City of Hope is a leading cancer research and treatment organization dedicated to bringing laboratory breakthroughs to patients quickly, providing personalized, innovative treatments and compassionate care to conquer cancer, diabetes, HIV/AIDS and other life-threatening diseases.
City of Hope National Medical Center centers its grantmaking on community benefit work tied to health, with recent awards spanning operating support, health equity, healthy living, food access, and medical education. The largest recent grants are three $8,000,000 operating support awards to City of Hope Medical Foundation in 2023, 2024, and 2025, showing a repeated institutional commitment at a very large scale. Beyond those major awards, the foundation also funded The Translational Genomics Research Institute with $611,088 in 2025 for operating support, alongside other health-related recipients in Southern California and Arizona. The foundation’s public community-benefit programs add another layer to that picture. FY2024 initiatives include Healthy Living, Health Equity, Community Capacity Building, and the Food for All Initiative in the Greater San Gabriel Valley Hospital Collaborative. It also lists small community grants through City of Hope Kindness Grants, plus food-access programs such as Produce for Patients, Garden of Hope, and Kids Run Farmers Markets. Across these efforts, the pattern is less about one narrow program and more about direct support for health-focused partners, local community organizations, and services that connect clinical work to nearby communities.
Health equity and community health are central themes in the foundation’s giving. In 2024, it awarded $10,000 to Rainbow Labs Mentoring Inc for a Healthy Living Grant and another $10,000 to Montclair Community Foundation for a Healthy Living Grant, both tied to community education and healthy living. Food access is another recurring area. Eco Urban Gardens received $45,000 in 2023 as a Community Benefit Grant, while Growing Hope Gardens received $8,420 in 2024 through Healthy Living and Kindness Grants. The FY2024 Community Benefit Report also names the Food for All Initiative in the Greater San Gabriel Valley Hospital Collaborative, plus Produce for Patients, Garden of Hope, and Kids Run Farmers Markets. Capacity building appears through local nonprofit support as well. Inland Valley Hope Partners received $10,000 in 2024 as a Community Building Grant, and Antelope Valley Partners for Health received $10,400 for the same category.
$8.6M
$4.8B
$2.9B
$2.8B
Most grants fall between $10K and $565K, with a median of $22K.
25th Percentile
$10K
Median
$22K
75th Percentile
$565K
Robert W Stone
COH President & CEO
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Typical grants cluster at the lower end, with a p25 of $10,000 and a median of $22,250, but the upper quartile rises sharply to $565,434, reflecting a mix of small community awards and much larger operating support. The recent record also shows repeated support over multiple years, especially the annual $8,000,000 operating support grants to City of Hope Medical Foundation in 2023, 2024, and 2025. The foundation makes program-related investments and funds individuals is false. Several program entries also accept unsolicited requests, including Healthy Living, Health Equity, Kindness Grants, and Food for All.
Giving is regional and heavily concentrated in California: 75% of grants go to recipients in the HQ state. Arizona is the top state by grant count, with The Translational Genomics Research Institute in Phoenix receiving a 2025 operating support grant and California Health Foundation and Trust also listed in Phoenix. Recipient cities in California include Duarte, Los Angeles, City of Industry, Lancaster, and Montclair. Every recent grant listed is in the United States.
The foundation’s stated focus areas include cancer research, cellular immunotherapy (CAR T), clinical trials, medical treatment for cancer, diabetes research and care, HIV/AIDS research and care, and medical education and training. Its community-benefit programs also emphasize healthy living, health equity, capacity building, and food access.
The grant-size profile is centered on smaller awards, with a p25 of $10,000 and a median of $22,250. The upper quartile is much higher at $565,434, showing that the foundation also makes large operating support grants alongside smaller community grants.
Yes. The recent grants show City of Hope Medical Foundation receiving $8,000,000 in 2023, 2024, and 2025 for operating support. The Translational Genomics Research Institute also appears more than once, with $500,000 in 2023 and $611,088 in 2025.
Several community-benefit programs accept unsolicited requests, including Healthy Living, Health Equity, City of Hope Kindness Grants, and the Food for All Initiative. These programs are tied to community education, food insecurity, capacity building, and health equity in communities served by City of Hope.
Its giving is regional, with 75% of grants going to recipients in California. Arizona has the highest grant count by state, and recent California recipients include Duarte, Los Angeles, City of Industry, Lancaster, and Montclair.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| City of Hope Medical Foundation | DUARTE, CA | $8,000,000 | 2025 | OPERATING SUPPORT |
| The Translational Genomics Research Institute | PHOENIX, AZ | $611,088 | 2025 | OPERATING SUPPORT |
| City of Hope Medical Foundation | — | $8,000,000 | 2024 | Operating Support. |
| California Health Foundation and Trust | — | $53,951 | 2024 | See Part IV |
| Lyte Foundation Inc | — | $25,000 | 2024 | Healthy Living Grant |
| Foothill Unity Center Inc | — | $19,500 | 2024 | Americorps sponsorship |
| Antelope Valley Partners for Health | — | $10,400 | 2024 | Community Building Grant |
| Rainbow Labs Mentoring Inc | — | $10,000 | 2024 | Healthy Living Grant |
| Inland Valley Hope Partners | — | $10,000 | 2024 | Community Building Grant |
| Montclair Community Foundation | — | $10,000 | 2024 | Healthy Living Grant |
| Public Health Foundation Enterprises Inc | — | $10,000 | 2024 | Community Benefit Grant; Health Consortium of the San Gabriel Valley |
| Growing Hope Gardens | — | $8,420 | 2024 | Healthy Living and Kindness Grants |
| City of Hope Medical Foundation | Sacramento, CA | $8,000,000 | 2023 | Operating Support |
| California Health Foundation and Trust | Phoenix, AZ | $587,246 | 2023 | See Part IV |
| The Translational Genomics Research Institute | Duarte, CA | $500,000 | 2023 | Operating Support |
| ECO URBAN GARDENS | Los Angeles, CA | $45,000 | 2023 | Community Benefit Grant |
| Public Health Foundation Enterprises Inc | City of Industry, CA | $15,000 | 2023 | Community Benefit Grant |
| ANTELOPE VALLEY PARTNERS FOR HEALTH | Lancaster, CA | $10,000 | 2023 | Healthy Living Grant |
Lyte Foundation Inc
$25,000Healthy Living Grant
Americorps sponsorship
Inland Valley Hope Partners
$10,000Community Building Grant
Montclair Community Foundation
$10,000Healthy Living Grant
Community Benefit Grant; Health Consortium of the San Gabriel Valley
Growing Hope Gardens
$8,420Healthy Living and Kindness Grants
ECO URBAN GARDENS
$45,000Community Benefit Grant