Advance pediatric health through clinical care, research, education, and community programs; support and fund innovative pediatric research from basic science through translation to clinical therapies.
Children's Hospital Of Chicago Faculty Practice Plan Inc. centers its grantmaking on pediatric research, especially work that moves from basic science into clinical therapies. A defining thread is its support for advanced therapeutics, including cellular and genetic therapies at the Stanley Manne Children's Research Institute. The recent grant record also shows repeated mission support to Lurie Children's Hospital of Chicago, with one award above $10 million and another just under $7.8 million, underscoring a funding relationship built around core institutional operations rather than isolated project grants. The foundation's program areas point to a research-driven agenda: clinical research, translational research, advanced therapeutics, and community and population health. Within that framework, it supports pilot and bridge grants for investigators, infrastructure and equipment for pediatric treatment, and endowed programs such as the Human and Molecular Genetics Research Program. Its portfolio also includes philanthropic campaign support and major gifts tied to donor-designated priorities at Lurie Children's. The pattern is consistent with a funder that uses large, institution-level grants and targeted research commitments to sustain pediatric care, research capacity, and long-term scientific programs in Chicago.
A major theme is advanced therapeutics. The Children's Research Fund made a $9 million, three-year commitment for Advanced Therapeutics research at the Stanley Manne Children's Research Institute, with a focus on cellular and genetic therapies. That places gene and cell therapy at the center of one of its signature efforts. It also supports translational genetics through long-term program building. The foundation funded a $2 million endowment to create the Human and Molecular Genetics Research Program, tied to translational genetic medicine and conditions including cystic fibrosis, spinal muscular atrophy, autism, infertility, and cancer. Another strand is research pipeline support. Through pilot and bridge grants, the funder helps investigators generate preliminary data and move toward external grant support. Its active programs also include clinical and translational research support, as well as infrastructure and equipment funding for pediatric treatment technologies.
$29.2M
$0
$15M
$10M
Most grants fall between $7.8M and $9M, with a median of $7.8M.
25th Percentile
$7.8M
Median
$7.8M
75th Percentile
$9M
About 100% of grants go to recipients in IL.
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Grant sizes are large and tightly clustered. The provided distribution shows a 25th percentile of $7,752,228, a median of $7,767,183, and a 75th percentile of $8,993,712. That points to a practice of funding at a multi-million-dollar institutional scale rather than making many small awards. The recent record also shows repeated support to the same Chicago institution across multiple years, including 2023, 2024, and 2025, which suggests ongoing relationship-based funding. The foundation does not fund individuals and does not make program-related investments. Its active programs include both unsolicited and non-unsolicited channels, but the recent grants table shows mission support as the dominant pattern.
Giving is entirely local and stays in Illinois. All recorded recipient grants in the dataset go to Chicago-based organizations, including Lurie Children's Hospital of Chicago and Lurie Children's. The top state by grant count is IL, and 100% of grants are awarded to recipients in the HQ state. The grant geography is concentrated in Chicago rather than spread across multiple states or countries. Named program activity also points to the Stanley Manne Children's Research Institute and Lurie Children's in Chicago.
Its stated focus areas are pediatric research, clinical research, translational research, advanced therapeutics such as gene and cell therapy, and community and population health. The active program list also shows support for clinical trials, pilot and bridge grants, infrastructure and equipment, and endowed research programs.
The grant-size distribution is high and narrow: p25 is $7,752,228, median is $7,767,183, and p75 is $8,993,712. Recent awards also include a $10,220,241 mission-support grant and a $7,737,273 mission-support grant.
Yes. The recent grants show recurring mission support to Lurie Children's Hospital of Chicago and Lurie Children's across 2023, 2024, and 2025. The active programs also describe ongoing support for pilot and bridge funding at the Stanley Manne Children's Research Institute.
Its giving is local and entirely in Illinois. All recorded recipient grants in the dataset went to Chicago, and the recipient country distribution is 100% US.
Some active programs accept unsolicited requests, including the Children's Research Fund — Advanced Therapeutics Commitment and Children's Research Fund — General Research Support (pilot & bridge grants). Other listed programs, such as infrastructure and equipment funding and clinical and translational research support, do not accept unsolicited requests.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| LURIE CHILDREN'S HOSPITAL OF CHICAGO | CHICAGO, IL | $10,220,241 | 2025 | MISSION SUPPORT |
| Lurie Children's Hospital of Chicago | Chicago, IL | $3,446,458 | 2025 | Mission Support |
| LURIE CHILDREN'S HOSPITAL OF CHICAGO | CHICAGO, IL | $7,767,183 | 2024 | MISSION SUPPORT |
| LURIE CHILDREN'S | CHICAGO, IL | $7,737,273 | 2023 | MISSION SUPPORT |
LURIE CHILDREN'S HOSPITAL OF CHICAGO
$10,220,241MISSION SUPPORT
Lurie Children's Hospital of Chicago
$3,446,458Mission Support
LURIE CHILDREN'S HOSPITAL OF CHICAGO
$7,767,183MISSION SUPPORT
LURIE CHILDREN'S
$7,737,273MISSION SUPPORT