The C D Spangler Foundation focuses its large, strategic philanthropy on health — particularly multiple sclerosis research and treatment — and on strengthening cultural and educational institutions in the Charlotte area. Its grants are often multi‑million dollar gifts that support capital campaigns, endowments, and major program initiatives at hospitals, university research centers, private schools, and performing arts organizations. The foundation mixes local civic investments (Charlotte Symphony, Discovery Place, Darlington School) with national health investments (National MS Society, UCSF).
C D Spangler Foundation Inc has made multiple $5 million grants in back-to-back years to the National Multiple Sclerosis Society and UCSF, making multiple sclerosis research and treatment one of the clearest threads in its recent giving. That health focus sits alongside major commitments to Charlotte institutions and selected education organizations. The foundation gave $10 million to Atrium Health Foundation in 2023, then followed with other large health and human services grants, including $1 million to Mayo Clinic and $625,000 to Care Ring. Its Charlotte-area support also includes $2.6 million to Charlotte Symphony Orchestra, $2.5 million to Discovery Place - Nature Museum Capital Campaign, and $1 million to Treescharlotte Foundation - Endowment Fund. Outside health and culture, the foundation has backed schools and universities with substantial gifts such as $2.15 million to Darlington School, $750,000 to NC School of Science & Mathematics Foundation, and repeated seven-figure support for Harvard Business School. The pattern is one of large, designated grants to institutions rather than small dispersed awards.
Health is a central theme. In 2023, C D Spangler Foundation Inc gave $10 million to Atrium Health Foundation to assist in health and human services, and in 2024 it gave $1 million to Mayo Clinic for the same broad purpose. Multiple sclerosis is a separate, sustained line of support: the foundation awarded $5 million to the National Multiple Sclerosis Society in 2024 and another $5 million in 2025, plus $5 million to UCSF Foundation in 2024 and $5 million to UCSF - Multiple Sclerosis in 2025. Education appears through institutional support as well. The foundation gave $2.15 million to Darlington School in 2024 and $750,000 to NC School of Science & Mathematics Foundation in 2025. Cultural and community institutions also receive major program support, including Charlotte Symphony Orchestra and Discovery Place - Nature Museum Capital Campaign.
Typical grants cluster around a $25,000 median, with a first quartile of $10,000 and a third quartile of $100,000, even though the foundation also makes occasional multi-million-dollar awards. The recent record shows repeated gifts to the same institutions across multiple years, including the National Multiple Sclerosis Society, UCSF, Harvard Business School, and Darlington School. That indicates a recurring, relationship-based pattern rather than one-off support. The foundation is a private foundation, does not fund individuals, and does not make program-related investments. No application process is stated in the provided data.
$24.3M
$637.6M
$112.3M
$25.4M
Most grants fall between $10K and $100K, with a median of $25K.
25th Percentile
$10K
Median
$25K
75th Percentile
$100K
About 54% of grants go to recipients in NC.
Top 2 recipient countries by grant volume for C D Spangler Foundation.
| Rank | Country | Grants | Total | Share |
|---|---|---|---|---|
| 1 | United StatesDomestic | 361 | $74.6M | 99.7% |
| 2 | Canada |
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Concentrated, high-dollar giving to a small set of priority institutions: few but very large grants, frequently for capital campaigns, endowments, and research funding; mix of repeat national health grantees and targeted local civic beneficiaries.
Notable grantees: National Multiple Sclerosis Society, Atrium Health Foundation, UCSF (Multiple Sclerosis research), Charlotte Symphony Orchestra, Darlington School
Most grants go to North Carolina recipients, which account for 54% of grants. Charlotte appears frequently, with awards to Atrium Health Foundation, Charlotte Symphony Orchestra, Discovery Place - Nature Museum Capital Campaign, Treescharlotte Foundation, and Care Ring. Other North Carolina recipients include Durham and New York is not a giving state here despite appearances in a grantee address. Outside the state, the foundation has supported organizations in Washington, DC; San Francisco, CA; Rome, GA; Boston, MA; Rochester, MN; Stanford, CA; Wellesley, MA; and Cambridge, MA. The country distribution is overwhelmingly U.S.-based, with one grant in Canada.
The foundation gives large institutional grants in health, education, and civic culture. Recent examples include health and human services support, multiple sclerosis research and treatment, school and university gifts, and funding for Charlotte arts and museum institutions.
Yes. The recent grants list shows repeated support to several organizations across multiple years, including the National Multiple Sclerosis Society in 2024 and 2025, UCSF in 2024 and 2025, Harvard Business School in 2023 and 2025, and Darlington School in 2023 and 2025.
The grant-size distribution centers on a $25,000 median. The lower quartile is $10,000 and the upper quartile is $100,000, while the recent grants list also includes awards in the millions.
North Carolina is the top state by grant count, with 54% of grants going to recipients in the state. Charlotte is the most visible city in the recent grants, with support for Atrium Health Foundation, Charlotte Symphony Orchestra, Discovery Place, Treescharlotte Foundation, and Care Ring.
No. The foundation’s profile indicates that it does not fund individuals.
2025
Source: IRS Form 990-PF, fiscal year 2025.
| 1 |
| $25K |
0.3% |
Recipient country reflects the grantee's headquarters per IRS 990-PF and Schedule F filings, not the program's implementation country.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| UCSF - MULTIPLE SCLEROSIS | SAN FRANCISCO, CA | $5,000,000 | 2025 | TO ASSIST IN HEALTH AND HUMAN SERVICES |
| NATIONAL MULTIPLE SCLEROSIS SOCIETY | WASHINGTON, DC | $5,000,000 | 2025 | TO ASSIST IN HEALTH AND HUMAN SERVICES |
| FFTC - CHARLOTTE SYMPHONY ORCHESTRA ENDOWMENT CAMPAIGN | CHARLOTTE, NC | $2,500,000 | 2025 | PROGRAM SUPPORT |
| DARLINGTON SCHOOL - CAPITAL CAMPAIGN | ROME, GA | $1,000,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| HARVARD BUSINESS SCHOOL | BOSTON, MA | $1,000,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| NC SCHOOL OF SCIENCE & MATHEMATICS FOUNDATION | DURHAM, NC | $750,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| SAFE ALLIANCE - THE UMBRELLA CENTER CAPITAL CAMPAIGN | CHARLOTTE, NC | $500,000 | 2025 | PROGRAM SUPPORT |
| FIDELITY CHARITABLE | NEW YORK, NY | $330,000 | 2025 | PROGRAM SUPPORT |
| TRINITY EPISCOPAL SCHOOL - CAPITAL CAMPAIGN | CHARLOTTE, NC | $300,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| WELLESLEY COLLEGE | WELLESLEY, MA | $300,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| SAMARITAN'S PURSE | BOONE, NC | $250,000 | 2025 | PROGRAM SUPPORT |
| FFTC - READ CHARLOTTE | CHARLOTTE, NC | $250,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| MAYO CLINIC | ROCHESTER, MN | $250,000 | 2025 | TO ASSIST IN HEALTH AND HUMAN SERVICES |
| THE FOUNDATION FOR NC A&T STATE UNIVERSITY | GREENSBORO, NC | $250,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| UNITED WAY OF GREATER CHARLOTTE | CHARLOTTE, NC | $250,000 | 2025 | PROGRAM SUPPORT |
| CMS FOUNDATION - MUSICAL INSTRUMENTS PROGRAM | CHARLOTTE, NC | $250,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| TEACH FOR AMERICA | CHARLOTTE, NC | $250,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| COMMUNITY FOUNDATION OF WESTERN CAROLINA | ASHEVILLE, NC | $250,000 | 2025 | PROGRAM SUPPORT |
| CAROLINA FARM TRUST | CORNELIUS, NC | $250,000 | 2025 | PROGRAM SUPPORT |
| HARVARD UNIVERSITY FBO HARVARD COLLEGE FUND | DORCHESTER, MA | $250,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| STANFORD UNIVERSITY | STANFORD, CA | $250,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| HIGH COUNTRY UNITED WAY | BOONE, NC | $250,000 | 2025 | PROGRAM SUPPORT |
| MYFUTURENC | RALEIGH, NC | $250,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| STOWE FAMILY YMCA | GASTONIA, NC | $200,000 | 2025 | PROGRAM SUPPORT |
| MYERS PARK BAPTIST CHURCH | CHARLOTTE, NC | $180,000 | 2025 | PROGRAM SUPPORT |
| COMMUNITIES IN SCHOOLS | CHARLOTTE, NC | $175,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| DARLINGTON SCHOOL | ROME, GA | $150,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| CRISIS ASSISTANCE MINISTRY | CHARLOTTE, NC | $150,000 | 2025 | TO ASSIST IN HEALTH AND HUMAN SERVICES |
| HEART MATH TUTORING | CHARLOTTE, NC | $125,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| CARE RING - NURSE - FAMILY PARTNERSHIP | CHARLOTTE, NC | $125,000 | 2025 | TO ASSIST IN HEALTH AND HUMAN SERVICES |
| CHILD CARE RESOURCES INC | CHARLOTTE, NC | $125,000 | 2025 | PROGRAM SUPPORT |
| NEO PHILANTHROPY INC FBO PRESS FORWARD CHARLOTTE | NEW YORK, NY | $120,000 | 2025 | PROGRAM SUPPORT |
| CHARLOTTE BILINGUAL PRESCHOOL | CHARLOTTE, NC | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| HELPS EDUCATION FUND | RALEIGH, NC | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| AUGUSTINE LITERACY PROJECT | CHARLOTTE, NC | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| UNC ASHEVILLE FUND | ASHEVILLE, NC | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| YOUNG BLACK LEADERSHIP ALLIANCE | CHARLOTTE, NC | $100,000 | 2025 | PROGRAM SUPPORT |
| CAROLINA THREAD TRAIL | CHARLOTTE, NC | $100,000 | 2025 | PROGRAM SUPPORT |
| CHARLOTTE SYMPHONY ORCHESTRA | CHARLOTTE, NC | $100,000 | 2025 | PROGRAM SUPPORT |
| APPALACHIAN STATE UNIVERSITY DISASTER RELIEF FUND | BOONE, NC | $100,000 | 2025 | TO ASSIST IN HEALTH AND HUMAN SERVICES |
| CLASSROOM CENTRAL | CHARLOTTE, NC | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| WESTERN CAROLINA UNIVERSITY EMERGENCY FUND | CULLOWHEE, NC | $100,000 | 2025 | PROGRAM SUPPORT |
| STANFORD UNIVERSITY - HOOVER INSTITUTE | STANFORD, CA | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| COLLEGE ADVISING CORPS | RALEIGH, NC | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| YEAR UP CHARLOTTE | CHARLOTTE, NC | $100,000 | 2025 | PROGRAM SUPPORT |
| CMS FOUNDATION - LOANED EXECUTIVES PROGRAM | CHARLOTTE, NC | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| CAROLINA YOUTH COALITION | CHARLOTTE, NC | $100,000 | 2025 | TO ASSIST IN EDUCATIONAL OPPORTUNITIES |
| PLANNED PARENTHOOD - SOUTH ATLANTIC | CHARLOTTE, NC | $75,000 | 2025 | TO ASSIST IN HEALTH AND HUMAN SERVICES |
| CHARLOTTE BALLET | CHARLOTTE, NC | $50,000 | 2025 | PROGRAM SUPPORT |
| CHILDREN'S THEATRE OF CHARLOTTE | CHARLOTTE, NC | $50,000 | 2025 | PROGRAM SUPPORT |
UCSF - MULTIPLE SCLEROSIS
$5,000,000TO ASSIST IN HEALTH AND HUMAN SERVICES
NATIONAL MULTIPLE SCLEROSIS SOCIETY
$5,000,000TO ASSIST IN HEALTH AND HUMAN SERVICES
FFTC - CHARLOTTE SYMPHONY ORCHESTRA ENDOWMENT CAMPAIGN
$2,500,000PROGRAM SUPPORT
DARLINGTON SCHOOL - CAPITAL CAMPAIGN
$1,000,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
HARVARD BUSINESS SCHOOL
$1,000,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
NC SCHOOL OF SCIENCE & MATHEMATICS FOUNDATION
$750,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
SAFE ALLIANCE - THE UMBRELLA CENTER CAPITAL CAMPAIGN
$500,000PROGRAM SUPPORT
FIDELITY CHARITABLE
$330,000PROGRAM SUPPORT
TRINITY EPISCOPAL SCHOOL - CAPITAL CAMPAIGN
$300,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
WELLESLEY COLLEGE
$300,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
SAMARITAN'S PURSE
$250,000PROGRAM SUPPORT
FFTC - READ CHARLOTTE
$250,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
MAYO CLINIC
$250,000TO ASSIST IN HEALTH AND HUMAN SERVICES
THE FOUNDATION FOR NC A&T STATE UNIVERSITY
$250,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
UNITED WAY OF GREATER CHARLOTTE
$250,000PROGRAM SUPPORT
CMS FOUNDATION - MUSICAL INSTRUMENTS PROGRAM
$250,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
TEACH FOR AMERICA
$250,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
COMMUNITY FOUNDATION OF WESTERN CAROLINA
$250,000PROGRAM SUPPORT
CAROLINA FARM TRUST
$250,000PROGRAM SUPPORT
HARVARD UNIVERSITY FBO HARVARD COLLEGE FUND
$250,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
STANFORD UNIVERSITY
$250,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
HIGH COUNTRY UNITED WAY
$250,000PROGRAM SUPPORT
MYFUTURENC
$250,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
STOWE FAMILY YMCA
$200,000PROGRAM SUPPORT
MYERS PARK BAPTIST CHURCH
$180,000PROGRAM SUPPORT
COMMUNITIES IN SCHOOLS
$175,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
DARLINGTON SCHOOL
$150,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
CRISIS ASSISTANCE MINISTRY
$150,000TO ASSIST IN HEALTH AND HUMAN SERVICES
HEART MATH TUTORING
$125,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
CARE RING - NURSE - FAMILY PARTNERSHIP
$125,000TO ASSIST IN HEALTH AND HUMAN SERVICES
CHILD CARE RESOURCES INC
$125,000PROGRAM SUPPORT
NEO PHILANTHROPY INC FBO PRESS FORWARD CHARLOTTE
$120,000PROGRAM SUPPORT
CHARLOTTE BILINGUAL PRESCHOOL
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
HELPS EDUCATION FUND
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
AUGUSTINE LITERACY PROJECT
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
UNC ASHEVILLE FUND
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
YOUNG BLACK LEADERSHIP ALLIANCE
$100,000PROGRAM SUPPORT
CAROLINA THREAD TRAIL
$100,000PROGRAM SUPPORT
CHARLOTTE SYMPHONY ORCHESTRA
$100,000PROGRAM SUPPORT
APPALACHIAN STATE UNIVERSITY DISASTER RELIEF FUND
$100,000TO ASSIST IN HEALTH AND HUMAN SERVICES
CLASSROOM CENTRAL
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
WESTERN CAROLINA UNIVERSITY EMERGENCY FUND
$100,000PROGRAM SUPPORT
STANFORD UNIVERSITY - HOOVER INSTITUTE
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
COLLEGE ADVISING CORPS
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
YEAR UP CHARLOTTE
$100,000PROGRAM SUPPORT
CMS FOUNDATION - LOANED EXECUTIVES PROGRAM
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
CAROLINA YOUTH COALITION
$100,000TO ASSIST IN EDUCATIONAL OPPORTUNITIES
PLANNED PARENTHOOD - SOUTH ATLANTIC
$75,000TO ASSIST IN HEALTH AND HUMAN SERVICES
CHARLOTTE BALLET
$50,000PROGRAM SUPPORT
CHILDREN'S THEATRE OF CHARLOTTE
$50,000PROGRAM SUPPORT