The Helmsley Trust concentrates its giving on biomedical research and health-system capacity with a strong emphasis on inflammatory bowel disease/Crohn's research and Type 1 diabetes access and treatment. It also invests in health infrastructure and capacity-building in Israel and in global health programs (neglected tropical diseases, WASH, rural connectivity) that expand access to care. Grants span academic translational science, hospital equipment and facility upgrades, and programmatic support to organizations building delivery systems for affordable medicines and diabetes care.
The Leona M and Harry B Helmsley Charitable Trust’s largest recent grants show a clear pattern of health-system building: $22.5 million to The End Fund Inc. for neglected tropical disease work reaching the last mile, and $15.6 million to Blue Circle Health Inc. for underserved communities with Type 1 diabetes. Those two grants capture the trust’s mix of global health delivery and diabetes access work. The trust also backs major medical infrastructure projects, including cancer centers, rehabilitation facilities, emergency medicine upgrades, and equipment investments in hospitals and health systems. Recent awards range from large translational and clinical initiatives to capital-heavy grants for radiotherapy, MRI, surgical units, and prehospital care. The foundation gives at national scale, with grants landing in U.S. states, Israel, and other countries, and its recent portfolio includes repeated support for health programs that combine research, infrastructure, and service delivery. In the most recent grants, it also funded rural connectivity, WASH, and emergency response projects that extend care to remote or underserved settings.
Type 1 diabetes is one of the trust’s core areas. It gave $15.6 million to Blue Circle Health Inc. to create Blue Circle Health for underserved communities with T1D, and $6.75 million to Mass General Brigham for accelerating progress and promoting quality T1D care through the Global PEN-PLUS partnership. The trust also funds emergency care and first-response capacity. Grants include $12.6 million to the Regents of the University of Minnesota for the Minnesota First Responder AED Project and $6.63 million to the Nevada Department of Health and Human Services for a similar AED project. On the infrastructure side, it supported $9.91 million to Shaare Zedek Medical Center for the Helmsley Cancer Center and $6.44 million to Commonwealth Healthcare Corporation for an MRI and medical equipment upgrade project. The trust also backed global health delivery through $7.02 million to Engineering Ministries International USA for the Alaska WASH Project.
Typical grants are substantial: the distribution sits at $156,612 at the 25th percentile, $382,594 at the median, and $876,022 at the 75th percentile. The recent list also shows several multi-year relationships, including repeated awards to Mass General Brigham, Shaare Zedek Medical Center, Engineering Ministries International USA, and Stichting the Ocean Cleanup across different years. The trust is a regular funder and also makes program-related investments. Its public programs are invitation-based rather than open to unsolicited applications, with active program areas covering Type 1 diabetes, Crohn’s disease, Israel, New York City, rural healthcare, and vulnerable children in Sub-Saharan Africa.
$346.8M
$7.1B
$497.3M
$422.2M
Most grants fall between $157K and $876K, with a median of $383K.
25th Percentile
$157K
Median
$383K
75th Percentile
$876K
SARAH E PAUL
Top 10 recipient countries by grant volume for Leona M and Harry B Helmsley Charitable Trust.
| Rank | Country | Grants | Total | Share |
|---|---|---|---|---|
| 1 | United StatesDomestic | 1,676 | $1.4B | 70.2% |
| 2 |
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Large, multi-year and repeat grants concentrated on a set of institutional partners (research universities, specialty hospitals, and targeted NGOs). Funding mixes sizable research awards and capital/equipment grants with program grants for scale-up and delivery; relatively concentrated across recurring grantees rather than many one-off small gifts.
Notable grantees: Helmholtz Zentrum Muenchen (GmbH), Shaare Zedek Medical Center, Blue Circle Health Inc, T1D Exchange Inc, Crohn's & Colitis Foundation
Most grants go to U.S. recipients, and New York accounts for 17% of grants even though the trust gives most often in Colorado by recipient count. Recent awards also went to Israel, including Jerusalem, Tzrifin, and Tiberias, as well as to Boston, Minneapolis, and Colorado Springs in the U.S. The recipient-country distribution reaches beyond the U.S. and Israel into the UK, Germany, Canada, Australia, the Netherlands, Belgium, Switzerland, and France, showing a broad international footprint.
Its recent grants emphasize health-system capacity, Type 1 diabetes access and treatment, Crohn’s disease research, cancer and radiotherapy infrastructure, emergency response, and global health delivery. Named awards include support for the Helmsley Cancer Center at Shaare Zedek Medical Center, the Nevada First Responder AED Project, and the Alaska WASH Project.
No. The active grant programs listed for Type 1 diabetes, Crohn’s disease, Israel, New York City, Rural Healthcare, and Vulnerable Children in Sub-Saharan Africa all indicate that it does not accept unsolicited requests.
Its grant-size distribution is relatively large for a foundation with a median of $382,594. The 25th percentile is $156,612 and the 75th percentile is $876,022, which indicates a portfolio that includes many mid-sized grants and a substantial number of larger awards.
No. Its giving is national in scope, with recipients in many U.S. states and in countries including Israel, the UK, Germany, Canada, Australia, the Netherlands, Belgium, Switzerland, and France. The recipient mix shows both domestic and international grantmaking.
Active programs include Type 1 diabetes, Crohn’s disease, Israel, New York City, Rural Healthcare, and Vulnerable Children in Sub-Saharan Africa. The recent-grants list also shows related work in emergency care, WASH, cancer infrastructure, and medical equipment upgrades.
CHIEF EXECUTIVE OFFICER
2025
Source: IRS Form 990-PF, fiscal year 2025.
| 233 |
| $324.7M |
9.8% |
| 3 | United Kingdom | 112 | $43.3M | 4.7% |
| 4 | Germany | 80 | $83.5M | 3.4% |
| 5 | Canada | 63 | $40.8M | 2.6% |
| 6 | Australia | 59 | $63.8M | 2.5% |
| 7 | Netherlands | 29 | $32.2M | 1.2% |
| 8 | Belgium | 28 | $14.2M | 1.2% |
| 9 | Switzerland | 22 | $30.3M | 0.9% |
| 10 | France | 15 | $4.3M | 0.6% |
Recipient country reflects the grantee's headquarters per IRS 990-PF and Schedule F filings, not the program's implementation country.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| AMERICAN HEART ASSOCIATION INC | DALLAS, TX | $6,966,024 | 2026 | AMERICAN HEART ASSOCIATION CENTER FOR TELEHEALTH |
| MASS GENERAL BRIGHAM FOR THE BRIGHAM AND WOMEN'S HOSPITAL | BOSTON, MA | $6,753,638 | 2026 | ACCELERATING PROGRESS AND PROMOTING QUALITY T1D CARE FOR THE POOREST BILLION THROUGH THE GLOBAL PEN-PLUS PARTNERSHIP |
| BEN-GURION UNIVERSITY OF THE NEGEV | BEER SHEVA | $5,785,714 | 2026 | CONSTRUCTION OF THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST COMPUTER SCIENCE BUILDING |
| HADASSAH MEDICAL ORGANIZATION | JERUSALEM | $5,265,160 | 2026 | EQUIPPING THE NEW HADASSAH - HELMSLEY MEDICAL CENTER, NETIVOT |
| THE QUEENS MEDICAL CENTER | HONOLULU, HI | $5,000,000 | 2026 | THE QUEEN'S MEDICAL CENTER - WEST OAHU CANCER CENTER EXPANSION |
| KAPIOLANI HEALTH FOUNDATION | HONOLULU, HI | $5,000,000 | 2026 | MARTHA B. SMITH CANCER & INFUSION CENTER AT KAPIOLANI MEDICAL CENTER FOR WOMEN & CHILDREN |
| BILLINGS CLINIC FOUNDATION | BILLINGS, MT | $5,000,000 | 2026 | BILLINGS CLINIC SURGICAL INTENSIVE CARE UNIT |
| STICHTING THE OCEAN CLEANUP | ROTTERDAM | $5,000,000 | 2026 | DEVELOP AND SCALE TECHNOLOGIES TO RID THE OCEANS OF PLASTICS |
| TEL AVIV SOURASKY MEDICAL CENTER - ICHILOV HOSPITAL | TEL AVIV | $4,879,510 | 2026 | CONSTRUCTION OF THE SHELTERED -5 FLOOR OF THE NORTH TOWER |
| BAPTIST MEDICAL CENTRE | NALERIGU | $4,505,896 | 2026 | ELEVATING MATERNAL AND PEDIATRIC HEALTHCARE |
| BLUE CIRCLE HEALTH INC | WILMINGTON, DE | $4,470,844 | 2026 | DEVELOPMENT OF BLUE CIRCLE HEALTH |
| BLUE CIRCLE HEALTH INC | WILMINGTON, DE | $4,470,843 | 2026 | DEVELOPMENT OF BLUE CIRCLE HEALTH |
| ALTRU HEALTH SYSTEM | GRAND FORKS, ND | $4,214,824 | 2026 | ALTRU HEALTH SYSTEM ULTRASOUND INITIATIVE |
| BLUE CIRCLE HEALTH INC | WILMINGTON, DE | $3,975,887 | 2026 | DEVELOPMENT OF BLUE CIRCLE HEALTH |
| WILCOX HEALTH FOUNDATION | LIHUE, HI | $3,944,163 | 2026 | WILCOX MEDICAL CENTER EQUIPMENT REVITALIZATION PROJECT |
| ST ALEXIUS MEDICAL CENTER | BISMARCK, ND | $3,799,563 | 2026 | CHI ST. ALEXIUS HEALTH ULTRASOUND INITIATIVE |
| HILLEL YAFFE MEDICAL CENTER | HADERA | $3,536,258 | 2026 | CONSTRUCTION OF PET-CT INSTITUTE |
| STATE OF NEVADA DEPARTMENT OF DIVISION OF STATE PARKS | CARSON CITY, NV | $3,500,000 | 2026 | VALLEY OF FIRE VISITOR CENTER |
| THE BROAD INSTITUTE INC | CAMBRIDGE, MA | $3,497,605 | 2026 | NOVEL THERAPEUTIC APPROACHES FOR CROHNS DISEASE |
| BAR ILAN UNIVERSITY IN ISRAEL | RAMAT GAN | $3,348,125 | 2026 | THE LEONA M. AND HARRY B. HELMSLEY ENERGY PROTOTYPE LAB AT BAR-ILAN UNIVERSITY |
| ST LUKE HEALTH CARE FOUNDATION | WEST CHICAGO, IL | $3,293,350 | 2026 | HOPE CENTER FOR WOMEN AND CHILDREN |
| FAIRVIEW HEALTH SERVICES | MINNEAPOLIS, MN | $3,176,500 | 2026 | IMPROVING SURVIVAL OUTCOMES THROUGH UNIVERSITY OF MINNESOTA MEDICAL CENTER ECMO CENTER OF EXCELLENCE |
| HILLEL YAFFE MEDICAL CENTER | HADERA | $3,158,400 | 2026 | EYE INSTITUTE AND AMBULATORY SURGERY CENTER |
| WORLD HEALTH ORGANIZATION | GENEVA | $3,129,504 | 2026 | STRENGTHENING THE CAPACITY OF THE GLOBAL DIABETES COMPACT |
| WORLD HEALTH ORGANIZATION | GENEVA | $3,126,083 | 2026 | STRENGTHENING INTEGRATED PREVENTION AND CONTROL OF CHRONIC AND SEVERE NCDS IN THE WHO AFRICAN REGION, USING T1D, SCD, ARF, AND RHD AS ENTRY POINTS |
| TRINITY HEALTH | MINOT, ND | $3,020,087 | 2026 | TRINITY HEALTH ULTRASOUND INITIATIVE |
| THE WEIZMANN INSTITUTE OF SCIENCE | REHOVOT | $3,000,000 | 2026 | EARLY CHILDHOOD DEVELOPMENT AND COMMUNITY CENTER AT THE WEIZMANN INSTITUTE OF SCIENCE |
| MASS GENERAL BRIGHAM FOR THE BRIGHAM AND WOMEN'S HOSPITAL | BOSTON, MA | $2,905,515 | 2026 | REAL-TIME POST-OP TOUCHLESS, REMOTE MONITORING IN CROHNS DISEASE THE SAPPHIRE TRIAL |
| CLINTON HEALTH ACCESS INITIATIVE INC | BOSTON, MA | $2,811,261 | 2026 | IMPROVING MEDICAL OXYGEN PRODUCTION AND UTILIZATION |
| BNAI ZION MEDICAL CENTER | HAIFA | $2,764,483 | 2026 | DEVELOPMENT OF THE HELMSLEY CARDIOVASCULAR CARE UNIT |
| NEW YORK UNIVERSITY | NEW YORK, NY | $2,756,847 | 2026 | TAMALE EDUCATION AND INNOVATION CENTER FOR HEALTH |
| CLALIT HEALTH SERVICES | TEL AVIV | $2,658,835 | 2026 | A NEW NEONATAL CENTER FOR ISRAELS SOUTHERN PERIPHERY AT SOROKA MEDICAL CENTER |
| THE ACADEMIC COLLEGE AT TEL-HAI | UPPER GALILEE | $2,600,000 | 2026 | THE HELMSLEY RESEARCH AND INNOVATION WING IN THE TEL-HAI COMPUTER SCIENCE BUILDING. |
| LIVING WATER INTERNATIONAL | STAFFORD, TX | $2,574,349 | 2026 | SCALING INTEGRATED WASH SERVICES |
| T1D EXCHANGE INC | BOSTON, MA | $2,567,417 | 2026 | EQUITABLE HEALTH AND PSYCHOSOCIAL OUTCOMES FOR INDIVIDUALS LIVING WITH T1D THROUGH THE T1D EXCHANGE QUALITY IMPROVEMENT COLLABORATIVE AND REGISTRY |
| CLALIT HEALTH SERVICES | TEL AVIV | $2,541,165 | 2026 | A NEW NEONATAL CENTER FOR ISRAELS SOUTHERN PERIPHERY AT SOROKA MEDICAL CENTER |
| AMERICAN HEART ASSOCIATION INC | DALLAS, TX | $2,521,277 | 2026 | MISSION LIFELINE STROKE IOWA |
| SHAARE ZEDEK MEDICAL CENTER | JERUSALEM | $2,500,000 | 2026 | DEVELOPMENT OF THE HELMSLEY SURGICAL WING |
| SHAARE ZEDEK MEDICAL CENTER | JERUSALEM | $2,500,000 | 2026 | DEVELOPMENT OF THE HELMSLEY COMPREHENSIVE CARDIAC CARE CENTER |
| INT'L BANK FOR RECONSTRUCTION & DEV AND INT'L DEVELOPMENT ASSOC | WASHINGTON, DC | $2,500,000 | 2026 | HEALTH SYSTEM TRANSFORMATION AND RESILIENCE MULTI-DONOR TRUST FUND - NONCOMMUNICABLE DISEASE PARTNERSHIP GENERAL OPERATING SUPPORT |
| INTERNATIONAL WATER MANAGEMENT INSTITUTE | BATTARAMULLA | $2,449,440 | 2026 | DIGITAL INNOVATIONS FOR A WATER SECURE AFRICA |
| ANN & ROBERT H LURIE CHILDRENS HOSPITAL OF CHICAGO | CHICAGO, IL | $2,325,006 | 2026 | IMPLEMENTATION AND DISSEMINATION OF TOOLS TO HARNESS CGM DATA TO ACCELERATE ADOPTION OF POPULATION HEALTH IN T1D |
| BRIDGES TO PROSPERITY INC | DENVER, CO | $2,306,101 | 2026 | TRANSFORMATIVE CONNECTIVITY IN RURAL ZAMBIA |
| ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | NEW YORK CITY, NY | $2,303,337 | 2026 | DEFINING THE PRE-DISEASE PHASE OF CROHNS DISEASE PREDICT AND PREVENT |
| GAY AND LESBIAN COMMUNITY CENTER OF SOUTHERN NEVADA INC | LAS VEGAS, NV | $2,267,929 | 2026 | CAPITAL SUPPORT FOR THE CENTER |
| THE ASSOCIATION FOR THE RESIDENT AND COMMUNITY IN RAMAT HANEGEV | RAMAT HANEGEV | $2,241,803 | 2026 | RAMAT HANEGEV SENIOR CITIZEN CENTER |
| BILLINGS CLINIC FOUNDATION | BILLINGS, MT | $2,215,173 | 2026 | BILLINGS CLINIC TRANSFER CENTER |
| THE ASSOCIATION FOR THE BETTERMENT OF ESHKOL REGION RESIDENTS | KIBBUTZ MAGEN | $2,203,283 | 2026 | BE'ERI AGRICULTURAL EQUIPMENT |
| GALILEE MEDICAL CENTER | NAHARIYA | $2,200,000 | 2026 | RENOVATION OF TWO FLOORS OF THE INTERNAL MEDICINE BUILDING AT GALILEE MEDICAL CENTER |
| THE END FUND INC | NEW YORK, NY | $2,117,400 | 2026 | TACKLING TRACHOMA SURGERY DISPARITIES |
AMERICAN HEART ASSOCIATION INC
$6,966,024AMERICAN HEART ASSOCIATION CENTER FOR TELEHEALTH
MASS GENERAL BRIGHAM FOR THE BRIGHAM AND WOMEN'S HOSPITAL
$6,753,638ACCELERATING PROGRESS AND PROMOTING QUALITY T1D CARE FOR THE POOREST BILLION THROUGH THE GLOBAL PEN-PLUS PARTNERSHIP
BEN-GURION UNIVERSITY OF THE NEGEV
$5,785,714CONSTRUCTION OF THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST COMPUTER SCIENCE BUILDING
HADASSAH MEDICAL ORGANIZATION
$5,265,160EQUIPPING THE NEW HADASSAH - HELMSLEY MEDICAL CENTER, NETIVOT
THE QUEEN'S MEDICAL CENTER - WEST OAHU CANCER CENTER EXPANSION
MARTHA B. SMITH CANCER & INFUSION CENTER AT KAPIOLANI MEDICAL CENTER FOR WOMEN & CHILDREN
STICHTING THE OCEAN CLEANUP
$5,000,000DEVELOP AND SCALE TECHNOLOGIES TO RID THE OCEANS OF PLASTICS
TEL AVIV SOURASKY MEDICAL CENTER - ICHILOV HOSPITAL
$4,879,510CONSTRUCTION OF THE SHELTERED -5 FLOOR OF THE NORTH TOWER
BAPTIST MEDICAL CENTRE
$4,505,896ELEVATING MATERNAL AND PEDIATRIC HEALTHCARE
BLUE CIRCLE HEALTH INC
$4,470,844DEVELOPMENT OF BLUE CIRCLE HEALTH
BLUE CIRCLE HEALTH INC
$4,470,843DEVELOPMENT OF BLUE CIRCLE HEALTH
BLUE CIRCLE HEALTH INC
$3,975,887DEVELOPMENT OF BLUE CIRCLE HEALTH
WILCOX MEDICAL CENTER EQUIPMENT REVITALIZATION PROJECT
ST ALEXIUS MEDICAL CENTER
$3,799,563CHI ST. ALEXIUS HEALTH ULTRASOUND INITIATIVE
HILLEL YAFFE MEDICAL CENTER
$3,536,258CONSTRUCTION OF PET-CT INSTITUTE
STATE OF NEVADA DEPARTMENT OF DIVISION OF STATE PARKS
$3,500,000VALLEY OF FIRE VISITOR CENTER
BAR ILAN UNIVERSITY IN ISRAEL
$3,348,125THE LEONA M. AND HARRY B. HELMSLEY ENERGY PROTOTYPE LAB AT BAR-ILAN UNIVERSITY
IMPROVING SURVIVAL OUTCOMES THROUGH UNIVERSITY OF MINNESOTA MEDICAL CENTER ECMO CENTER OF EXCELLENCE
HILLEL YAFFE MEDICAL CENTER
$3,158,400EYE INSTITUTE AND AMBULATORY SURGERY CENTER
WORLD HEALTH ORGANIZATION
$3,129,504STRENGTHENING THE CAPACITY OF THE GLOBAL DIABETES COMPACT
WORLD HEALTH ORGANIZATION
$3,126,083STRENGTHENING INTEGRATED PREVENTION AND CONTROL OF CHRONIC AND SEVERE NCDS IN THE WHO AFRICAN REGION, USING T1D, SCD, ARF, AND RHD AS ENTRY POINTS
TRINITY HEALTH
$3,020,087TRINITY HEALTH ULTRASOUND INITIATIVE
THE WEIZMANN INSTITUTE OF SCIENCE
$3,000,000EARLY CHILDHOOD DEVELOPMENT AND COMMUNITY CENTER AT THE WEIZMANN INSTITUTE OF SCIENCE
MASS GENERAL BRIGHAM FOR THE BRIGHAM AND WOMEN'S HOSPITAL
$2,905,515REAL-TIME POST-OP TOUCHLESS, REMOTE MONITORING IN CROHNS DISEASE THE SAPPHIRE TRIAL
CLINTON HEALTH ACCESS INITIATIVE INC
$2,811,261IMPROVING MEDICAL OXYGEN PRODUCTION AND UTILIZATION
BNAI ZION MEDICAL CENTER
$2,764,483DEVELOPMENT OF THE HELMSLEY CARDIOVASCULAR CARE UNIT
CLALIT HEALTH SERVICES
$2,658,835A NEW NEONATAL CENTER FOR ISRAELS SOUTHERN PERIPHERY AT SOROKA MEDICAL CENTER
THE ACADEMIC COLLEGE AT TEL-HAI
$2,600,000THE HELMSLEY RESEARCH AND INNOVATION WING IN THE TEL-HAI COMPUTER SCIENCE BUILDING.
T1D EXCHANGE INC
$2,567,417EQUITABLE HEALTH AND PSYCHOSOCIAL OUTCOMES FOR INDIVIDUALS LIVING WITH T1D THROUGH THE T1D EXCHANGE QUALITY IMPROVEMENT COLLABORATIVE AND REGISTRY
CLALIT HEALTH SERVICES
$2,541,165A NEW NEONATAL CENTER FOR ISRAELS SOUTHERN PERIPHERY AT SOROKA MEDICAL CENTER
SHAARE ZEDEK MEDICAL CENTER
$2,500,000DEVELOPMENT OF THE HELMSLEY SURGICAL WING
SHAARE ZEDEK MEDICAL CENTER
$2,500,000DEVELOPMENT OF THE HELMSLEY COMPREHENSIVE CARDIAC CARE CENTER
INT'L BANK FOR RECONSTRUCTION & DEV AND INT'L DEVELOPMENT ASSOC
$2,500,000HEALTH SYSTEM TRANSFORMATION AND RESILIENCE MULTI-DONOR TRUST FUND - NONCOMMUNICABLE DISEASE PARTNERSHIP GENERAL OPERATING SUPPORT
INTERNATIONAL WATER MANAGEMENT INSTITUTE
$2,449,440DIGITAL INNOVATIONS FOR A WATER SECURE AFRICA
IMPLEMENTATION AND DISSEMINATION OF TOOLS TO HARNESS CGM DATA TO ACCELERATE ADOPTION OF POPULATION HEALTH IN T1D
BRIDGES TO PROSPERITY INC
$2,306,101TRANSFORMATIVE CONNECTIVITY IN RURAL ZAMBIA
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
$2,303,337DEFINING THE PRE-DISEASE PHASE OF CROHNS DISEASE PREDICT AND PREVENT
CAPITAL SUPPORT FOR THE CENTER
THE ASSOCIATION FOR THE RESIDENT AND COMMUNITY IN RAMAT HANEGEV
$2,241,803RAMAT HANEGEV SENIOR CITIZEN CENTER
THE ASSOCIATION FOR THE BETTERMENT OF ESHKOL REGION RESIDENTS
$2,203,283BE'ERI AGRICULTURAL EQUIPMENT
GALILEE MEDICAL CENTER
$2,200,000RENOVATION OF TWO FLOORS OF THE INTERNAL MEDICINE BUILDING AT GALILEE MEDICAL CENTER
THE END FUND INC
$2,117,400TACKLING TRACHOMA SURGERY DISPARITIES
Financiamiento actual y próximo de Leona M and Harry B Helmsley Charitable Trust al que tu organización sin fines de lucro podría postularse.
Administrado por Civica Foundation
¿Quién puede postularse? Rural and critical access hospitals meeting program criteria, as defined by the Federal Office of Rural Health Policy, in the nine pilot states. Participation costs are supported through philanthropic funding and no annual membership commitment is required.
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