About Rising Tide Foundation for Clinical Cancer Research
Rising Tide Foundation for Clinical Cancer Research funds investigator-led clinical cancer research that is practical, patient-centered, and designed to improve outcomes or reduce burden in real-world care. Their programs emphasize interventional trials, therapy optimization, treatment resistance, early detection/recurrence, and supportive care, with a strong recurring commitment to patient partner involvement and international collaboration. They also support enabling infrastructure and small pre-application grants that help patient organizations and research teams co-develop stronger proposals.
Focus Areas
Clinical Cancer TrialsTherapy Optimization and Treatment ResistanceSupportive OncologyPediatric Blood CancersLung Cancer Recurrence and ResistancePatient Involvement Infrastructure
Giving Approach
Primarily programmatic, competitive grants and joint calls, often via LOI and full-proposal review; awards range from small pre-application supports (~$4,000) to larger multi-year trial grants up to $1M, with some programs covering a set share of project costs rather than full funding. Funding is worldwide and tends to be targeted to specific clinical research calls, sometimes with rolling or periodic cutoff deadlines.
How to approach this funder
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Monitor their program-specific calls closely: many opportunities require an LOI first and then a full proposal, submitted through the SmartSimple portal or the relevant call process. Competitive trials should clearly show clinical relevance, patient partner involvement, scalability, and a strong plan to improve access, reduce toxicity, or address resistance/recurrence; for some awards, applicants should be prepared to cost-share because RTFCCR may fund only a portion of total project costs.
Notable grantees:
• LUNGevity Foundation
• Anticancer Fund
• Cancer patient organizations participating in the Match-making Service RFP
Open Grant Opportunities
Current and upcoming funding from Rising Tide Foundation for Clinical Cancer Research that your nonprofit may be able to apply for.
Open nowCloses in 27 days (Jun 22, 2026)
Open Call (RTFCCR Clinical Cancer Research LOIs)
Therapy OptimizationDisease and Treatment BurdenScience of Early Detection+2 more
Who can apply: Interventional clinical trials (Phase I–III) with patient partner involvement; only institutions where effective grant oversight is feasible; co‑funding expected (RTFCCR typically does not cover total cost).
Deadline: LOIs accepted on a rolling basis with three annual cutoff deadlines (next listed deadlines: 22 June 2026 and 23 November 2026).
Patient partner involvementCapacity building for grant development
Who can apply: Patient organisations or patient partners assisting in development of an RTFCCR grant application; project must be at pre-protocol development stage.
Deadline: Not specified; described as available to support pre-application activities (rolling availability implied).
Clinical cancer researchPredictive informationTreatment strategy optimization+1 more
Who can apply: Academic-led clinical research projects that use predictive information to improve patient survival. Must include institutional co-funding.
Therapy OptimizationDisease and Treatment BurdenScience of Early Detection+2 more
Who can apply: Accepts academic institutions and not-for-profit organizations for innovative, patient-centered interventional clinical trials. Projects should align with RTFCCR focus areas, involve patient partners, and typically require co-funding. The foundation does not fund basic research, phase IV trials, or observational studies.
Deadline: LOIs accepted all year round; internal assessment deadlines occur three times per year.
Patient involvement in clinical trial designClinical cancer research
Who can apply: For projects at the pre-protocol development stage that need patient partner input to shape a grant application/protocol for submission to RTFCCR. Intended for patient organizations or teams working with patient partners on clinical trial development.
Supportive carePalliative oncologyQuality of life+2 more
Who can apply: Applicants must be in their first to third year of a full-time, primary faculty appointment at an academic medical institution worldwide and secure an institutional mentor. Proposals must involve active patient partner participation and measurable outcomes.
Deadline: Program editions run annually; 2026/2027 edition opens from June 2026. Specific 2025/2026 deadlines listed as LOI due 2025-10-30 and full application due 2026-03-06.
Deadlines and eligibility are summarized from public sources and may change — always confirm the details on the funder's official application page before applying.