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    5. Acid Maltase Deficiency Association
    Logo de Acid Maltase Deficiency Association

    Acid Maltase Deficiency Association

    ActivoPhilanthropy & VoluntarismFinancia Individuos
    SAN ANTONIO, TXSitio web2104946144

    About Acid Maltase Deficiency Association

    The foundation makes targeted, disease-specific research investments focused on Pompe disease (acid maltase deficiency). It concentrates funding into a small number of relatively large awards that support investigator-led projects, academic labs, and early-stage therapeutic developers. Grants are directed toward advancing scientific understanding and translational therapeutics rather than broad service or advocacy work.

    Focus Areas

    Pompe disease / acid maltase deficiency biomedical researchInvestigator-led clinical and translational research (clinician-scientist grants)Support for small biotech therapeutics development (enzyme replacement/gene therapy)Academic university research programs with clinical/translational focus

    Who They Fund

    people living with Pompe diseaseresearchers and clinician-scientists focused on rare genetic disorders

    Giving Approach

    Small portfolio (few grants) of relatively large, targeted awards; primarily one-off or single-year research grants distributed to individual investigators, universities, and early-stage companies; funding appears focused and international rather than broadly distributed.

    About Acid Maltase Deficiency Association

    Acid Maltase Deficiency Association Inc centers its giving on Pompe disease research and has used a small number of relatively large awards to support investigator-led science and translational therapeutic development. The latest 990 year on file shows $500,000 in annual grants against $812,819 in assets, with a typical award size of $100,000 at the median and $200,000 at the 75th percentile. Its active grant programs require that funds go directly to Pompe research and exclude indirect costs, which keeps the support tightly tied to project work. Recent awards show the foundation backing both academic and therapeutic-development settings. It gave $300,000 to Dr Benedikt Schoser for the 2021 Helen Walker Pompe Disease Research Grant, a grant name that appears in multiple cycles. It also made $100,000 awards to McMaster University and M6p Therapeutics Inc for further research of disease. The pattern points to a funder that directs capital toward scientific understanding and therapy development for acid maltase deficiency rather than broad service grants.

    What Acid Maltase Deficiency Association Funds

    The foundation’s core theme is Pompe disease, and its active Helen Walker Research Grant is built around that diagnosis. The grant is offered as a one-time research award, has appeared in multiple cycles, and can range from $150,000 to $300,000 for work directly related to Pompe research. It also supports university-based and clinician-scientist research. A 2025 grant to McMaster University was designated “to further research of disease,” which fits the foundation’s emphasis on academic and translational work. Therapeutic development is another clear thread. M6p Therapeutics Inc received $100,000 for further research of disease, showing that the foundation funds early-stage development alongside investigator-led research. The program descriptions also point to enzyme replacement and gene therapy as part of its research scope. Across these awards, the focus stays on biomedical research for rare genetic disease rather than advocacy or broad patient services.

    How Acid Maltase Deficiency Association Gives

    Grantmaking is concentrated in relatively large awards: the typical grant size is $100,000 at both the 25th percentile and median, and $200,000 at the 75th percentile. The top recent award was $300,000, which is well above the center of the distribution. The foundation makes one-time research grants, and the Helen Walker Research Grant has been offered in multiple cycles, indicating repeated programmatic giving rather than a one-off event. It also accepts unsolicited applications for that grant program. The organization funds individuals as well as institutions, which matches the mix of investigator-led and university-based support in the recent grants.

    Financial Snapshot

    Annual Giving

    $200K

    Total Assets

    $813K

    Total Revenue

    $876K

    Total Expenses

    $861K

    Typical Grant Size

    Most grants fall between $100K and $200K, with a median of $100K.

    25th Percentile

    $100K

    Median

    $100K

    75th Percentile

    $200K

    Geographic Reach

    Regional1 state funded

    About 0% of grants go to recipients in MO.

    Intensidad de financiamiento
    Baja
    Alta
    Sede
    Funding intensity
    Low
    High

    Where Acid Maltase Deficiency Association Funds

    Top 3 recipient countries by grant volume for Acid Maltase Deficiency Association.

    RankCountryGrantsTotalShare
    1Germany1$300K
    33.3%
    2Canada1$100K

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    Funding Style

    targeted disease research fundingproject-specific grantmakingtherapeutic development support

    Notable grantees: Dr. Benedikt Schoser, M6P Therapeutics, Inc., McMaster University

    Topics

    Pompe disease researchlysosomal storage disordersneuromuscular disease researchpreclinical and clinical therapeutic research

    Where Acid Maltase Deficiency Association Makes Grants

    Giving is local in scope, but the recipient list extends beyond Texas. The top state by grant count is Missouri, while 0% of grants in the data went to recipients in the HQ state of Texas. Recent grants reached Munich, Hamilton, and St. Louis. The recipient country distribution includes Germany, Canada, and the United States, each with one grant in the sample. That pattern shows a narrow, disease-specific network with awards that can land in North America and Europe.

    Frequently Asked Questions About Acid Maltase Deficiency Association

    What does Acid Maltase Deficiency Association Inc fund?

    It funds Pompe disease research, including rare-disease and lysosomal storage disease research. The active grant programs are designed for research directly related to Pompe disease, and the recent grants include support for academic research and therapeutic development.

    How large are its grants?

    The typical grant size is $100,000 at the 25th percentile and median, with the 75th percentile at $200,000. A recent award reached $300,000, showing that the foundation can make larger research commitments in selected cases.

    Can researchers apply directly?

    Yes. The Helen Walker Research Grant accepts unsolicited applications. It is a one-time research grant and the funds must be used entirely for Pompe research with no indirect costs.

    Does it fund individuals or only organizations?

    It funds individuals as well as institutions. The recent grants include an award to a named researcher, alongside grants to McMaster University and M6p Therapeutics Inc.

    Is the giving limited to one place?

    No. The data shows a local geographic scope overall, but recent grants went to recipients in Germany, Canada, and the United States. Missouri has the highest grant count in the dataset, while Texas received none.

    Latest 990 Filing

    2025

    Source: IRS Form 990-PF, fiscal year 2025.

    33.3%
    3United StatesDomestic1$100K
    33.3%

    Recipient country reflects the grantee's headquarters per IRS 990-PF and Schedule F filings, not the program's implementation country.

    Oportunidades de Subvenciones Abiertas

    Financiamiento actual y próximo de Acid Maltase Deficiency Association al que tu organización sin fines de lucro podría postularse.

    Abierta ahoraCierra en 18 días (15 oct 2026)Monto: Hasta 150 mil US$

    Helen Walker Research Grant (AMDA Research Grant)

    Pompe disease researchDisease understanding and mechanismsDiagnosis and biomarkers+6 más

    ¿Quién puede postularse? Proposed projects must be directly related to Pompe disease research. Basic, translational, clinical, and patient-centered research will be considered. Selected LOI applicants are invited to submit a full proposal.

    Fecha límite: Letters of Intent due October 15, 2026. Selected applicants will subsequently be invited to submit a full proposal.

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    Recent Grants

    Most recent grants reported to the IRS.

    RecipientLocationAmountYearPurpose
    M6P THERAPEUTICS INCST LOUIS, MO$100,0002025TO FURTHER RESEARCH OF DISEASE
    MCMASTER UNIVERSITYHAMILTON, ON$100,0002025TO FURTHER RESEARCH OF DISEASE
    DR BENEDIKT SCHOSERMUNICH, BA$300,00020242021 HELEN WALKER POMPE DISEASE RESEARCH GRANT

    M6P THERAPEUTICS INC

    $100,000
    ST LOUIS, MO2025

    TO FURTHER RESEARCH OF DISEASE

    MCMASTER UNIVERSITY

    $100,000
    HAMILTON, ON2025

    TO FURTHER RESEARCH OF DISEASE

    DR BENEDIKT SCHOSER

    $300,000
    MUNICH, BA2024

    2021 HELEN WALKER POMPE DISEASE RESEARCH GRANT