An independent nonprofit dedicated to funding and facilitating open, collaborative scientific research to achieve clinical breakthroughs for complex chronic diseases such as ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome).
Open Medicine Foundation centers its grantmaking on open, collaborative scientific research for complex chronic diseases, with a strong emphasis on ME/CFS and related biomedical questions. Its recent awards show a pattern of backing both large clinical studies and the research infrastructure that supports them. The largest listed grant went to Mass General Hospital for Dr. Wenzhong Xiao’s research platform work, and another substantial award supported the PLRC monoclonal antibody trial at UCSF Foundation. The foundation also funds specialized disease-mechanism work, such as neutrophil assessment in ME/CFS at Stanford, along with clinical research capacity through stipends, data tools, and technology purchases. That mix suggests a funder focused on accelerating translational research rather than limiting support to one type of project. Across the recent grants list, the foundation backs academic medical centers, university-affiliated research foundations, and individual researchers working within coordinated research programs. The portfolio includes studies of sleep, post-exertional malaise, family omics, biomarker discovery, and computational approaches, all tied to chronic disease research in the ME/CFS field.
In clinical research, Open Medicine Foundation funded a $500,000 monoclonal antibody trial through UCSF Foundation and a $300,000 mestinon trial at Brigham & Women’s Hospital. It also supported a $487,620 sleep study at Beth Israel Deaconess Medical Center, showing an interest in therapeutic testing and symptom physiology. In immune and biomarker work, the foundation gave $633,420 to Stanford-related researchers for neutrophil assessment in ME/CFS and $39,662 to San Jose State University Research Foundation for blood-based biomarkers. It also backed a $54,605 family omics study at Stanford, linking research on patients to work involving family data. The foundation’s portfolio also includes a $62,182 MOSAICS study at Texas Tech University Health Sciences Center and a $10,000 itaconate project at Insilica Labs, reflecting attention to mechanistic and metabolomic questions.
Typical award sizes are moderate to substantial, with a p25 of $28,253, a median of $115,000, and a p75 of $247,725. The recent list shows repeated support to several organizations and researchers across 2023 and 2024, including Bateman Horne Center, Brigham & Women’s Hospital, Boston University, Stanford-related entities, and Mass General Hospital, indicating multi-year relationships rather than one-off gifts. Open Medicine Foundation is an independent nonprofit, not an individual-giving funder, and it does not make program-related investments. Its grantmaking includes both project support and infrastructure-related awards such as research stipends, medical education, technology purchases, and software or app development.
$4.5M
$7.8M
$6.1M
$6.3M
Most grants fall between $28K and $248K, with a median of $115K.
25th Percentile
$28K
Median
$115K
75th Percentile
$248K
About 33% of grants go to recipients in CA.
KIMBERLY HICKS
Top 2 recipient countries by grant volume for Open Medicine Foundation.
| Rank | Country | Grants | Total | Share |
|---|---|---|---|---|
| 1 | United StatesDomestic | 24 | $4.5M | 96.0% |
| 2 | Australia | 1 | $14K |
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Grant recipients are concentrated in the US, with one non-US grant listed in Asia. California is the top state by grant count, and several awards went to recipients in San Francisco, Redwood City, Fremont, San Jose, and San Carlos. Boston-area recipients also appear frequently, including Boston and Cambridge. Other US grants landed in Salt Lake City and Lubbock, showing a national footprint that is still weighted toward a few research hubs. The recipient country distribution also includes one grant outside the US.
The foundation supports ME/CFS and complex chronic disease research across clinical trials, immune and biomarker studies, sleep physiology, family omics, computational genomics, and research infrastructure. Recent grants included a monoclonal antibody trial, a sleep study, neutrophil assessment work, and blood-based biomarker research.
Yes. The recent grants list shows repeated support to several organizations and researchers across 2023 and 2024, including Bateman Horne Center, Brigham & Women’s Hospital, Boston University, Stanford-related entities, and Mass General Hospital.
The listed distribution shows a p25 of $28,253, a median grant of $115,000, and a p75 of $247,725. Awards range from smaller technology and stipend grants to larger multi-hundred-thousand-dollar research platform and clinical trial grants.
California is the top state by grant count, accounting for 33% of grants to recipients in the foundation’s home state. Recent California recipients include organizations in San Francisco, Redwood City, Fremont, San Jose, and San Carlos.
Recipients include academic medical centers, university-affiliated research foundations, and individual researchers working inside coordinated programs. Examples in the recent grants list include Mass General Hospital, UCSF Foundation, Stanford-related entities, and Bateman Horne Center.
2024
Source: IRS Form 990-PF, fiscal year 2024.
Recipient country reflects the grantee's headquarters per IRS 990-PF and Schedule F filings, not the program's implementation country.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| UCSF FOUNDATION | SAN FRANCISCO, CA | $500,000 | 2024 | PLRC - MONOCLONAL ANTIBODY TRIAL |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | BOSTON, MA | $487,620 | 2024 | PLRC - SLEEP STUDY |
| BATEMAN HORNE CENTER | SALT LAKE CITY, UT | $300,000 | 2024 | BHC CRC MEDICAL EDUCATION |
| MASSACHUSETTS GENERAL HOSPITAL | CAMBRIDGE, MA | $197,688 | 2024 | PLRC - NETWORK MEDICINE STUDY |
| WENZHONG XIAO | FREMONT, CA | $150,000 | 2024 | COMPUTATION CRC RESEARCH STIPEND |
| EVIDENT SCIENTIFIC INC | WALTHAM, MA | $121,434 | 2024 | NEUTROPHIL STUDY |
| SIMARON LLC | INCLINE VILLAGE, NV | $120,772 | 2024 | ME/CFS RESEARCH |
| BRIGHAM & WOMEN'S HOSPITAL INC | CAMBRIDGE, MA | $90,805 | 2024 | POST EXTERTIONAL MALAISE MUSCLE BIOPSY STUDY |
| TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER | LUBBOCK, TX | $62,182 | 2024 | PLRC- MOSAICS STUDY |
| BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | REDWOOD CITY, CA | $54,605 | 2024 | FAMILY OMICS STUDY |
| CALIFORNIA ADVANCED LABELING INC | FREMONT, CA | $20,723 | 2024 | PO GMMBH4-LC-CALTW FOR BH4 STUDY |
| DAVID SYSTROM | WINCHESTER, MA | $20,000 | 2024 | HARVARD CRC RESEARCH STIPEND |
| THE TRUSTEES OF BOSTON UNIVERSITY | BOSTON, MA | $15,526 | 2024 | PASS/CAT FINAL DELIVERABLES |
| JOSH WHITKIN CONSULTING | HUNTERS HILL | $13,985 | 2024 | PERSONALIZED TREATMENT TRIAL APP |
| INSILICA LABS INC | EASLEY, SC | $10,000 | 2024 | ITACONATE PROJECT |
| MASS GENERAL HOSPITAL - RESEARCH FOR DR WENZHONG XIAO | BOSTON, MA | $750,000 | 2023 | RESEARCH PLATFORM |
| STANDFORD UNIVERSITY SPONSORED RECEIVABLES - DRS VELASCO CROSBY & DAVIS | REDWOOD CITY, CA | $633,420 | 2023 | NEUTROPHIL ASSESSMENT IN ME/CFS |
| BRIGHAM & WOMEN'S HOSPITAL INC (DAVID SYSTROM) | BOSTON, MA | $300,000 | 2023 | HARVARD CRC - MESTINON TRIAL |
| BATEMAN HORNE CENTER | SALT LAKE CITY, UT | $247,725 | 2023 | BHC CRC MEDICAL EDUCATION |
| TRUSTEES OF BOSTON UNIVERSITY (LEWIS KAZIS) | BOSTON, MA | $185,117 | 2023 | HARVARD CRC - PASS/CAT & REDCAP DEVELOPMENT |
| SIERRA INTERNAL MEDICINE | INCLINE VILLAGE, NV | $115,000 | 2023 | ME/CFS RESEARCH |
| SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION - DR RAMASUBRAMANIAN | SAN JOSE, CA | $39,662 | 2023 | BLOOD-BASED BIOMAKERS FOR ME/CFS |
| FERESHTEH JAHANIANI | SAN CARLOS, CA | $36,000 | 2023 | STANFORD CRC |
| ANTEC SCIENTIFIC | BOSTON, MA | $28,253 | 2023 | STANFORD CFC TECHNOLOGY PURCHASES |
| AGILENT TECHNOLOGIES INC | SANTA CLARA, CA | $8,357 | 2023 | STANFORD CRC TECHNOLOGY PURCHASES |
UCSF FOUNDATION
$500,000PLRC - MONOCLONAL ANTIBODY TRIAL
BETH ISRAEL DEACONESS MEDICAL CENTER INC
$487,620PLRC - SLEEP STUDY
BATEMAN HORNE CENTER
$300,000BHC CRC MEDICAL EDUCATION
MASSACHUSETTS GENERAL HOSPITAL
$197,688PLRC - NETWORK MEDICINE STUDY
WENZHONG XIAO
$150,000COMPUTATION CRC RESEARCH STIPEND
EVIDENT SCIENTIFIC INC
$121,434NEUTROPHIL STUDY
SIMARON LLC
$120,772ME/CFS RESEARCH
BRIGHAM & WOMEN'S HOSPITAL INC
$90,805POST EXTERTIONAL MALAISE MUSCLE BIOPSY STUDY
TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER
$62,182PLRC- MOSAICS STUDY
BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
$54,605FAMILY OMICS STUDY
CALIFORNIA ADVANCED LABELING INC
$20,723PO GMMBH4-LC-CALTW FOR BH4 STUDY
DAVID SYSTROM
$20,000HARVARD CRC RESEARCH STIPEND
THE TRUSTEES OF BOSTON UNIVERSITY
$15,526PASS/CAT FINAL DELIVERABLES
JOSH WHITKIN CONSULTING
$13,985PERSONALIZED TREATMENT TRIAL APP
INSILICA LABS INC
$10,000ITACONATE PROJECT
MASS GENERAL HOSPITAL - RESEARCH FOR DR WENZHONG XIAO
$750,000RESEARCH PLATFORM
STANDFORD UNIVERSITY SPONSORED RECEIVABLES - DRS VELASCO CROSBY & DAVIS
$633,420NEUTROPHIL ASSESSMENT IN ME/CFS
BRIGHAM & WOMEN'S HOSPITAL INC (DAVID SYSTROM)
$300,000HARVARD CRC - MESTINON TRIAL
BATEMAN HORNE CENTER
$247,725BHC CRC MEDICAL EDUCATION
TRUSTEES OF BOSTON UNIVERSITY (LEWIS KAZIS)
$185,117HARVARD CRC - PASS/CAT & REDCAP DEVELOPMENT
SIERRA INTERNAL MEDICINE
$115,000ME/CFS RESEARCH
SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION - DR RAMASUBRAMANIAN
$39,662BLOOD-BASED BIOMAKERS FOR ME/CFS
FERESHTEH JAHANIANI
$36,000STANFORD CRC
ANTEC SCIENTIFIC
$28,253STANFORD CFC TECHNOLOGY PURCHASES
AGILENT TECHNOLOGIES INC
$8,357STANFORD CRC TECHNOLOGY PURCHASES