Accelerating the pursuit of a cure for ALS by funding promising research, amplifying community-driven fundraising, and supporting innovative, high-integrity scientific approaches.
Hop on a Cure Foundation Inc concentrates its giving on ALS, with a grant portfolio built around research that aims to move promising science toward a cure. The foundation’s recent awards show a mix of large institutional grants and repeated support for research groups working on translational and early-stage therapeutic questions. Among the largest recent grants are $475,000 to Massachusetts General Hospital in Boston and $300,000 to Houston Methodist Neurological Institute in Houston, both reflecting the foundation’s emphasis on scientific work with clinical relevance. The foundation also funds specialized ALS research organizations, including the ALS Cure Project and the ALS Therapy Development Institute, suggesting an interest in both discovery and development pathways. Its overall approach aligns with targeted disease research funding, with support extending to biomarker work, immunotherapy, and data-sharing infrastructure. Recent grantmaking also reaches major university-based investigators such as Johns Hopkins University and Duke University School of Medicine, indicating that the foundation works across academic medical centers and dedicated ALS research entities rather than limiting support to a single type of grantee.
ALS research is the core of the foundation’s grantmaking. In 2025, it gave $300,000 to Johns Hopkins University for research, alongside $200,000 to Emory University in Atlanta and $50,000 to Duke University School of Medicine in Durham. The foundation also backs translational and therapeutic development efforts: Houston Methodist Neurological Institute received $300,000 in 2024, and the ALS Therapy Development Institute received $250,000 in 2025. Specialized ALS organizations also appear in the recent grants list, including the ALS Cure Project, which received $250,000 in 2025. Together, these awards point to a portfolio that supports both academic science and organizations focused on advancing ALS treatments.
Typical grants are substantial: the 25th percentile is $145,000, the median is $225,000, and the 75th percentile is $300,000. Recent awards cluster near the top of that range, with multiple grants at $300,000 and several in the $200,000 to $250,000 band. The same recipients can appear across years: Massachusetts General Hospital and Duke University School of Medicine each received grants in both 2024 and 2025, and the ALS Therapy Development Institute and ALS Cure Project also reappeared. The foundation is not a donor-advised fund and does not fund individuals; its active research grant program is competitive and does not accept unsolicited proposals.
$1.4M
$882K
$2.7M
$2.7M
Most grants fall between $145K and $300K, with a median of $225K.
25th Percentile
$145K
Median
$225K
75th Percentile
$300K
About 8% of grants go to recipients in MA.
NICOLE SHEFRIN
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The foundation gives nationally, with all recent grants in the United States. Its most frequent recipient state is North Carolina, and 8% of grants went to recipients in Georgia, the headquarters state. Recent awards reached Boston, Houston, Baltimore, Pleasanton, Watertown, Atlanta, and Durham. The pattern shows a strong concentration in major research hubs, including Massachusetts, North Carolina, Texas, Maryland, California, and Georgia.
It focuses on ALS, especially research that can advance therapeutics, biomarkers, immunotherapy, data sharing, and translational work. Recent awards went to institutions such as Massachusetts General Hospital, Johns Hopkins University, and the ALS Therapy Development Institute, showing a strong research orientation.
Typical grants are in the six-figure range. The 25th percentile is $145,000, the median is $225,000, and the 75th percentile is $300,000. Recent awards also include a $475,000 grant, which sits above the usual range.
No. Recent recipients include academic medical centers, universities, and ALS-focused research organizations. The grant list includes Massachusetts General Hospital, Houston Methodist Neurological Institute, Johns Hopkins University, Duke University School of Medicine, the ALS Cure Project, and the ALS Therapy Development Institute.
The foundation gives nationally, and all recent grants in the data went to U.S. recipients. North Carolina is the top state by grant count, while Georgia, the headquarters state, received 8% of grants. Recent recipients were located in Boston, Houston, Baltimore, Pleasanton, Watertown, Atlanta, and Durham.
Several recipients appear in more than one year, which suggests repeat support. Massachusetts General Hospital received awards in 2024 and 2025, Duke University School of Medicine also received grants in both years, and the ALS Therapy Development Institute and ALS Cure Project each appear more than once in the recent grants list.
2025
Source: IRS Form 990-PF, fiscal year 2025.
Current and upcoming funding from Hop on A Cure Foundation that your nonprofit may be able to apply for.
Who can apply: Applicants should be entities engaged in ALS research or related scientific work. The site states funding supports researchers, collaborative teams, academic institutions, hospitals, nonprofits, and privately held biotech companies dedicated to accelerating scientific breakthroughs in ALS.
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Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| MASSACHUSETTS GENERAL HOSPITAL | BOSTON, MA | $300,000 | 2025 | — |
| JOHN HOPKINS UNIVERSITY | BALTIMORE, MD | $300,000 | 2025 | — |
| ALS THERAPY DEVELOPMENT INSTITUTE | WATERTOWN, MA | $250,000 | 2025 | — |
| ALS CURE PROJECT | PLEASANTON, CA | $250,000 | 2025 |
| — |
| EMORY UNIVERSITY | ATLANTA, GA | $200,000 | 2025 | — |
| DUKE UNIVERSITY SCHOOL MEDICINE | DURHAM, NC | $50,000 | 2025 | — |
| MASSACHUSETTS GENERAL HOSPITAL | BOSTON, MA | $475,000 | 2024 | — |
| HOUSTON METHODIST NEUROLOGICAL INSTITUTE | HOUSTON, TX | $300,000 | 2024 | — |
| DUKE UNIVERSITY SCHOOL MEDICINE | DURHAM, NC | $170,000 | 2024 | — |
| ALS THERAPY DEVELOPMENT INSTITUTE | WATERTOWN, MA | $160,000 | 2024 | — |
| ROBERT PACKARD CENTER FOR ALS RESEARCH | BALTIMORE, MD | $100,000 | 2024 | — |
| ALS CURE PROJECT | PLEASANTON, CA | $75,000 | 2024 | — |
MASSACHUSETTS GENERAL HOSPITAL
$300,000JOHN HOPKINS UNIVERSITY
$300,000ALS CURE PROJECT
$250,000EMORY UNIVERSITY
$200,000MASSACHUSETTS GENERAL HOSPITAL
$475,000DUKE UNIVERSITY SCHOOL MEDICINE
$170,000ALS CURE PROJECT
$75,000