
The Conrad Prebys Foundation concentrates its philanthropic resources on high-impact scientific research in San Diego, exemplified by a single multi‑million dollar gift to the Salk Institute. The foundation appears to prefer capital support for institutions undertaking major campaigns that advance biomedical science and resilience-focused research infrastructure.
A $6.7 million grant to the Salk Institute for Biological Studies for the "Salk Campaign for the Future: Building a More Resilient World" captures The Conrad Prebys Foundation’s pattern: large, institution-level support for San Diego science. The foundation’s recent giving also reaches a similar scale at Sanford Burnham Prebys Med Disc Inst, where it backed both "Catalyst the Teaching Incubator" and research tied to breakthrough therapies for medulloblastoma and other cancers. That mix shows a funder focused on biomedical research infrastructure, translational science, and the institutions that carry it out. Other major grants point to a broad local portfolio built around health and science. The foundation has supported Rady Children’s Hospital for rapid precision medicine, La Jolla Institute for Immunology for a named flow cytometry core, and The Scripps Research Institute for immuno-oncology and cell therapy platforms. Its recent awards also include operating support for major San Diego institutions, suggesting that it uses both project-specific capital and flexible general support to sustain research capacity and related civic organizations. The result is a grantmaker centered on San Diego institutions, with a clear preference for high-dollar commitments that strengthen research environments, medical innovation, and community-serving organizations tied to health and science.
Biomedical research is the clearest throughline in the foundation’s grantmaking. It gave $1.2 million to Rady Children’s Hospital for "Rapid Precision Medicine at Rady Childrens," and $975,181 to The Scripps Research Institute for "Trispecific Antibodies: Next Generation Immuno-Oncology Platform for Treating Relapsed / Refractory Cancers." Another grant, $700,000 to The Scripps Research Institute, supported "Development of Allogeneic Switchable Chimeric Antigen Receptor T Cell Therapy." The foundation also funds research infrastructure. It awarded $1,169,810 to La Jolla Institute for Immunology for "The Conrad Prebys Foundation Flow Cytometry Core at La Jolla Institute for Immunology," and $1 million to Sanford Burnham Prebys Med Disc Inst for "Gemfinder - Serving the Underserved." Its grantmaking extends beyond lab science into arts and community well-being. San Diego Symphony Orchestra Association received $3 million for general operating support, and Ntc Foundation received $500,000 for "Building 178 Performing Arts Center (Working Title)."
$54.9M
$1.1B
$34M
$67.5M
Most grants fall between $20K and $100K, with a median of $40K.
25th Percentile
$20K
Median
$40K
75th Percentile
$100K
About 100% of grants go to recipients in CA.
GRANT OLIPHANT
CEO
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Highly concentrated giving: a single large, likely capital-focused grant to a flagship local research institution rather than many small or diversified awards.
Notable grantees: Salk Institute for Biological Studies
Typical grant size clusters around $20,000 at the 25th percentile, $40,000 at the median, and $100,000 at the 75th percentile, though the foundation also makes much larger awards for research and capital projects. The recent record shows repeated support for many of the same institutions across multiple years, including Sanford Burnham Prebys Med Disc Inst, San Diego State University Fdtn (kpbs), Sharp Healthcare Foundation, and The Campanile Foundation Sdsu. That pattern points to ongoing institutional relationships rather than one-off awards. The foundation is a regular funder, and the data also shows individuals funding through active award programs.
Grant dollars are concentrated in California, with all recorded recipient-country grants landing in the US and 100% of grants going to recipients in CA. Within the state, La Jolla and San Diego appear repeatedly among recipient locations, alongside San Marcos. The recent record also includes one out-of-state recipient in Indianapolis, IN, and another in Boston, MA, both tied to specific cultural or operating support. The overall footprint is local, with the heaviest activity in the San Diego region.
Recent grants show a strong emphasis on San Diego science and health institutions, including Salk Institute for Biological Studies, Sanford Burnham Prebys Med Disc Inst, The Scripps Research Institute, Rady Children's Hospital, and La Jolla Institute for Immunology. The foundation also funds arts, public media, and community-serving organizations.
Its grant-size distribution centers on $20,000 at the 25th percentile, a $40,000 median, and $100,000 at the 75th percentile. The recent grants list also includes much larger awards, including multimillion-dollar commitments for research, capital, and operating support.
Yes. Several recipients appear in more than one year in the recent grants list, including Sanford Burnham Prebys Med Disc Inst, San Diego State University Fdtn (kpbs), Sharp Healthcare Foundation, The Campanile Foundation Sdsu, and La Jolla Institute for Immunology. That suggests ongoing relationships with core institutions.
The foundation’s giving is local and concentrated in California. The recipient-country distribution shows all grants in the US, and 100% of grants go to recipients in CA. Recent recipient cities include La Jolla, San Diego, and San Marcos.
Yes. The foundation is marked as funding individuals, and its active programs include Prebys Leadership Awards, which recognize five leaders, and Prebys Sparx Challenge, a prize program for youth well-being solutions.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| UC SAN DIEGO FOR THE DEPOT (UC SD FDTN) | LA JOLLA, CA | $3,000,000 | 2025 | GENERAL OPERATING |
| SAN DIEGO SYMPHONY ORCHESTRA ASSOCIATION | SAN DIEGO, CA | $3,000,000 | 2025 | GENERAL OPERATING |
| SAN DIEGO STATE UNIVERSITY FDTN (KPBS) | SAN DIEGO, CA | $1,600,000 | 2025 | GENERAL OPERATING |
| THE CAMPANILE FOUNDATION SDSU | SAN DIEGO, CA | $1,500,000 | 2025 | GENERAL OPERATING |
| WGBH EDUCATIONAL FOUNDATION | BOSTON, MA | $1,000,000 | 2025 | GENERAL OPERATING |
| SHARP HEALTHCARE FOUNDATION | SAN DIEGO, CA | $1,000,000 | 2025 | GENERAL OPERATING |
| SAN DIEGO ZOO WILDLIFE ALLIANCE | SAN DIEGO, CA | $1,000,000 | 2025 | GENERAL OPERATING |
| SAN DIEGO TIJUANA WORLD DESIGN CAPITAL 2024 | SAN DIEGO, CA | $1,000,000 | 2025 | GENERAL OPERATING |
| SCRIPPS RESEARCH INSTITUTE | LA JOLLA, CA | $750,000 | 2025 | GENERAL OPERATING |
| LA JOLLA INSTITUTE FOR IMMUNOLOGY | LA JOLLA, CA | $750,000 | 2025 | GENERAL OPERATING |
| NATIONAL CONFLICT RESOLUTION CENTER | SAN DIEGO, CA | $750,000 | 2025 | GENERAL OPERATING |
| SAN DIEGO STATE UNIVERSITY FDTN (KPBS) | SAN DIEGO, CA | $622,200 | 2025 | GENERAL OPERATING |
| WORLD OF WORK FOUNDATION | EL CAJON, CA | $500,000 | 2025 | GENERAL OPERATING |
| MUSEUM OF CONTEMPORARY ART SAN DIEGO | LA JOLLA, CA | $500,000 | 2025 | GENERAL OPERATING |
| NTC FOUNDATION DBA ARTS DISTRICT LIBERTY STATION | SAN DIEGO, CA | $500,000 | 2025 | GENERAL OPERATING |
| THE SALVATION ARMY | CARSON, CA | $500,000 | 2025 | GENERAL OPERATING |
| UNIVERSITY OF SAN DIEGO | SAN DIEGO, CA | $500,000 | 2025 | GENERAL OPERATING |
| SALK INSTITUTE FOR BIOLOGICAL STUDIES | LA JOLLA, CA | $500,000 | 2025 | GENERAL OPERATING |
| SDSU (SCHOOL OF PUBLIC HEALTH) | SAN DIEGO, CA | $350,000 | 2025 | GENERAL OPERATING |
| SAN DIEGO MUSEUM OF ART | SAN DIEGO, CA | $325,000 | 2025 | GENERAL OPERATING |
| THE OLD GLOBE | SAN DIEGO, CA | $325,000 | 2025 | GENERAL OPERATING |
| LA JOLLA MUSIC SOCIETY | LA JOLLA, CA | $325,000 | 2025 | GENERAL OPERATING |
| DOWNTOWN SAN DIEGO PUBLIC SPACES FOUNDATION | SAN DIEGO, CA | $303,000 | 2025 | GENERAL OPERATING |
| SDHC BUILDING OPPORTUNITIES INC | SAN DIEGO, CA | $302,000 | 2025 | GENERAL OPERATING |
| PALOMAR HEALTH FOUNDATION | ESCONDIDO, CA | $300,000 | 2025 | GENERAL OPERATING |
| YMCA OF SAN DIEGO COUNTY | SAN DIEGO, CA | $300,000 | 2025 | GENERAL OPERATING |
| NORTH COUNTY HEALTH PROJECT INC | SAN MARCOS, CA | $273,800 | 2025 | GENERAL OPERATING |
| SAN DIEGO ART MATTERS | SAN DIEGO, CA | $260,000 | 2025 | GENERAL OPERATING |
| CYGNET THEATRE COMPANY | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| VISTA COMMUNITY CLINIC | VISTA, CA | $250,000 | 2025 | GENERAL OPERATING |
| NEIGHBORHOOD HEALTHCARE | ESCONDIDO, CA | $250,000 | 2025 | GENERAL OPERATING |
| GROUNDWORK CHOLLAS - SE SAN DIEGO | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| YMCA OF SAN DIEGO COUNTY | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| LA MAESTRA FAMILY CLINIC INC | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| SAN DIEGO VOAD COMMUNITY RECOVERY TEAM | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| FOSTER YOUTH MATCHING GRANTS W LUCKY DUCK | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| CALIFORNIA STATE SAN MARCOS UNIVERSITY FO | SAN MARCOS, CA | $250,000 | 2025 | GENERAL OPERATING |
| MARITIME MUSEUM ASSOCIATION OF SAN DIEGO | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| NORTH COUNTY HEALTH PROJECT INC | SAN MARCOS, CA | $250,000 | 2025 | GENERAL OPERATING |
| CONNECT FOUNDATION | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| FAMILY HEALTH CENTERS OF SAN DIEGO INC | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| MUSEUM OF US | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| FOREVER BALBOA PARK | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| SAN YSIDRO HEALTH | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| RISE URBAN LEADERSHIP INSTITUTE OF SAN DIEGO | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| NATURAL HISTORY MUSEUM (SD OF SOCIETY OF NATURAL HISTORY BALBOA PARK) | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| SAN DIEGO DANCE THEATER | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| PADRES FOUNDATION | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
| THERAPY CENTER INC DBA CHALLENGE CENTER | LA MESA, CA | $250,000 | 2025 | GENERAL OPERATING |
| MUSEUM OF US | SAN DIEGO, CA | $250,000 | 2025 | GENERAL OPERATING |
UC SAN DIEGO FOR THE DEPOT (UC SD FDTN)
$3,000,000GENERAL OPERATING
SAN DIEGO SYMPHONY ORCHESTRA ASSOCIATION
$3,000,000GENERAL OPERATING
SAN DIEGO STATE UNIVERSITY FDTN (KPBS)
$1,600,000GENERAL OPERATING
THE CAMPANILE FOUNDATION SDSU
$1,500,000GENERAL OPERATING
WGBH EDUCATIONAL FOUNDATION
$1,000,000GENERAL OPERATING
SHARP HEALTHCARE FOUNDATION
$1,000,000GENERAL OPERATING
SAN DIEGO ZOO WILDLIFE ALLIANCE
$1,000,000GENERAL OPERATING
SAN DIEGO TIJUANA WORLD DESIGN CAPITAL 2024
$1,000,000GENERAL OPERATING
SCRIPPS RESEARCH INSTITUTE
$750,000GENERAL OPERATING
LA JOLLA INSTITUTE FOR IMMUNOLOGY
$750,000GENERAL OPERATING
NATIONAL CONFLICT RESOLUTION CENTER
$750,000GENERAL OPERATING
SAN DIEGO STATE UNIVERSITY FDTN (KPBS)
$622,200GENERAL OPERATING
WORLD OF WORK FOUNDATION
$500,000GENERAL OPERATING
MUSEUM OF CONTEMPORARY ART SAN DIEGO
$500,000GENERAL OPERATING
NTC FOUNDATION DBA ARTS DISTRICT LIBERTY STATION
$500,000GENERAL OPERATING
THE SALVATION ARMY
$500,000GENERAL OPERATING
UNIVERSITY OF SAN DIEGO
$500,000GENERAL OPERATING
SALK INSTITUTE FOR BIOLOGICAL STUDIES
$500,000GENERAL OPERATING
SDSU (SCHOOL OF PUBLIC HEALTH)
$350,000GENERAL OPERATING
SAN DIEGO MUSEUM OF ART
$325,000GENERAL OPERATING
THE OLD GLOBE
$325,000GENERAL OPERATING
LA JOLLA MUSIC SOCIETY
$325,000GENERAL OPERATING
DOWNTOWN SAN DIEGO PUBLIC SPACES FOUNDATION
$303,000GENERAL OPERATING
SDHC BUILDING OPPORTUNITIES INC
$302,000GENERAL OPERATING
PALOMAR HEALTH FOUNDATION
$300,000GENERAL OPERATING
YMCA OF SAN DIEGO COUNTY
$300,000GENERAL OPERATING
NORTH COUNTY HEALTH PROJECT INC
$273,800GENERAL OPERATING
SAN DIEGO ART MATTERS
$260,000GENERAL OPERATING
CYGNET THEATRE COMPANY
$250,000GENERAL OPERATING
VISTA COMMUNITY CLINIC
$250,000GENERAL OPERATING
NEIGHBORHOOD HEALTHCARE
$250,000GENERAL OPERATING
GROUNDWORK CHOLLAS - SE SAN DIEGO
$250,000GENERAL OPERATING
YMCA OF SAN DIEGO COUNTY
$250,000GENERAL OPERATING
LA MAESTRA FAMILY CLINIC INC
$250,000GENERAL OPERATING
SAN DIEGO VOAD COMMUNITY RECOVERY TEAM
$250,000GENERAL OPERATING
FOSTER YOUTH MATCHING GRANTS W LUCKY DUCK
$250,000GENERAL OPERATING
CALIFORNIA STATE SAN MARCOS UNIVERSITY FO
$250,000GENERAL OPERATING
MARITIME MUSEUM ASSOCIATION OF SAN DIEGO
$250,000GENERAL OPERATING
NORTH COUNTY HEALTH PROJECT INC
$250,000GENERAL OPERATING
CONNECT FOUNDATION
$250,000GENERAL OPERATING
FAMILY HEALTH CENTERS OF SAN DIEGO INC
$250,000GENERAL OPERATING
MUSEUM OF US
$250,000GENERAL OPERATING
FOREVER BALBOA PARK
$250,000GENERAL OPERATING
SAN YSIDRO HEALTH
$250,000GENERAL OPERATING
RISE URBAN LEADERSHIP INSTITUTE OF SAN DIEGO
$250,000GENERAL OPERATING
NATURAL HISTORY MUSEUM (SD OF SOCIETY OF NATURAL HISTORY BALBOA PARK)
$250,000GENERAL OPERATING
SAN DIEGO DANCE THEATER
$250,000GENERAL OPERATING
PADRES FOUNDATION
$250,000GENERAL OPERATING
THERAPY CENTER INC DBA CHALLENGE CENTER
$250,000GENERAL OPERATING
MUSEUM OF US
$250,000GENERAL OPERATING