Dedicated to raising awareness and finding a cure for STXBP1-Related Disorders while improving the lives of patients and families through advocacy, research funding, partnerships with clinicians and scientists, and support for families.
Stxbp1 Foundation concentrates its giving on STXBP1-related disorders, pairing research funding with support for natural history work, clinical studies, and center-of-excellence activity. The largest recent grant on file was $343,881 to Children's Hospital Colorado for a natural history study and center of excellence, a sign that the foundation backs both data collection and research infrastructure around the condition. It also funded $123,751 to Weill Cornell Medicine for a natural history study, showing continued support for patient-focused research that can inform trial readiness and disease understanding. Across its programs, the foundation supports investigator-led basic, preclinical, translational, and clinical research on STXBP1 biology and treatment development. Its public grant programs include seed grants, trainee grants, clinical grants, innovation grants, and an open grant program, with several listed as accepting unsolicited applications. Recent awards also include funding for research at Baylor College of Medicine, Stanford University, and the University of Pennsylvania, reflecting a research network built around academic medical centers and investigators working on STXBP1 disorders.
A major theme is natural history and clinical research. The foundation gave $343,881 to Children's Hospital Colorado for a natural history study and center of excellence, and $123,751 to Weill Cornell Medicine for a natural history study. Those awards fit a broader focus on biomarkers and clinical endpoint development, as well as trial readiness. It also funds translational and therapeutic development work. Baylor College of Medicine received $100,000 for research, while Stanford University received $78,590 for research. In addition, the foundation’s grant programs explicitly support new therapeutics, drug repurposing, and preclinical research. Another visible area is clinical study support. Weill Cornell Medicine received $82,500 for a clinical trial, and the foundation’s clinical grant program is designed to fully support small studies or help cover costs of larger partially funded trials. The portfolio also includes research support at Children's Hospital of Pennsylvania and the University of Pennsylvania.
Typical grant sizes center around six figures: the p25 is $41,516, the median is $66,250, and the p75 is $95,625. The recent-grants list shows both larger anchor awards and smaller research grants, including repeat support for the same institutions across 2024 and 2025. That pattern suggests ongoing relationships rather than isolated one-off awards. The foundation operates as a private grantmaker, not an individual funder, and its programs include unsolicited application pathways for several grant types. Publicly listed grant formats include seed, trainee, clinical, innovation, and open research grants. Some awards can be renewed for a second year at the foundation's discretion.
$829K
$1.5M
$1.4M
$1.3M
Most grants fall between $42K and $96K, with a median of $66K.
25th Percentile
$42K
Median
$66K
75th Percentile
$96K
About 0% of grants go to recipients in PA.
CHARLENE SON RIGBY
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Grant recipients are entirely U.S.-based in the recent-grants sample. Pennsylvania appears most often by grant count, with multiple awards to Philadelphia institutions and Doylestown-based Uplifting Athletes. Other recurring recipient cities include Aurora, New York, Houston, Stanford, and Richmond. The foundation’s HQ is in Holly Springs, North Carolina, but none of the listed recent grants went to North Carolina recipients.
The foundation funds research on STXBP1-related disorders across basic, preclinical, translational, and clinical stages. Public program descriptions also mention natural history studies, biomarkers and clinical endpoint development, neurodegeneration, genotype-phenotype relationships, non-CNS functions of STXBP1, and therapeutic development.
Yes. Several listed programs accept unsolicited applications, including the STXBP1 Foundation Grants Program, the Innovation Grant, the Trainee Grant, the Clinical Grant, the Seed Grant, and the general open grant program.
The grant-size distribution centers on $41,516 at the 25th percentile, a median of $66,250, and $95,625 at the 75th percentile. Recent awards range from smaller research grants to a $343,881 award for a natural history study and center of excellence.
Pennsylvania is the top state by grant count. The recent awards include multiple Philadelphia recipients, plus Doylestown-based Uplifting Athletes, which places a large share of the foundation’s giving in that state.
Yes. The Clinical Grant program funds STXBP1-related clinical studies, either to fully support smaller studies or to help cover costs of larger trials that already have partial funding. Recent giving also includes a $82,500 award to Weill Cornell Medicine for a clinical trial.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Current and upcoming funding from Stxbp1 Foundation that your nonprofit may be able to apply for.
Who can apply: Clinical investigators and research teams affiliated with accredited institutions (US and international).
Deadline: LOIs accepted on a rolling basis.
Who can apply: Investigators affiliated with academic institutions, hospitals, non-profits or accredited research institutions (US and international). Eligible applicants include post-doctoral fellows, clinical fellows, researchers, physicians or other research professionals with faculty appointments or research positions.
Deadline: LOIs accepted on a rolling basis; submit LOI anytime.
Who can apply: Investigators and research teams affiliated with accredited research institutions (US and international).
Deadline: LOIs accepted on a rolling basis.
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Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| CHILDREN'S HOSPITAL COLORADO | AURORA, CO | $343,881 | 2025 | TO FUND NATURAL HISTORY STUDY AND CENTER OF EXCELLENCE |
| WEILL CORNELL MEDICINE | NEW YORK, NY | $123,751 | 2025 | TO FUND NATURAL HISTORY STUDY |
| BAYLOR COLLEGE OF MEDICINE | HOUSTON, TX | $100,000 | 2025 | TO FUND NATURAL HISTORY STUDY |
| STANFORD UNIVERSITY | STANFORD, CA | $78,590 | 2025 | TO FUND RESEARCH |
| CHILDREN'S HOSPITAL OF PENNSYLVANIA | PHILADELPHIA, PA | $60,000 | 2025 | TO FUND RESEARCH |
| UNIVERSITY OF PENNSYLVANIA | PHILADELPHIA, PA | $57,446 | 2025 | TO FUND RESEARCH |
| NYU | NEW YORK, NY | $30,324 | 2025 | TO FUND RESEARCH |
| UNIVERSITY OF RICHMOND | RICHMOND, VA | $25,000 | 2025 | TO FUND RESEARCH |
| UPLIFTING ATHLETES | DOYLESTOWN, PA | $10,000 | 2025 | TO FUND RESEARCH |
| CHILDREN'S HOSPITAL COLORADO | AURORA, CO | $104,399 | 2024 | TO FUND RESEARCH |
| BAYLOR COLLEGE OF MEDICINE | HOUSTON, TX | $100,000 | 2024 | TO FUND RESEARCH |
| WEILL CORNELL MEDICINE | NEW YORK, NY | $82,500 | 2024 | TO FUND CLINICAL TRIAL |
| CHILDREN'S HOSPITAL OF PHILADELPHIA | PHILADELPHIA, PA | $50,000 | 2024 | TO FUND RESEARCH |
| UNIVERSITY OF PENNSYLVANIA - HELLER LAB | PHILADELPHIA, PA | $38,688 | 2024 | TO FUND RESEARCH |
| UPLIIFTING ATHLETES | DOYLESTOWN, PA | $10,000 | 2024 | TO FUND RESEARCH |
| CHILDREN'S HOSPITAL COLORADO | AURORA, CO | $73,000 | 2023 | TO FUND RESEARCH |
| WEILL CORNELL MEDICINE | NEW YORK, NY | $45,000 | 2023 | TO FUND CLINICAL TRIAL |
| UPLIIFTING ATHLETES | DOYLESTOWN, PA | $10,000 | 2023 | TO FUND RESEARCH |
CHILDREN'S HOSPITAL COLORADO
$343,881TO FUND NATURAL HISTORY STUDY AND CENTER OF EXCELLENCE
UPLIFTING ATHLETES
$10,000TO FUND RESEARCH
CHILDREN'S HOSPITAL COLORADO
$104,399TO FUND RESEARCH
UPLIIFTING ATHLETES
$10,000TO FUND RESEARCH
CHILDREN'S HOSPITAL COLORADO
$73,000TO FUND RESEARCH
UPLIIFTING ATHLETES
$10,000TO FUND RESEARCH
