The Reyes Foundation concentrates large, strategic gifts to major universities and academic medical centers, with a clear emphasis on capital projects and building research/clinical capacity. Their philanthropy repeatedly supports university campus development and named medical funds—particularly in pediatric and cancer research—suggesting a priority on advancing academic medicine and institutional infrastructure over small community grants.
The J Christopher and Anne N Reyes Foundation makes some of its largest recent commitments to university capital projects and academic medicine, with repeated support for the University of Notre Dame’s Central Campus Development Plan and for medical funds at Northwestern Memorial Foundation. Those patterns point to a grantmaker that backs institutional capacity: campus construction, renovation, research infrastructure, and endowed or named funds inside major universities and medical systems. Recent giving shows a mix of large one-time payments and installment-style pledge support. The foundation gave $4,166,600 to the University of Notre Dame for the Central Campus Development Plan in 2025, and it also made six- and seven-figure gifts to Northwestern Memorial Foundation for the Reyes Fund of Excellence in Academic Medicine across 2023, 2024, and 2025. Pediatric health is another recurring thread through the Lurie Children’s Foundation’s For Every Child Fund, while Mayo Clinic received support for the J. Christopher and Anne N. Reyes High Risk Breast Cancer Registry and Biorepository Fund. Other grants reach cultural, youth, and community institutions, but the dominant pattern remains large institutional support tied to named projects and funds.
In higher education, the foundation backed campus development and renovation through the University of Notre Dame, including $2,287,151 for McKenna Hall Renovation & Campus Crossroads in 2023. It also supported Northwestern University with a $1,000,000 2024 pledge payment, showing that its university giving includes pledged support as well as project-based gifts. In pediatric health, Lurie Children’s Foundation received multiple grants for the For Every Child Fund, including $2,911,058 in 2025 and $2,717,716 in 2024. In breast cancer research infrastructure, Mayo Clinic received $1,997,563 in 2025 for the J. Christopher and Anne N. Reyes High Risk Breast Cancer Registry and Biorepository Fund. The foundation also supported community and leadership programming through Ronald McDonald House of Charities’ Leadership Development Fund and Cristo Rey St Martin College Prep’s Cornerstone Campaign.
The typical grant size is sizable: the 25th percentile is $23,750, the median is $60,000, and the 75th percentile is $200,000. The recent record also includes repeated payments to the same recipients across multiple years, which points to pledge-style or multi-year support rather than isolated gifts. The foundation is an operating grantmaker rather than a program-related investment vehicle, and it funds individuals as well as institutions. The latest 990 year on file is 2025.
$18.2M
$242K
$18.2M
$18.2M
Most grants fall between $24K and $200K, with a median of $60K.
25th Percentile
$24K
Median
$60K
75th Percentile
$200K
About 15% of grants go to recipients in IL.
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Concentrated, high-value grants to a small set of repeat institutional grantees; mix of multi-grant relationships and pledge payments that fund capital projects and designated research/clinical initiatives rather than many small, dispersed grants.
Notable grantees: University of Notre Dame, Lurie Children’s Foundation, Northwestern Memorial Foundation, Mayo Clinic, Northwestern University
Giving is national, with all recent grants landing in the United States. Illinois is the top state by grant count, driven in part by repeated awards in Chicago and nearby communities such as Evanston and Waukegan. Florida also appears in the recent record through West Palm Beach and Hobe Sound. Outside Illinois and Florida, recent grants reached Notre Dame, Indiana; Rochester, Minnesota; and Alexandria, Virginia.
It repeatedly funds university campus development, academic medicine, pediatric health, and research infrastructure. Recent examples include the University of Notre Dame’s Central Campus Development Plan, Northwestern Memorial Foundation’s Reyes Fund of Excellence in Academic Medicine, and Mayo Clinic’s High Risk Breast Cancer Registry and Biorepository Fund.
Yes. Several recipients appear across multiple years, including the University of Notre Dame, Lurie Children’s Foundation, Northwestern Memorial Foundation, Boys & Girls Club of Martin County, and Ronald McDonald House of Charities. The repeated 2023, 2024, and 2025 payments suggest installment or pledge-based support.
The 25th percentile is $23,750, the median grant is $60,000, and the 75th percentile is $200,000. The recent record also includes much larger institutional gifts in the seven-figure range.
Illinois is the top state by grant count. Recent Illinois recipients include organizations in Chicago, Evanston, and Waukegan, which indicates a strong concentration there even though the foundation’s grants are national overall.
No. While universities and medical institutions are central, the recent record also includes Boys & Girls Club of Martin County, Norton Museum of Art, Lyric Opera of Chicago, Cristo Rey St Martin College Prep, and Ronald McDonald House of Charities.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| UNIVERSITY OF NOTRE DAME | NOTRE DAME, IN | $4,166,600 | 2025 | CENTRAL CAMPUS DEVELOPMENT PLAN |
| LURIE CHILDREN'S FOUNDATION | CHICAGO, IL | $2,911,058 | 2025 | FOR EVERY CHILD FUND |
| MAYO CLINIC | ROCHESTER, MN | $1,997,563 | 2025 | J. CHRISTOPHER AND ANNE N. REYES HIGH RISK BREAST CANCER REGISTRY AND BIOREPOSITORY FUND |
| UNIVERSITY OF NOTRE DAME | NOTRE DAME, IN | $1,623,689 | 2025 | CENTRAL CAMPUS DEVELOPMENT PLAN |
| NORTHWESTERN MEMORIAL FOUNDATION | CHICAGO, IL | $1,215,600 | 2025 | REYES FUND OF EXCELLENCE IN ACADEMIC MEDICINE |
| NORTHWESTERN UNIVERSITY | EVANSTON, IL | $1,000,000 | 2025 | 2024 PLEDGE PAYMENT |
| UNIVERSITY OF NOTRE DAME | NOTRE DAME, IN | $993,237 | 2025 | GENERAL SUPPORT |
| BOYS & GIRLS CLUB OF MARTIN COUNTY | HOBE SOUND, FL | $600,000 | 2025 | ANNUAL GIFT 2024 |
| UNIVERSITY OF NOTRE DAME | NOTRE DAME, IN | $576,311 | 2025 | CENTRAL CAMPUS DEVELOPMENT PLAN |
| ENTITLEMENTS HOW | ALEXANDRIA, VA | $269,119 | 2025 | GENERAL SUPPORT |
| RONALD MCDONALD HOUSE CHARITIES | CHICAGO, IL | $250,000 | 2025 | 2019 PLEDGE PAYMENT |
| ENTITLEMENTS HOW | ALEXANDRIA, VA | $232,405 | 2025 | GENERAL SUPPORT |
| UNIVERSITY OF MARYLAND COLLEGE PARK | COLLEGE PARK, MD | $200,000 | 2025 | REYES ENDOWED CHAIRS IN ELECTRICAL AND COMPUTER ENGINEERING AND MECHANICAL ENGINEERING - PAYMENT 2 OF 5 |
| NORTON MUSEUM OF ART | WEST PALM BEACH, FL | $200,000 | 2025 | 2024 PLEDGE |
| NATIONAL MUSUEM OF WOMEN IN ARTS | WASHINGTON, DC | $200,000 | 2025 | GENERAL SUPPORT |
| CATHOLIC CHURCH EXTENSION SOCIETY | CHICAGO, IL | $200,000 | 2025 | GENERAL SUPPORT |
| REDF | SAN FRANCISCO, CA | $173,208 | 2025 | STRATEGIC GROWTH CAMPAIGN |
| ANDERSON RANCH ARTS CENTER | SNOWMASS VILLAGE, CO | $150,000 | 2025 | REYES COMMUNITY ENGAGEMENT INITIATIVE |
| UNIVERSITY OF CHICAGO | CHICAGO, IL | $100,000 | 2025 | 2017 PLEDGE |
| UNIVERSITY OF CHICAGO | CHICAGO, IL | $100,000 | 2025 | 2017 PLEDGE |
| SHIRLEY RYAN ABILITYLAB | CHICAGO, IL | $100,000 | 2025 | GENERAL SUPPORT |
| UNIVERSITY OF NOTRE DAME | NOTRE DAME, IN | $100,000 | 2025 | GENERAL SUPPORT |
| INNER CITY SCHOLARSHIP FUND | NEW YORK, NY | $100,000 | 2025 | GENERAL SUPPORT |
| MARGARET HACKETT FAMILY CENTER | CHICAGO, IL | $97,146 | 2025 | 2020 PLEDGE PAYMENT |
| LURIE CHILDREN'S FOUNDATION | CHICAGO, IL | $92,872 | 2025 | FOR EVERY CHILD FUND |
| BOYS & GIRLS CLUB OF MARTIN COUNTY | HOBE SOUND, FL | $75,000 | 2025 | GENERAL SUPPORT |
| FOREST BLUFF SCHOOL | LAKE BLUFF, IL | $50,000 | 2025 | GENERAL SUPPORT |
| WENDY NOVAK DIABETES INSTITUTE | LOUISVILLE, KY | $50,000 | 2025 | GENERAL SUPPORT |
| HOBE SOUND COMMUNITY CHEST | HOBE SOUND, FL | $25,000 | 2025 | GENERAL SUPPORT |
| THE ART INSTITUTE OF CHICAGO | CHICAGO, IL | $25,000 | 2025 | GENERAL SUPPORT |
| GENEVA LAKE CONSERVANCY | WILLIAMS BAY, WI | $25,000 | 2025 | GENERAL SUPPORT |
| GENEVA LAKE WATER SAFETY PATROL | WILLIAMS BAY, WI | $25,000 | 2025 | GENERAL SUPPORT |
| INSPIRATIONAL MINISTRIES | WALWORTH, WI | $25,000 | 2025 | GENERAL SUPPORT |
| THE SOCIETY OF THE FOUR ARTS | PALM BEACH, FL | $25,000 | 2025 | GENERAL SUPPORT |
| ACCELERATE INSTITUTE | CHICAGO, IL | $25,000 | 2025 | GENERAL SUPPORT |
| LAKE GENEVA COUNTRY CLUB FOUNDATION | LAKE GENEVA, WI | $25,000 | 2025 | GENERAL SUPPORT |
| REDF | SAN FRANCISCO, CA | $20,734 | 2025 | 2019 PLEDGE PAYMENT |
| ABILITYPATH | REDWOOD CITY, CA | $15,000 | 2025 | GENERAL SUPPORT |
| MAYO CLINIC | ROCHESTER, MN | $12,572 | 2025 | GENERAL SUPPORT |
| JIM SAUNDERS FUND | KAILUA KONA, HI | $10,000 | 2025 | GENERAL SUPPORT |
| YERKES OBSERVATORY | WILLIAMS BAY, WI | $10,000 | 2025 | GENERAL SUPPORT |
| THE 1916 REDAN FOUNDATION | LAKE BLUFF, IL | $10,000 | 2025 | GENERAL SUPPORT |
| JUPITER ISLAND MEDICAL CLINIC INC | HOBE SOUND, FL | $10,000 | 2025 | GENERAL SUPPORT |
| WALWORTH CITY FOOD AND DIAPER BANK | ELKHORN, WI | $10,000 | 2025 | GENERAL SUPPORT |
| THE CHICAGO CLUB PRESERVATION FDN | CHICAGO, IL | $10,000 | 2025 | 2020 PLEDGE PAYMENT |
| AJGA CAROLINA CUP | BRASELTON, GA | $10,000 | 2025 | GENERAL SUPPORT |
| TREEHOUSE CHILD AND FAMILY CENTER | ELKHORN, WI | $10,000 | 2025 | GENERAL SUPPORT |
| UNIVERSITY OF NOTRE DAME | NOTRE DAME, IN | $6,763 | 2025 | GENERAL SUPPORT |
| YERKES OBSERVATORY | WILLIAMS BAY, WI | $5,000 | 2025 | GENERAL SUPPORT |
| JUPITER ISLAND MEDICAL CLINIC INC | HOBE SOUND, FL | $5,000 | 2025 | GENERAL SUPPORT |
UNIVERSITY OF NOTRE DAME
$4,166,600CENTRAL CAMPUS DEVELOPMENT PLAN
LURIE CHILDREN'S FOUNDATION
$2,911,058FOR EVERY CHILD FUND
MAYO CLINIC
$1,997,563J. CHRISTOPHER AND ANNE N. REYES HIGH RISK BREAST CANCER REGISTRY AND BIOREPOSITORY FUND
UNIVERSITY OF NOTRE DAME
$1,623,689CENTRAL CAMPUS DEVELOPMENT PLAN
NORTHWESTERN MEMORIAL FOUNDATION
$1,215,600REYES FUND OF EXCELLENCE IN ACADEMIC MEDICINE
NORTHWESTERN UNIVERSITY
$1,000,0002024 PLEDGE PAYMENT
UNIVERSITY OF NOTRE DAME
$993,237GENERAL SUPPORT
BOYS & GIRLS CLUB OF MARTIN COUNTY
$600,000ANNUAL GIFT 2024
UNIVERSITY OF NOTRE DAME
$576,311CENTRAL CAMPUS DEVELOPMENT PLAN
ENTITLEMENTS HOW
$269,119GENERAL SUPPORT
RONALD MCDONALD HOUSE CHARITIES
$250,0002019 PLEDGE PAYMENT
ENTITLEMENTS HOW
$232,405GENERAL SUPPORT
UNIVERSITY OF MARYLAND COLLEGE PARK
$200,000REYES ENDOWED CHAIRS IN ELECTRICAL AND COMPUTER ENGINEERING AND MECHANICAL ENGINEERING - PAYMENT 2 OF 5
NORTON MUSEUM OF ART
$200,0002024 PLEDGE
NATIONAL MUSUEM OF WOMEN IN ARTS
$200,000GENERAL SUPPORT
CATHOLIC CHURCH EXTENSION SOCIETY
$200,000GENERAL SUPPORT
REDF
$173,208STRATEGIC GROWTH CAMPAIGN
ANDERSON RANCH ARTS CENTER
$150,000REYES COMMUNITY ENGAGEMENT INITIATIVE
UNIVERSITY OF CHICAGO
$100,0002017 PLEDGE
UNIVERSITY OF CHICAGO
$100,0002017 PLEDGE
SHIRLEY RYAN ABILITYLAB
$100,000GENERAL SUPPORT
UNIVERSITY OF NOTRE DAME
$100,000GENERAL SUPPORT
INNER CITY SCHOLARSHIP FUND
$100,000GENERAL SUPPORT
MARGARET HACKETT FAMILY CENTER
$97,1462020 PLEDGE PAYMENT
LURIE CHILDREN'S FOUNDATION
$92,872FOR EVERY CHILD FUND
BOYS & GIRLS CLUB OF MARTIN COUNTY
$75,000GENERAL SUPPORT
FOREST BLUFF SCHOOL
$50,000GENERAL SUPPORT
WENDY NOVAK DIABETES INSTITUTE
$50,000GENERAL SUPPORT
HOBE SOUND COMMUNITY CHEST
$25,000GENERAL SUPPORT
THE ART INSTITUTE OF CHICAGO
$25,000GENERAL SUPPORT
GENEVA LAKE CONSERVANCY
$25,000GENERAL SUPPORT
GENEVA LAKE WATER SAFETY PATROL
$25,000GENERAL SUPPORT
INSPIRATIONAL MINISTRIES
$25,000GENERAL SUPPORT
THE SOCIETY OF THE FOUR ARTS
$25,000GENERAL SUPPORT
ACCELERATE INSTITUTE
$25,000GENERAL SUPPORT
LAKE GENEVA COUNTRY CLUB FOUNDATION
$25,000GENERAL SUPPORT
REDF
$20,7342019 PLEDGE PAYMENT
ABILITYPATH
$15,000GENERAL SUPPORT
MAYO CLINIC
$12,572GENERAL SUPPORT
JIM SAUNDERS FUND
$10,000GENERAL SUPPORT
YERKES OBSERVATORY
$10,000GENERAL SUPPORT
THE 1916 REDAN FOUNDATION
$10,000GENERAL SUPPORT
JUPITER ISLAND MEDICAL CLINIC INC
$10,000GENERAL SUPPORT
WALWORTH CITY FOOD AND DIAPER BANK
$10,000GENERAL SUPPORT
THE CHICAGO CLUB PRESERVATION FDN
$10,0002020 PLEDGE PAYMENT
AJGA CAROLINA CUP
$10,000GENERAL SUPPORT
TREEHOUSE CHILD AND FAMILY CENTER
$10,000GENERAL SUPPORT
UNIVERSITY OF NOTRE DAME
$6,763GENERAL SUPPORT
YERKES OBSERVATORY
$5,000GENERAL SUPPORT
JUPITER ISLAND MEDICAL CLINIC INC
$5,000GENERAL SUPPORT