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    5. Open Molecular Software Foundation
    Logo de Open Molecular Software Foundation

    Open Molecular Software Foundation

    ActivoPublic CharityScience & Technology
    Davis, CASitio webEIN: 86-25366641 declaraciones registradas

    About Open Molecular Software Foundation

    Advance humanity’s ability to understand and shape the physical world through open technologies.

    Focus Areas

    computational molecular sciencesopen source scientific softwarecomputational chemistryprotein structure prediction and designfree energy methods / alchemical calculationscommunity infrastructure and governance

    Who They Fund

    open-source projects and communitiessoftware developers and maintainersorganizations relying on open-source software (nonprofits, public sector, startups)

    Funding Style

    infrastructure/platform developmentecosystem building

    About Open Molecular Software Foundation

    A single $863,000 grant to Rosetta Commons Foundation anchored the Open Molecular Software Foundation’s most recent giving and points to its central role in open scientific software. The foundation funds computational molecular sciences, with grants that support software platform development, research, and open-source ecosystem work rather than individuals or program-related investments. Its active programs show two related approaches: direct grantmaking through the OMSF Grant Program and fiscally sponsored support for hosted projects, where the foundation provides back-office services, HR support, strategic advising, fundraising assistance, event and fellowship support, and governance guidance. Recent awards also show that the foundation works with universities as well as open-source communities. UC Irvine received $35,000 for research, Johns Hopkins University received $32,522 for research, and Arizona State University received $7,069 for open-source ecosystem development. Across these grants, the foundation’s activity centers on building the infrastructure and community conditions needed for molecular science software to be maintained and extended over time.

    What Open Molecular Software Foundation Funds

    In computational molecular sciences, the foundation’s grantmaking supports both software and the people maintaining it. One recent award gave $35,000 to UC Irvine for research, while another gave $32,522 to Johns Hopkins University for research, showing that academic collaborators are part of its portfolio. The foundation also funded Arizona State University with $7,069 for open-source ecosystem development, which aligns with its stated emphasis on open source scientific software and ecosystem building. Beyond direct grants, OMSF’s hosted-project model adds operational support for open-source communities through accounting, contracts, insurance, HR, strategic advising, fundraising assistance, and governance guidance. Its active programs also point to work in reproducibility, FAIR practices, interoperability, and community infrastructure.

    How Open Molecular Software Foundation Gives

    The recent grant sizes are highly skewed: the 25th percentile is $7,069, the median is $33,761, and the 75th percentile is $249,011. One grant of $863,000 sits far above the rest. The foundation is a public charity and a regular funder, not a DAF or individual-giving vehicle. Its active programs show both recurring grantmaking and structured support for hosted projects, and one of those programs explicitly accepts unsolicited applications. The recent-grants list includes only U.S. recipients, but the foundation’s program geography is described as global.

    Financial Snapshot

    Annual Giving

    $938K

    Total Assets

    $3.5M

    Total Revenue

    $5.4M

    Total Expenses

    $5.3M

    Geographic Reach

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    Política de privacidadTérminos de servicioEstado del sistema
    capacity building
    collaborative/partnership support

    Topics

    software platform developmentopen source ecosystem developmentdeveloper tools & workflowscommunity governance & maintainer supportinteroperability & open standardssustainable maintainer funding

    Where Open Molecular Software Foundation Makes Grants

    Recent grants in the data went entirely to U.S. recipients, with 4 grants and 100% in the United States. Baltimore appears twice, through Rosetta Commons Foundation and Johns Hopkins University. Other recipient cities include Irvine and Tempe. The foundation’s program descriptions are global, including hosted projects and the OMSF Grant Program, even though the recent grants listed here were all domestic.

    Frequently Asked Questions About Open Molecular Software Foundation

    What kinds of work does Open Molecular Software Foundation support?

    It supports computational molecular sciences, open source scientific software, protein structure prediction and design, free energy methods and alchemical calculations, and community infrastructure and governance. The active programs also emphasize software infrastructure, reproducibility, FAIR practices, interoperability, and maintainer support.

    Does Open Molecular Software Foundation accept unsolicited applications?

    Yes, at least some programs do. The OMSF Hosted Projects / Fiscal Sponsorship program accepts unsolicited requests, and the OMSF Grant Program is also marked as accepting unsolicited applications. Other listed programs, including the NSF POSE-related projects and Rosetta POSE, do not accept unsolicited applications.

    What is the typical grant size?

    Among the recent grants provided, the 25th percentile is $7,069, the median is $33,761, and the 75th percentile is $249,011. The distribution includes one much larger grant of $863,000, so the average would not describe the pattern well.

    Which organizations received recent grants?

    Recent grants went to Rosetta Commons Foundation, UC Irvine, Johns Hopkins University, and Arizona State University. The awards covered software platform development, research, and open-source ecosystem development.

    Is the foundation focused on one geography?

    Its program descriptions are global, and the recent-grants list includes only U.S. recipients. The listed recipient cities are Baltimore, Irvine, and Tempe, with Baltimore appearing twice.

    Latest 990 Filing

    2025

    Source: IRS Form 990-PF, fiscal year 2025.

    Recent Grants

    Most recent grants reported to the IRS.

    RecipientLocationAmountYearPurpose
    Rosetta Commons FoundationBaltimore, MD$863,0002025Software Platform Development
    UC IrvineIrvine, CA$35,0002025Research
    Johns Hopkins UniversityBaltimore, MD$32,5222025Research
    Arizona State UniversityTempe, CA$7,0692025Open Source Ecosystem Development

    Rosetta Commons Foundation

    $863,000
    Baltimore, MD2025

    Software Platform Development

    UC Irvine

    $35,000
    Irvine, CA2025

    Research

    Johns Hopkins University

    $32,522
    Baltimore, MD2025

    Research

    Arizona State University

    $7,069
    Tempe, CA2025

    Open Source Ecosystem Development

    Oportunidades de Subvenciones Abiertas

    Financiamiento actual y próximo de Open Molecular Software Foundation al que tu organización sin fines de lucro podría postularse.

    Abierta ahoraRecepción continua / abierta

    OMSF Hosted Projects / Fiscal Sponsorship

    Open-source softwareComputational molecular sciencesScientific software infrastructure+2 más

    ¿Quién puede postularse? Projects should operate in computational molecular sciences, commit to open-source licensing and public code availability, have a governance model, and present a plan for financial sustainability. OMSF may require alignment with its bylaws and directed fund agreements.

    Fecha límite: No stated deadlines; no fixed application period documented.

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