
To enable and advance research and commercial use of the International Space Station National Laboratory by connecting researchers, industry, and educators with low‑earth orbit capabilities to accelerate science, technology development, in‑space production, and STEM education.
Center for the Advancement of Science in Space Inc. is built around funding research and commercial use of the International Space Station National Laboratory, with grants that support flight projects, mission integration, and education tied to low-Earth orbit. Its recent awards show a strong applied-research profile: Space Tango Inc. received $1,145,781 in 2024 for implementation support across multiple flight projects, and the Regents of the University of Colorado received $972,528 in 2025 for the same type of role. The foundation also backs specialized science that uses the ISS environment directly, including a $423,958 grant to Stanford University for wide bandgap semiconductor materials and a $257,416 grant to Oculogenex Inc for gene therapy research aimed at preventing spaceflight-associated oxidative stress and apoptosis. Other awards support microgravity work in biomedical research, advanced materials, and in-space production. The organization’s grantmaking is tied to implementation partnerships as well as project-based science, so its portfolio combines technical operators with universities and research institutions. Within the recent grants list, several recipients appear more than once across multiple years, which points to continuing relationships rather than isolated awards.
The strongest theme in the portfolio is space-enabled applied science. Stanford University received $423,958 in 2025 to produce wide bandgap semiconductor materials with reduced defects for aviation, automotive, and communication uses. In biomedical research, Oculogenex Inc was awarded $257,416 in 2025 for gene therapy to prevent spaceflight-associated oxidative stress and apoptosis, while Cedars-Sinai Medical Center received $225,000 in 2025 to improve the production and vascularization of cardiac spheroids derived from human induced pluripotent stem cells. The foundation also funds materials research with industrial relevance: Palo Alto Research Center Parc received $199,813 in 2025 for microgravity synthesis of aerogel copolymers. Education and workforce development are another visible thread, reflected in program areas tied to STEM education, workforce development, and fellowship support.
$5M
$5.2M
$17.3M
$17.8M
Most grants fall between $22K and $86K, with a median of $50K.
25th Percentile
$22K
Median
$50K
75th Percentile
$86K
About 4% of grants go to recipients in CA.
RAMON RAY LUGO III
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Typical grant size clusters around a median of $50,000, with a lower quartile of $22,283 and an upper quartile of $85,987. The recent grants list includes both very large implementation awards and smaller project grants, suggesting mixed-use funding across research, operations, and education. Multiple recipients recur across years, including Space Tango Inc, Regents of the University of Colorado, Redwire Space Technologies Inc, Techshot Inc, Nanoracks LLC, and Oculogenex Inc. The foundation is a nonprofit operating through the ISS National Laboratory framework rather than an individual donor vehicle. Some opportunities accept unsolicited proposals, while others are targeted or program-specific.
Grantmaking is national, and every recipient in the recent grants list is in the United States. The most frequent recipient locations include Greenville, Indiana; Houston, Texas; Denver, Colorado; and Lexington, Kentucky. Other repeated locations include La Habra, California, Atlanta, Georgia, and Birmingham, Alabama. Florida is the top state by grant count, accounting for 5% of grants to recipients in the state, even though the headquarters are in Rockledge, Florida.
It funds ISS National Lab-related research, in-space production, technology development, and STEM education. Recent awards include implementation support for multiple flight projects, semiconductor materials research, gene therapy work related to spaceflight oxidative stress, and cardiac spheroid research.
The grant-size distribution centers on a median of $50,000, with the 25th percentile at $22,283 and the 75th percentile at $85,987. The recent grants list also includes awards well above that range for implementation and flight-project support.
The recent grants list is entirely U.S.-based: 116 grants, or 100.0%, went to recipients in the United States. The active opportunity descriptions also include both U.S. and international geography in some program areas.
Yes. Several organizations appear in multiple years, including Space Tango Inc, Regents of the University of Colorado, Redwire Space Technologies Inc, Techshot Inc, Nanoracks LLC, and Oculogenex Inc. That pattern suggests ongoing project relationships rather than one-time awards only.
Among the active programs listed, Current and Upcoming Opportunities accepts unsolicited proposals. The other named pathways shown are marked as not accepting unsolicited applications.
2026
Source: IRS Form 990-PF, fiscal year 2026.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| Eascra Biotech | Boston, MA | $432,300 | 2026 | Life Science Grant |
| Nanoracks LLC | Webster, TX | $365,828 | 2026 | Flight Projects |
| Space Tango Inc | Lexington, KY | $365,240 | 2026 | Flight Projects |
| TransAstra Corporation | Los Angeles, CA | $290,625 | 2026 | Education Grant |
| Redwire Space Technologies Inc | Greenville, IN | $280,387 | 2026 | Flight Projects |
| Leocloud Inc | Ashburn, VA | $255,060 | 2026 | Physical Science Grant |
| Regents of the University of Colorado | Denver, CO | $254,779 | 2026 | Flight Projects |
| Axiom Space | Houston, TX | $248,596 | 2026 | Flight Projects |
| Alpha Space Test and Research Alliance LLC | Houston, TX | $246,743 | 2026 | Physical Science Grant |
| Regents of the University of Colorado | Denver, CO | $201,488 | 2026 | Life Science Grant |
| Xheme Inc | Newton Center, MA | $199,137 | 2026 | Physical Science Grant |
| Tec-Masters Inc | Huntsville, AL | $154,155 | 2026 | Flight Projects |
| Cedars-Sinai Medical Center | Los Angeles, CA | $150,000 | 2026 | Life Science Grant |
| Redpoint Oncology Inc | Holden, MA | $137,860 | 2026 | Life Science Grant |
| Wake Forest University Health Sciences | Charlotte, NC | $131,237 | 2026 | Life Science Grant |
| The Regents of the University of California San Diego | Los Angeles, CA | $120,000 | 2026 | Education Grant |
| Rendezvous Robotics Inc | Cambridge, MA | $96,750 | 2026 | Physical Science Grant |
| VRCORE Inc | Fort Worth, TX | $95,000 | 2026 | Education Grant |
| Teledyne Brown Engineering Inc | Pittsburgh, PA | $90,000 | 2026 | Flight Projects |
| Palo Alto Research Center Parc | Palo Alto, CA | $74,930 | 2026 | Physical Science Grant |
| Stanford University | Stanford, CA | $69,350 | 2026 | Physical Science Grant |
| Orion's Quest | Plymouth, MI | $62,500 | 2026 | Education Grant |
| Sciperio Inc | Orlando, FL | $60,000 | 2026 | Life Science Grant |
| Embrace Space LLC | Houston, TX | $60,000 | 2026 | Education Grant |
| Carthage College | Kenosha, WI | $52,520 | 2026 | Education Grant |
| Fourier LLC | West Newton, MA | $50,000 | 2026 | Physical Science Grant |
| Cornerstone Research Group Inc | Miamisburg, OH | $45,000 | 2026 | Physical Science Grant |
| RevBio Inc | Lowell, MA | $42,770 | 2026 | Life Science Grant |
| Cleveland Clinic | Cleveland, OH | $40,000 | 2026 | Education Grant |
| Oculogenex Inc | La Habra, CA | $35,991 | 2026 | Physical Science Grant |
| Quest Institute for Quality Education | San Jose, CA | $35,000 | 2026 | Education Grant |
| Myriad Sensors Inc dba PockletLab | Franklin, TN | $31,000 | 2026 | Education Grant |
| Science Friday Initiative Inc | New York, NY | $29,440 | 2026 | Education Grant |
| Creatorspace | League City, TX | $20,000 | 2026 | Education Grant |
| Cornell University | Ithaca, NY | $17,400 | 2026 | Education Grant |
| University of Texas MD Anderson | Houston, TX | $17,366 | 2026 | Life Science Grant |
| Leidos Inc | Reston, VA | $16,515 | 2026 | Physical Science Grant |
| Johns Hopkins University | Baltimore, MD | $16,165 | 2026 | Life Science Grant |
| Emory University | Atlanta, GA | $16,050 | 2026 | Life Science Grant |
| Flawless Photonics Inc | Mountain View, CA | $15,804 | 2026 | Physical Science Grant |
| The Methodist Hospital Research Institute | Houston, TX | $15,362 | 2026 | Physical Science Grant |
| Lambda Vision | Farmington, CT | $15,000 | 2026 | Flight Projects |
| Amplyus LLC | Cambridge, MA | $13,500 | 2026 | Education Grant |
| Rhodium Scientific LLC | Houston, TX | $13,500 | 2026 | Education Grant |
| University of Alabama at Birmingham | Birmingham, AL | $13,050 | 2026 | Life Science Grant |
| The University of Alabama | Tuscaloosa, AL | $12,858 | 2026 | Education Grant |
| Institute Of Competition Sciences | San Francisco, CA | $12,425 | 2026 | Education Grant |
| Arizona State University | Tempe, AZ | $7,396 | 2026 | Education Grant |
| Association of Space Explorers | Webster, TX | $5,432 | 2026 | Education Grant |
| REGENTS OF THE UNIVERSITY OF COLORADO | DENVER, CO | $972,528 | 2025 | IMPLEMENTATION PARTNER FOR MULTIPLE FLIGHT PROJECTS |
Eascra Biotech
$432,300Life Science Grant
Nanoracks LLC
$365,828Flight Projects
Space Tango Inc
$365,240Flight Projects
TransAstra Corporation
$290,625Education Grant
Redwire Space Technologies Inc
$280,387Flight Projects
Leocloud Inc
$255,060Physical Science Grant
Regents of the University of Colorado
Flight Projects
Axiom Space
$248,596Flight Projects
Alpha Space Test and Research Alliance LLC
$246,743Physical Science Grant
Regents of the University of Colorado
$201,488Life Science Grant
Xheme Inc
$199,137Physical Science Grant
Tec-Masters Inc
$154,155Flight Projects
Redpoint Oncology Inc
$137,860Life Science Grant
The Regents of the University of California San Diego
$120,000Education Grant
Rendezvous Robotics Inc
$96,750Physical Science Grant
VRCORE Inc
$95,000Education Grant
Teledyne Brown Engineering Inc
$90,000Flight Projects
Palo Alto Research Center Parc
$74,930Physical Science Grant
Orion's Quest
$62,500Education Grant
Sciperio Inc
$60,000Life Science Grant
Embrace Space LLC
$60,000Education Grant
Carthage College
$52,520Education Grant
Fourier LLC
$50,000Physical Science Grant
Cornerstone Research Group Inc
$45,000Physical Science Grant
RevBio Inc
$42,770Life Science Grant
Oculogenex Inc
$35,991Physical Science Grant
Quest Institute for Quality Education
$35,000Education Grant
Myriad Sensors Inc dba PockletLab
$31,000Education Grant
Creatorspace
$20,000Education Grant
University of Texas MD Anderson
$17,366Life Science Grant
Leidos Inc
$16,515Physical Science Grant
Flawless Photonics Inc
$15,804Physical Science Grant
The Methodist Hospital Research Institute
$15,362Physical Science Grant
Lambda Vision
$15,000Flight Projects
Amplyus LLC
$13,500Education Grant
Rhodium Scientific LLC
$13,500Education Grant
University of Alabama at Birmingham
$13,050Life Science Grant
The University of Alabama
$12,858Education Grant
Institute Of Competition Sciences
$12,425Education Grant
Arizona State University
$7,396Education Grant
Association of Space Explorers
$5,432Education Grant
REGENTS OF THE UNIVERSITY OF COLORADO
$972,528IMPLEMENTATION PARTNER FOR MULTIPLE FLIGHT PROJECTS