These foundations have a track record of funding human services work in South Carolina, based on IRS 990 grant data. Use the list below to find funders aligned with your mission, then sign up free to see how well your nonprofit fits each one.
Open Grant Opportunities
Live programs funding human services in South Carolina that your nonprofit can apply to now.
Open nowCloses in 6 days (Nov 18, 2026)Award: $10K – $150K
Food insecurityFood pantry capacityFood service equipment and infrastructure+6 more
Who can apply: Open to Network U.S. member agencies in good standing. Applicants must have 10% of the project budget already committed for consideration and must provide 70% of the project funding to be eligible to receive the remaining 30% match. Projects must address capital needs that increase food-service capacity, efficiency, geographic reach, scope, or number of clients served. Staffing and in-kind support do not count toward capital budget costs. Funded agencies must submit progress and final reports, financial documentation, proof of match, and a one-year post-operations narrative.
Humanities educationCollege readinessHigher education access+3 more
Who can apply: Colleges and universities interested in launching Knowledge for Freedom programs may apply. Programs must bring low-income high school students to campus for an intensive summer humanities seminar taught by college faculty, use transformative texts, provide college application assistance and a civic engagement or public service project, engage alumni, and present faculty leadership and a sustainability plan. General Teagle guidelines require U.S.-based tax-exempt 501(c)(3) organizations and domestic activities.
Arts and cultureEducation and leadershipEnvironmental sustainability+2 more
Who can apply: Eligible nonprofit organizations serving the listed geographic areas may apply. Grants are not provided to individuals, for trips or tours, solely religious, social, or fraternal organizations, charities that redistribute funds to other charitable organizations except recognized united-fund type organizations, K-12 schools, political organizations or organizations primarily influencing legislation or promoting a particular ideological viewpoint, or operating budget deficits.
Women and children’s health, safety, and welfareFamily strengtheningAnimal welfare+3 more
Who can apply: Applicants must be nonprofit organizations with current IRS designation and certification of 501(c)(3) status. Proposals must align with at least one Foundation focus area and include a signed proposal letter, current operating budget and applicable program budget, most recently filed signed Form 990, current board listing, and, if available, an independent audited financial statement and annual report. Letters of Intent, event sponsorship or endorsement proposals, and funding requests for individuals are not processed.
Scientific researchEducationYouth development+4 more
Who can apply: Applicants generally must be formally organized non-individual entities with an EIN and must meet the foundation's specific grant guidelines. Wells Fargo's private-foundation process indicates that applicants should locate the foundation and complete an online eligibility quiz before applying. Specific eligibility requirements for the Madigan Edward Foundation were not provided.
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