
Translate breakthrough biologically inspired engineering discoveries into real-world impact by partnering across academia, industry, investors, foundations, and philanthropists to de-risk, commercialize, and deploy technologies that improve human health and environmental sustainability.
The clearest pattern in Hansjorg Wyss Institute for Biologically Inspired Engineering at Harvard Univ Inc’s recent grantmaking is its use of large, project-level research awards and subcontracts to move biologically inspired engineering from discovery toward translation. In 2024 and 2023, the institute repeatedly funded major academic and clinical partners, including Massachusetts Institute of Technology and The Massachusetts General Hospital, through federal and non-federal sponsored awards, research collaborations, and subcontracts. That structure fits its stated role in partnering across academia, industry, investors, foundations, and philanthropists to de-risk technologies and push them toward real-world use. Recent awards also show work that connects engineering with health and environmental sustainability, with grants flowing to institutions working on diagnostics, therapeutics, medical devices, and translational platforms. The institute’s recent grantmaking includes both recurring relationships and one-off awards, with some recipients appearing in successive years and others receiving a single award. A smaller sponsorship to Nucleate Bio Inc also appears in the recent list, alongside much larger research and collaboration awards that dominate the portfolio.
Diagnostics is a visible part of the portfolio through the Diagnostics Accelerator, which is designed to partner with clinical institutions, access patient samples, and move diagnostic technologies toward clinical use and commercialization. In translational research, the institute gave $407,104 to The Regents of the University of California for federal and non-federal sponsored awards and subcontracts. Brain delivery is another active area: the Brain Targeting Program supports approaches to transport therapeutics across the blood-brain barrier, and the recent grants list includes $126,628 to CFD Research Corporation for federal sponsored awards subcontracts. Synthetic biology and biomanufacturing also appear in the program mix through the Laboratory for Sustainable Materials Research and Innovation, which is linked to sustainable materials and climate solutions. The institute also funds instrumentation support, including its Scientific Instrumentation @ Wyss Collaboratories Program for equipment placement and in-kind support.
$9.2M
$478.9M
$63.3M
$91.5M
Most grants fall between $49K and $536K, with a median of $253K.
25th Percentile
$49K
Median
$253K
75th Percentile
$536K
DONALD E INGBER
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Typical grant size is large and uneven: p25 is $48,878, the median is $252,866, and p75 is $536,148. The recent record shows repeated multi-year relationships rather than isolated gifts; several recipients appear in both 2023 and 2024, often with different award lines. The foundation is classified as a pure DAF provider, does not fund individuals, and does not make program-related investments. Its recent awards are primarily project-level sponsored awards, subcontracts, and research collaborations, with a smaller share of sponsorships and in-kind support. Unsolicited opportunities are listed for some active programs, while others are invitation-only or pre-competitive collaborations.
Giving is regional, but it is heavily concentrated in Massachusetts: 56% of grants go to recipients in the HQ state. Recent grants cluster in Boston and Cambridge, including Massachusetts Institute of Technology, The Massachusetts General Hospital, Dana-Farber Cancer Institute Inc, and Northeastern University. Outside Massachusetts, San Antonio, Texas appears twice through Metis Foundation, and Alabama is a recurring recipient state through CFD Research Corporation in Huntsville. All recent grants in the provided sample went to U.S. recipients.
The recent grants list shows awards to universities, hospitals, nonprofit research organizations, and industry collaborators. Examples include Massachusetts Institute of Technology, The Massachusetts General Hospital, Dana-Farber Cancer Institute Inc, and CFD Research Corporation, with award language centered on sponsored awards, subcontracts, and research collaborations.
The active program list includes diagnostics, therapeutics, medical devices and medtech, synthetic biology, sustainability and sustainable materials, AI and multi-omics data for translational research, and women’s health. Recent grants also show work in brain delivery, instrumentation, and translational research partnerships.
Typical grant size is substantial: p25 is $48,878, the median is $252,866, and p75 is $536,148. The recent list also includes awards above $1 million and a small sponsorship of $10,000, showing a wide spread across project types.
Yes. Several recipients appear in multiple years, including Massachusetts Institute of Technology, The Massachusetts General Hospital, Dana-Farber Cancer Institute Inc, The Brigham and Women's Hospital Inc, and Trustees of Boston University. That pattern points to recurring research relationships rather than only one-time grants.
Support is mainly through sponsored awards, subcontracts, and research collaborations. The taxonomy also includes federal sponsored awards administration, non-federal sponsored awards, subcontract management, and sponsorship/contract funding mechanisms, which fits a project-level funding model rather than unrestricted grantmaking.
2026
Source: IRS Form 990-PF, fiscal year 2026.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| ATTIVARE THERAPEUTICS INC | NATICK, MA | $1,693,161 | 2026 | NONFED SPONSORED |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | CAMBRIDGE, MA | $1,375,366 | 2026 | FED/NONFED AWARDS |
| CHILDREN'S HOSPITAL CORPORATION | BOSTON, MA | $1,173,360 | 2026 | FED/NONFED SPONSORED |
| DANA-FARBER CANCER INSTITUTE INC | BOSTON, MA | $1,102,639 | 2026 | FEDERAL SPONSORED AW |
| THE MASSACHUSETTS GENERAL HOSPITAL | BOSTON, MA | $1,096,260 | 2026 | FED/NONFED SPONSORED |
| ENPLUSONE BIOSCIENCES INC | Watertown, MA | $1,051,207 | 2026 | FEDERAL SPONSORED AW |
| THE BRIGHAM AND WOMEN'S HOSPITAL INC | BOSTON, MA | $858,606 | 2026 | FED/NONFED AWARD |
| ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | NEW YORK, NY | $260,039 | 2026 | FEDERAL SPONSORED AW |
| BETH ISRAEL DEACONESS MEDICAL CENTER | BOSTON, MA | $196,291 | 2026 | RESEARCH COLLABORATIONS |
| TRUSTEES OF BOSTON UNIVERSITY | BOSTON, MA | $193,258 | 2026 | RESEARCH COLLAB |
| THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | OAKLAND, CA | $164,224 | 2026 | FED/NONFED SPONSORED |
| TRUSTEES OF TUFTS COLLEGE | SOMERVILLE, MA | $85,528 | 2026 | FED/NONFED SPONSORED AWARDS AND SUBCONTRACTS |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | CAMBRIDGE, MA | $1,696,246 | 2025 | FED/NONFED SPONSORED |
| THE MASSACHUSETTS GENERAL HOSPITAL | BOSTON, MA | $1,488,442 | 2025 | FED/NONFED SPONSORED |
| CHILDREN'S HOSPITAL CORPORATION | BOSTON, MA | $855,018 | 2025 | FED/NONFED SPONSORED |
| ATTIVARE THERAPEUTICS INC | NATICK, MA | $843,563 | 2025 | NONFEDERAL SPONSORED |
| DANA-FARBER CANCER INSTITUTE INC | BOSTON, MA | $740,446 | 2025 | FEDERAL SPONSORED AW |
| THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | OAKLAND, CA | $491,228 | 2025 | FED/NONFED SPONSORED |
| THE BRIGHAM AND WOMEN'S HOSPITAL INC | BOSTON, MA | $395,000 | 2025 | FEDERAL SPONSORED AW |
| TRUSTEES OF BOSTON UNIVERSITY | BOSTON, MA | $362,780 | 2025 | NONFEDERAL SPONSORED |
| ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | NEW YORK, NY | $214,877 | 2025 | FEDERAL SPONSORED AW |
| METIS FOUNDATION | SAN ANTONIO, TX | $143,777 | 2025 | FEDERAL SPONSORED AW |
| TRUSTEES OF TUFTS COLLEGE | SOMERVILLE, MA | $84,214 | 2025 | NONFEDERAL SPONSORED |
| BETH ISRAEL DEACONESS MEDICAL CENTER | BOSTON, MA | $11,934 | 2025 | RESEARCH COLLABORATIONS |
| NUCLEATE BIO INC | BRIGHTON, MA | $10,000 | 2025 | SPONSORSHIP |
| Massachusetts Institute of Technology | CAMBRIDGE, MA | $1,740,429 | 2024 | Fed/NonFed awards and research collaborations |
| Metis Foundation | San Antonio, TX | $1,187,626 | 2024 | Federal sponsored awards subcontracts |
| The Massachusetts General Hospital | Boston, MA | $1,175,244 | 2024 | Federal/Non-Federal sponsored awards, subcontracts, and |
| Dana-Farber Cancer Institute Inc | Boston, MA | $795,119 | 2024 | Federal sponsored awards, subcontracts, and Research Collabrations |
| The Brigham and Women's Hospital Inc | BOSOTN, MA | $648,460 | 2024 | Fed/Nonfed SPONSORED AWARDS SUBCONTRACTS RESEARCH COLLABORATIONS |
| THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | OAKLAND, CA | $407,104 | 2024 | FED/NONFED SPONSORED AWARDS SUBCONTRACTS |
| Children's Hospital Corporation | Boston, MA | $384,748 | 2024 | Fed/Nonfed SPONSORED AWARDS SUBCONTRACTS RESEARCH COLLABORATIONS |
| Trustees of Boston University | BOSTON, MA | $316,818 | 2024 | NonFederal sponsored awards, subcontracts, Fed |
| Icahn School of Medicine at Mount Sinai | NEW YORK, NY | $188,913 | 2024 | Federal sponsored awards and subcontracts |
| Trustees of Tufts College | SOMERVILLE, MA | $63,563 | 2024 | NonFederal sponsored awards and subcontracts |
| Trustees of the University of Pennsylvania | PHILADELPHIA, PA | $39,312 | 2024 | NonFederal sponsored awards and subcontracts |
| J Craig Venter Institute | ROCKVILLE, MD | $25,803 | 2024 | Federal sponsored awards and subcontracts |
| CFD Research Corporation | Huntsville, AL | $22,182 | 2024 | Federal sponsored awards subcontracts |
| WASHINGTON UNIVERSITY | SAINT LOUIS, MO | $21,287 | 2024 | NONFEDERAL SPONSORED AWARDS SUBCONTRACTS |
| Nucleate Bio Inc | BRIGHTON, MN | $10,000 | 2024 | Sponsorship |
| Massachusetts Institute of Technology | CAMBRIDGE, MA | $1,206,107 | 2023 | Fed/NonFed awards and research collaborations |
| The Massachusetts General Hospital | Boston, MA | $916,642 | 2023 | Federal/Non-Federal sponsored awards, subcontracts, and |
| Dana-Farber Cancer Institute Inc | Boston, MA | $732,715 | 2023 | Federal sponsored awards, subcontracts, and Research Collabrations |
| Metis Foundation | San Antonio, TX | $498,710 | 2023 | Federal sponsored awards subcontracts |
| The Brigham and Women's Hospital Inc | BOSOTN, MA | $433,892 | 2023 | Federal sponsored awards, subcontracts, Nonfed |
| Northeastern University | BOSTON, MA | $410,821 | 2023 | Federal sponsored awards and subcontracts |
| Trustees of Boston University | BOSTON, MA | $365,642 | 2023 | NonFederal sponsored awards, subcontracts, Fed |
| Icahn School of Medicine at Mount Sinai | NEW YORK, NY | $324,050 | 2023 | Federal sponsored awards and subcontracts |
| Children's Hospital Corporation | Boston, MA | $187,281 | 2023 | Federal sponsored awards, subcontracts, and Research Collabrations |
| Trustees of the University of Pennsylvania | PHILADELPHIA, PA | $135,488 | 2023 | NonFederal sponsored awards and subcontracts |
ATTIVARE THERAPEUTICS INC
$1,693,161NONFED SPONSORED
THE MASSACHUSETTS GENERAL HOSPITAL
$1,096,260FED/NONFED SPONSORED
ENPLUSONE BIOSCIENCES INC
FEDERAL SPONSORED AW
THE BRIGHAM AND WOMEN'S HOSPITAL INC
$858,606FED/NONFED AWARD
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
$164,224FED/NONFED SPONSORED
THE MASSACHUSETTS GENERAL HOSPITAL
$1,488,442FED/NONFED SPONSORED
ATTIVARE THERAPEUTICS INC
$843,563NONFEDERAL SPONSORED
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
$491,228FED/NONFED SPONSORED
THE BRIGHAM AND WOMEN'S HOSPITAL INC
$395,000FEDERAL SPONSORED AW
METIS FOUNDATION
$143,777FEDERAL SPONSORED AW
NUCLEATE BIO INC
$10,000SPONSORSHIP
Massachusetts Institute of Technology
$1,740,429Fed/NonFed awards and research collaborations
Metis Foundation
$1,187,626Federal sponsored awards subcontracts
The Massachusetts General Hospital
$1,175,244Federal/Non-Federal sponsored awards, subcontracts, and
Dana-Farber Cancer Institute Inc
$795,119Federal sponsored awards, subcontracts, and Research Collabrations
The Brigham and Women's Hospital Inc
$648,460Fed/Nonfed SPONSORED AWARDS SUBCONTRACTS RESEARCH COLLABORATIONS
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
$407,104FED/NONFED SPONSORED AWARDS SUBCONTRACTS
Children's Hospital Corporation
$384,748Fed/Nonfed SPONSORED AWARDS SUBCONTRACTS RESEARCH COLLABORATIONS
Federal sponsored awards and subcontracts
NonFederal sponsored awards and subcontracts
CFD Research Corporation
$22,182Federal sponsored awards subcontracts
Nucleate Bio Inc
$10,000Sponsorship
Massachusetts Institute of Technology
$1,206,107Fed/NonFed awards and research collaborations
The Massachusetts General Hospital
$916,642Federal/Non-Federal sponsored awards, subcontracts, and
Dana-Farber Cancer Institute Inc
$732,715Federal sponsored awards, subcontracts, and Research Collabrations
Metis Foundation
$498,710Federal sponsored awards subcontracts
The Brigham and Women's Hospital Inc
$433,892Federal sponsored awards, subcontracts, Nonfed
Federal sponsored awards and subcontracts
Children's Hospital Corporation
$187,281Federal sponsored awards, subcontracts, and Research Collabrations
NonFederal sponsored awards and subcontracts