The Job Research Foundation is a focused biomedical funder dedicated to research into Autosomal Dominant Hyper-IgE Syndrome (Job syndrome) and related STAT3-mediated immune dysfunctions, with an emphasis on translational approaches such as CRISPR/gene-editing and stem-cell–based therapies. It supports leading academic and government research centers worldwide, funding both mechanistic studies of lung, skin and gastrointestinal pathology and preclinical work toward curative gene-repair strategies. Grants are targeted to specialized labs and clinical-research programs rather than broad service or advocacy groups.
Focus Areas
Translational CRISPR/gene-editing approaches for Job (Hyper-IgE) syndromeSTAT3-focused basic and mechanistic immunology research (lung, skin, GI pathology)Ex vivo autologous hematopoietic stem-cell gene repair as curative therapy for Job syndromeQuality-of-life and clinical outcomes research for AD-HIES patients (respiratory, dermatologic, psychological)Funding of leading biomedical research centers and national institutes conducting preclinical and early translational studies
Who They Fund
patients with autosomal dominant hyper‑IgE syndrome (AD‑HIES / Job syndrome)
About Job Research Foundation
Job Research Foundation’s grantmaking is tightly centered on Autosomal Dominant Hyper-IgE Syndrome, with recent awards supporting research on STAT3-mediated immune dysfunction, lung pathology, and gene-repair strategies. The foundation backs a small set of specialized biomedical programs rather than a broad mix of causes, and its recent grants show a consistent two-year, $100,000-per-award pattern.
That focus appears across multiple institutions and research angles. In 2025, the foundation funded Aarhus University Department of Biomedicine for next-generation CRISPR/Cas-based ex vivo gene editing of autologous hematopoietic stem cells as a curative treatment of Job syndrome. It also supported the Garvan Institute of Medical Research for work on immune dysregulation in Job syndrome, including STAT3-mediated host defense, humoral immunity, and immune-mediated lung pathology. Earlier awards went to Helmholtz Zentrum Munchen for alveolar function, regeneration, and gene repair in Job syndrome, and to the Icahn School of Medicine at Mount Sinai for cross-regulation of STAT signaling pathways in lung pathology of experimental HIES.
What Job Research Foundation Funds
A major thread in the foundation’s portfolio is gene-editing research. It gave $100,000 to University of Freiburg to carry out research for treating hyper IgE syndrome by genome editing in CD34+ hematopoietic stem and progenitor cells, and another $100,000 to National Institute of Allergy and Infectious Diseases for next-generation CRISPR base editing approaches to treat Job syndrome.
Lung disease is another recurring topic. The foundation funded Icahn School of Medicine at Mount Sinai for cross-regulation of STAT signaling pathways in lung pathology of experimental HIES, while Helmholtz Zentrum Munchen studied alveolar function, regeneration, and gene repair. It also supported the Garvan Institute of Medical Research on immune-mediated lung pathology tied to STAT3-mediated host defense and humoral immunity.
Patient-centered work appears as well. The University of Newcastle Upon Tyne received support for quality-of-life research on respiratory, dermatological, and psychological health in AD-HIES.
How Job Research Foundation Gives
Typical grant size is fixed at $100,000, with p25, median, and p75 all at $100,000. The recent grants list shows repeated awards to the same recipients across multiple years, including Garvan Institute of Medical Research, Helmholtz Zentrum Munchen, Icahn School of Medicine at Mount Sinai, and National Institute of Allergy and Infectious Diseases. The foundation is a regular funder, not a DAF, and it does not fund individuals. Its active grant programs are competitive research grants, and the program descriptions say unsolicited applications are accepted.
Financial Snapshot
Annual Giving
$300K
Total Assets
$21K
Total Revenue
$1K
Total Expenses
$354K
Typical Grant Size
Most grants fall between $100K and $100K, with a median of $100K.
25th Percentile
$100K
Median
$100K
75th Percentile
$100K
Geographic Reach
Regional2 states funded
Intensidad de financiamiento
BajaAlta
Sede
Funding intensity
LowHigh
Where Job Research Foundation Funds
Top 5 recipient countries by grant volume for Job Research Foundation.
Rank
Country
Grants
Total
Share
1
Germany
9
$900K
39.1%
2
United StatesDomestic
Deep Analysis
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EIN (identificación fiscal): 35-7211744Último Formulario 990: 2025Activos totales: 21 mil US$3 declaraciones registradasEncuentra su declaración 990 completa →
individuals eligible for autologous HSC gene therapy
patients with respiratory, dermatologic and psychological morbidity from AD‑HIES
Giving Approach
Concentrated, disease-specific giving: relatively few large grants (multiple six-figure awards) often repeated to the same top research institutions and government labs; funding is international and focused on high-impact, translational biomedical research rather than small or general-interest nonprofits.
Funding Style
translational researchpreclinical and mechanistic researchcurative gene-therapy developmentpatient-centered outcomes research
Notable grantees: Icahn School of Medicine at Mount Sinai, National Institute of Allergy and Infectious Diseases (NIAID), Garvan Institute of Medical Research, Helmholtz Zentrum München, Columbia University
Topics
AD‑HIES (Job syndrome) pathogenesis and treatmentSTAT3 signaling and cross-regulation in lung pathologyCRISPR/Cas base editing and ex vivo HSC gene editingalveolar function, regeneration and gene repairimmune dysregulation, humoral immunity and host defensefibroblast‑specific STAT3 role in pneumatocele and GI perforationquality of life impacts on respiratory, dermatologic and psychological health
Where Job Research Foundation Makes Grants
Grants land in a small international set of research hubs. New York City, Bethesda, Sydney, and Neuherberg all appear in the recent grants list, along with Freiburg and Newcastle upon Tyne. The recipient-country distribution is split across Germany and the United States at 31.2% each, followed by Asia at 18.8%, the UK at 12.5%, and Denmark at 6.2%. The foundation’s HQ is in New York, but half of its grants go to recipients in New York State.
Frequently Asked Questions About Job Research Foundation
What does Job Research Foundation fund?
It funds research into Autosomal Dominant Hyper-IgE Syndrome, also called Job syndrome, with work on STAT3-mediated immune dysfunction, pulmonary complications, gene editing, and translational therapies. Recent grants included studies of immune dysregulation, alveolar regeneration and gene repair, and CRISPR base editing.
How large are its typical grants?
The recent grant data shows a fixed size: p25, median, and p75 are all $100,000. The listed recent awards are also all $100,000.
Does Job Research Foundation accept unsolicited applications?
Yes. The active research grant program descriptions say the foundation accepts unsolicited applications for its competitive research grants.
Are its grants mostly one-time awards or repeated over time?
The recent grants list shows repeat support to the same institutions across multiple years. Garvan Institute of Medical Research, Helmholtz Zentrum Munchen, Icahn School of Medicine at Mount Sinai, and National Institute of Allergy and Infectious Diseases each appear more than once.
What kind of research approaches does it support?
The foundation supports both basic and translational biomedical research. Named projects include CRISPR/Cas-based ex vivo gene editing of autologous hematopoietic stem cells, next-generation CRISPR base editing, STAT signaling in lung pathology, and quality-of-life research for AD-HIES patients.
Latest 990 Filing
2025
Source: IRS Form 990-PF, fiscal year 2025.
5
$500K
21.7%
3
Australia
4
$400K
17.4%
4
United Kingdom
3
$300K
13.0%
5
Denmark
2
$200K
8.7%
Recipient country reflects the grantee's headquarters per IRS 990-PF and Schedule F filings, not the program's implementation country.
Oportunidades de Subvenciones Abiertas
Financiamiento actual y próximo de Job Research Foundation al que tu organización sin fines de lucro podría postularse.
Abierta ahoraCierra en 19 días (16 oct 2026)Monto: Hasta 200 mil US$
2027 Grant Guidelines
Job Syndrome researchCauses of Job SyndromeTreatments for Job Syndrome+2 más
¿Quién puede postularse? Open to researchers worldwide. Research must be selected and supervised by a qualified public charity; funds will be disbursed to the institution, not the individual researcher. Organizations that discriminate on the basis of race, gender, religion, ethnicity or sexual orientation are not considered. Previous applicants may apply in subsequent years to extend their research.
Fecha límite: Submission deadline for all grant applications is Friday, October 16, 2026. Grants will be awarded between December and January.
Abierta ahoraCierra en 19 días (16 oct 2026)Monto: Hasta 200 mil US$
Job Research Foundation Research Grants (annual funding round)
Job Syndrome / AD-HIESRare multisystem immunodeficiency disordersCauses and treatments of Job Syndrome+1 más
¿Quién puede postularse? Open to researchers worldwide, including previous grantees and previous applicants. Research must be selected and supervised by a qualified public charity; funds are disbursed to the institution rather than the individual researcher. Applicants must submit a personal statement, detailed research proposal, budget and justification, curriculum vitae or biosketch, primary mentor biosketch, and applicable IACUC or IRB approval plan. The Foundation will not consider organizations that discriminate on the basis of race, gender, religion, ethnicity, or sexual orientation.
Fecha límite: The 2026 application deadline is October 16, 2026. The application page states that the 2026 process is closed, while the 2026 funding announcement lists the October 16 deadline. Awardees are expected to be announced in January 2027.
Abierta ahoraCierra en 19 días (16 oct 2026)Monto: Hasta 200 mil US$
Research Grants for Job Syndrome (Job Research Foundation Research Grant)
Job Syndrome (AD-HIES)Rare multisystem immunodeficiency disordersCauses and treatments of Job Syndrome+2 más
¿Quién puede postularse? Open to researchers worldwide, including previous applicants and grantees. Research must be selected and supervised by a qualified public charity; funds are disbursed to that institution rather than to the individual researcher. Applicants must submit a personal statement, detailed research proposal, budget and justification, applicable IACUC or IRB approval plan, CV or biosketch, and primary mentor biosketch. The Foundation will not consider inquiries from organizations that discriminate on the basis of race, gender, religion, ethnicity, or sexual orientation.
Fecha límite: October 16, 2026 for the 2027 grant cycle; grants are anticipated to be available annually.
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CARRYING OUT RESEARCH INTO NEXT GENERATION CRISPR/CAS-BASED EX VIVO GENE EDITING OF AUTOLOGOUS HEMATOPOIETIC STEM CELLS AS A CURATIVE TREATMENT OF JOB SYNDROME
CARRYING OUT RESEARCH INTO CROSS REGULATION OF STAT SIGNALING PATHWAYS IN LUNG PATHOLOGY OF EXPERIMENTAL HIES
GARVAN INSTITUTE OF MEDICAL RESEARCH
SYDNEY, SY
$100,000
2025
CARRYING OUT RESEARCH INTO IMMUNE DYSREGULATION IN JOB SYNDROME- ELUCIDATING MECHANISMS OF STAT3- MEDIATED HOST DEFENSE, HUMORAL IMMUNITY AND IMMUNE- MEDIATED LUNG PATHOLOGY
HELMHOLTZ ZENTRUM MUNCHEN
NEUHERBERG, NE
$100,000
2024
CARRYING OUT RESEARCH INTO THE EVALUATION OF ALVEOLAR FUNCTION, REGENERATION AND GENE REPAIR IN JOB SYNDROME
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
BETHESDA, MD
$100,000
2024
CARRYING OUT RESEARCH INTO THE NEXT-GENERATION CRISPR BASE EDITING APPROACHES TO TREAT JOB SYNDROME.
GARVAN INSTITUTE OF MEDICAL RESEARCH
SYDNEY, SY
$100,000
2024
CARRYING OUT RESEARCH INTO IMMUNE DYSREGULATION IN JOB SYNDROME- ELUCIDATING MECHANISMS OF STAT3- MEDIATED HOST DEFENSE, HUMORAL IMMUNITY AND IMMUNE- MEDIATED LUNG PATHOLOGY
CARRYING OUT RESEARCH INTO CROSS REGULATION OF STAT SIGNALING PATHWAYS IN LUNG PATHOLOGY OF EXPERIMENTAL HIES
COLUMBIA UNIVERSITY
NEW YORK, NY
$100,000
2023
TO CARRY OUT RESEARCH INTO THE ROLE OF FIBEROBLAST SPECIFIC STAT3 EXPRESSION IN PNEUMATOCELE DEVELOPMENT AND GASTROINTESTINAL PERFORATION IN AD-HIES
HELMHOLTZ ZENTRUM MUNCHEN
NEUHERBERG, NE
$100,000
2023
CARRYING OUT RESEARCH INTO THE EVALUATION OF ALVEOLAR FUNCTION, REGENERATION AND GENE REPAIR IN JOB SYNDROME
UNIVERSITY OF FREIBURG
FREIBURG, FR
$100,000
2023
TO CARRY OUT RESEARCH FOR TREATING HYPERIGESYNDROME BY GENOME EDITING IN CD34+ HEMATOPOIETIC STEM AND PROGENITOR CELLS.
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
BETHESDA, MD
$100,000
2023
CARRYING OUT RESEARCH INTO THE NEXT-GENERATION CRISPR BASE EDITING APPROACHES TO TREAT JOB SYNDROME.
UNIVERSITY OF NEWCASTLE UPON TYNE
—
$100,000
2023
CARRYING OUT RESEARCH INTO THE QUALITY OF LIFE OF PATIENTS WITH AD-HIES, WITH PARTICULAR FOCUS ON THE IMPACT OF TREATMENT ON RESPIRATORY, DERMATOLOGICAL AND PSYCHOLOGICAL HEALTH.
AARHUS UNIVERSITY DEPARTMENT OF BIOMEDICINE
$100,000
DENMARK2025
CARRYING OUT RESEARCH INTO NEXT GENERATION CRISPR/CAS-BASED EX VIVO GENE EDITING OF AUTOLOGOUS HEMATOPOIETIC STEM CELLS AS A CURATIVE TREATMENT OF JOB SYNDROME
CARRYING OUT RESEARCH INTO CROSS REGULATION OF STAT SIGNALING PATHWAYS IN LUNG PATHOLOGY OF EXPERIMENTAL HIES
GARVAN INSTITUTE OF MEDICAL RESEARCH
$100,000
SYDNEY, SY2025
CARRYING OUT RESEARCH INTO IMMUNE DYSREGULATION IN JOB SYNDROME- ELUCIDATING MECHANISMS OF STAT3- MEDIATED HOST DEFENSE, HUMORAL IMMUNITY AND IMMUNE- MEDIATED LUNG PATHOLOGY
HELMHOLTZ ZENTRUM MUNCHEN
$100,000
NEUHERBERG, NE2024
CARRYING OUT RESEARCH INTO THE EVALUATION OF ALVEOLAR FUNCTION, REGENERATION AND GENE REPAIR IN JOB SYNDROME
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
$100,000
BETHESDA, MD
2024
CARRYING OUT RESEARCH INTO THE NEXT-GENERATION CRISPR BASE EDITING APPROACHES TO TREAT JOB SYNDROME.
GARVAN INSTITUTE OF MEDICAL RESEARCH
$100,000
SYDNEY, SY2024
CARRYING OUT RESEARCH INTO IMMUNE DYSREGULATION IN JOB SYNDROME- ELUCIDATING MECHANISMS OF STAT3- MEDIATED HOST DEFENSE, HUMORAL IMMUNITY AND IMMUNE- MEDIATED LUNG PATHOLOGY
CARRYING OUT RESEARCH INTO CROSS REGULATION OF STAT SIGNALING PATHWAYS IN LUNG PATHOLOGY OF EXPERIMENTAL HIES
COLUMBIA UNIVERSITY
$100,000
NEW YORK, NY2023
TO CARRY OUT RESEARCH INTO THE ROLE OF FIBEROBLAST SPECIFIC STAT3 EXPRESSION IN PNEUMATOCELE DEVELOPMENT AND GASTROINTESTINAL PERFORATION IN AD-HIES
HELMHOLTZ ZENTRUM MUNCHEN
$100,000
NEUHERBERG, NE2023
CARRYING OUT RESEARCH INTO THE EVALUATION OF ALVEOLAR FUNCTION, REGENERATION AND GENE REPAIR IN JOB SYNDROME
UNIVERSITY OF FREIBURG
$100,000
FREIBURG, FR2023
TO CARRY OUT RESEARCH FOR TREATING HYPERIGESYNDROME BY GENOME EDITING IN CD34+ HEMATOPOIETIC STEM AND PROGENITOR CELLS.
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
$100,000
BETHESDA, MD2023
CARRYING OUT RESEARCH INTO THE NEXT-GENERATION CRISPR BASE EDITING APPROACHES TO TREAT JOB SYNDROME.
UNIVERSITY OF NEWCASTLE UPON TYNE
$100,000
2023
CARRYING OUT RESEARCH INTO THE QUALITY OF LIFE OF PATIENTS WITH AD-HIES, WITH PARTICULAR FOCUS ON THE IMPACT OF TREATMENT ON RESPIRATORY, DERMATOLOGICAL AND PSYCHOLOGICAL HEALTH.
