritizes curative therapy approaches, including gene therapy, gene repair, gene reactivation, protein replacement, mRNA therapeutics, and targeted ASO treatments. Recent grants include $100,000 awards to Yale School of Medicine and UMass Medical, alongside many $50,000 grants to university and hospital-based research teams. That mix suggests a funder that backs both larger project awards and a broader bench of investigators working on Fragile X biology, translational models, and therapy development.
In Fragile X clinical research, FRAXA Research Foundation Inc supports human-subject studies with grants such as $50,000 to Children’s Hospital of Philadelphia for research. The foundation also backs translational work at academic medical centers: it gave $100,000 to University of California at Irvine for research and $50,000 to Massachusetts General Hospital for research. Curative therapy development is another visible priority, reflected in awards such as $50,000 to Cold Spring Harbor Laboratory for research. Its funded projects also include teams working on preclinical and biomarker-oriented research, as seen in grants to University of Rochester, Seattle Children’s Research Institute, and Cincinnati Children’s Hospital, each at $50,000. Across these examples, the focus stays on Fragile X-specific therapeutic development rather than broad neuroscience.
The typical grant size is tightly clustered: p25, median, and p75 are all $50,000. That points to a standardized award level for much of the foundation’s portfolio, with occasional larger grants at $81,401, $90,000, or $100,000. Recent recipients appear across multiple years, including Yale School of Medicine, UMass Medical, University of California at Irvine, Carnegie Mellon University, Emory University, Mercer University, Seattle Children’s Research Institute, Tufts University School of Medicine, and University of Illinois at Urbana-Champaign. The foundation is not an individual-giving or program-related-investment funder; it makes institutional research grants. Its active programs accept unsolicited applications, including fellowship, clinical trial, drug validation, and curative therapy grants.
$748K
$5M
$2.3M
$1.4M
Most grants fall between $50K and $50K, with a median of $50K.
25th Percentile
$50K
Median
$50K
75th Percentile
$50K
Katherine N Clapp
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FRAXA Research Foundation Inc gives nationally, with 100% of grants going to recipients in the United States. Pennsylvania is the top state by grant count, and Massachusetts accounts for 19% of grants. Recent awards reached research teams in Philadelphia, Pittsburgh, Worcester, Boston, and Cambridge, as well as New Haven, Irvine, Seattle, Cincinnati, and Chicago. The pattern is U.S.-wide rather than concentrated in one metro area.
It funds Fragile X syndrome research with an emphasis on translational and therapeutic work. Active program areas include clinical trials, preclinical drug validation, curative therapies, gene reactivation, gene therapy, antisense oligonucleotides, mRNA therapeutics, biomarker development, and drug repurposing.
The distribution is very uniform: p25 is $50,000, median is $50,000, and p75 is $50,000. Recent grants also include larger awards of $81,401, $90,000, and $100,000.
Yes. The active fellowship, clinical trial, drug validation, curative therapy, and general research grant programs all note that they accept unsolicited applications.
The top state by grant count is Pennsylvania. Massachusetts receives 19% of grants, and the recipient footprint also includes cities such as Philadelphia, Pittsburgh, Worcester, Boston, and Cambridge.
Recent grants go to universities and medical research institutions, including Yale School of Medicine, UMass Medical, University of California at Irvine, Children’s Hospital of Philadelphia, and Cold Spring Harbor Laboratory. The foundation does not fund individuals.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Current and upcoming funding from Fraxa Research Foundation that your nonprofit may be able to apply for.
Who can apply: Strictly for clinical research with human subjects who have Fragile X. Grants may support PIs, postdocs, graduate students, technicians, supplies, and other project costs. Institutions must waive indirect costs; FRAXA does not pay indirect costs.
Deadline: Accepted and reviewed on a rolling basis; no application deadline.
Who can apply: All work must be directed specifically at Fragile X therapeutics. Research topics may include enhanced model systems or biomarkers as well as therapeutic development. Proposals must be discussed in advance with FRAXA's Chief Scientific Officer, Dr. Michael Tranfaglia. Indirect costs are not allowed.
Deadline: Applications may be submitted at any time.
Who can apply: Must be clinical research with human subjects who have Fragile X. Priority is given to clinical trials of potentially disease-modifying agents previously validated in Fragile X animal models, especially prior FRAXA-funded research. Other Fragile X clinical research may be considered.
Deadline: No application deadline; accepted on a revolving/rolling basis.
Who can apply: Investigational or repurposed compounds intended for Fragile X research and therapeutic development.
Deadline: No specific deadline indicated; contact FRAXA for submission details.
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Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| Yale School of Medicine | New Haven, CT | $100,000 | 2025 | Research |
| Umass medical | Worcester, MA | $100,000 | 2025 | Research |
| Massachusetts General Hospital | Boston, MA | $50,000 | 2025 | Research |
| University of Rochester | Rochester, NY | $50,000 | 2025 | Research |
| Cold Spring Harbor Laboratory | Cold Spring Harbor, NY | $50,000 | 2025 | Research |
| University of California at Irvine | Irvine, CA | $50,000 | 2025 | Research |
| University of Wisconsin-Madison | Milwaukee, WI | $50,000 | 2025 | Research |
| Massachusetts Institute of Technology | Cambridge, MA | $50,000 | 2025 | Research |
| Cincinnati Children's Hospital | Cincinnati, OH | $50,000 | 2025 | Research |
| Children's Hospital of Philadelphia | Philadelphia, PA | $50,000 | 2025 | Research |
| Seattle Children's Research Institute | Seattle, WA | $50,000 | 2025 | Research |
| University of Illinois at Urbana-Champaign | Chicago, IL | $50,000 | 2025 | Research |
| National Institutes of health | Bethesda, MD | $48,200 | 2025 | Research |
| Umass medical | Worcester, MA | $100,000 | 2024 | Research |
| Yale School of Medicine | New Haven, CT | $100,000 | 2024 | Research |
| University of California at Irvine | Irvine, CA | $100,000 | 2024 | Research |
| University of Illinois at Urbana-Champaign | Chicago, IL | $50,000 | 2024 | Research |
| Seattle Children's Research Institute | Seattle, WA | $50,000 | 2024 | Research |
| Cold Spring Harbor Laboratory | Cold Spring Harbor, NY | $50,000 | 2024 | Research |
| Emory University | Atlanta, GA | $50,000 | 2024 | Research |
| University of Nebraska Medical Center | Omaha, NE | $50,000 | 2024 | Research |
| Tufts University School of Medicine | Boston, MA | $50,000 | 2024 | Research |
| University of Californiam Riverside | Riverside, CA | $50,000 | 2024 | Research |
| Icahn School of Medicine at Mount Sinai | New York, NY | $50,000 | 2024 | Research |
| Mercer University | Macon, GA | $50,000 | 2024 | Research |
| Carnegie Mellon University | Pittsburgh, PA | $50,000 | 2024 | Research |
| University of Californiam Riverside | Riverside, CA | $95,000 | 2023 | Research |
| University fo Wisconsin-Madison | Milwaukee, WI | $90,000 | 2023 | Research |
| Umass medical | Worcester, MA | $81,401 | 2023 | Research |
| Rush University Medical Center | Chicago, IL | $65,324 | 2023 | Research |
| Carnegie Mellon University | Pittsburgh, PA | $53,000 | 2023 | Research |
| Icahn School of Medicine | New York, NY | $50,000 | 2023 | Research |
| Emory University | Atlanta, GA | $50,000 | 2023 | Research |
| Tufts University School of Medicine | Boston, MA | $50,000 | 2023 | Research |
| Mercer University | Macon, GA | $50,000 | 2023 | Research |
| Massachusetts General Hospital | Somerville, MA | $50,000 | 2023 | Research |
| University of California at Irvine | Irvine, CA | $50,000 | 2023 | Research |
| University of Nebraska Medical Center | Omaha, NE | $50,000 | 2023 | Research |
| Salk Institue for Biological Studies | La Jolla, CA | $45,000 | 2023 | Research |
| University of Rochester | Rochester, NY | $45,000 | 2023 | Research |
| Standford University School of Medicine | Redwood City, CA | $45,000 | 2023 | Research |
| Wake Forest School of Medicine | Winston Salem, NC | $45,000 | 2023 | Research |
Umass medical
$100,000Research
Massachusetts General Hospital
$50,000Research
University of Rochester
$50,000Research
University of California at Irvine
$50,000Research
University of Wisconsin-Madison
$50,000Research
University of Illinois at Urbana-Champaign
$50,000Research
National Institutes of health
$48,200Research
University of California at Irvine
$100,000Research
University of Illinois at Urbana-Champaign
$50,000Research
University of Nebraska Medical Center
$50,000Research
University of Californiam Riverside
$50,000Research
University of Californiam Riverside
$95,000Research
University fo Wisconsin-Madison
$90,000Research
Emory University
$50,000Research
Massachusetts General Hospital
$50,000Research
University of California at Irvine
$50,000Research
University of Nebraska Medical Center
$50,000Research
Salk Institue for Biological Studies
$45,000Research
University of Rochester
$45,000Research
