To unite the global Leigh syndrome community to accelerate patient-centered research, treatments, and cures.
Cure Mito Foundation concentrates on Leigh syndrome research, with funding and collaborations that move from gene therapy and drug repurposing to mitochondria transfer and transplantation studies. Its recent grant activity includes a $201,437 research award to Biologics and a $105,700 research initiative to University of Texas Southwestern, showing support for both project-based science and institution-linked work. The foundation also backs translational efforts tied to clinical trial readiness, alongside microbiome research and patient-registry development as part of its broader mitochondrial disease agenda. The foundation’s work is organized around targeted research programs rather than broad unrestricted support. In the recent grants list, Perlara received $13,500 for a research initiative, while UCLA received $11,409 for research, both within the same Leigh syndrome and mitochondrial-disease framework. Cure Mito Foundation’s stated purpose is to unite the global Leigh syndrome community to accelerate patient-centered research, treatments, and cures, and its grantmaking reflects that focus through partnerships with academic institutions, research teams, and specialized labs.
In gene therapy, Cure Mito Foundation supported University of Texas Southwestern with a $105,700 research initiative, aligning with its emphasis on Leigh syndrome-related genes such as SURF1, ECHS1, and MT-ATP6. In translational work, Biologics received $201,437 for research, reflecting the foundation’s interest in moving projects toward practical treatment development. The foundation also funds research on alternative therapeutic approaches. Perlara received $13,500 for a research initiative, fitting the drug repurposing and preclinical screening theme in the funder’s program areas. UCLA received $11,409 for research, showing continued support for academic projects within the Leigh syndrome and mitochondrial disease portfolio. Across these awards, the foundation backs investigator-led work, academic partnerships, and projects that can advance clinical trial preparedness.
Cure Mito Foundation’s active research grantmaking includes awards ranging from $34,000 to $400,000, with a median recent grant size near the lower end of that band based on the listed awards. The top recent grant was $201,437, and the foundation also made a $105,700 award, indicating a mix of mid-sized and smaller project grants. It is a Public Charity and does not fund individuals. The grant programs include both unsolicited opportunities and targeted collaborations, with some programs explicitly accepting proposals and others operating by invitation or partnership. Recent awards point to repeated project-based support across the same research theme rather than one-off community grants.
$373K
$1.1M
$479K
$502K
About 20% of grants go to recipients in CA.
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Recent grants in the file all went to U.S. recipients, including Irvine and Los Angeles in California, Dallas in Texas, South San Francisco in California, and Tucson in Arizona. California appears multiple times among the named recipient cities, while Texas appears in the recent list through Dallas. The recipient country distribution is entirely U.S.-based, with 5 grants listed at 100.0% in the United States. Although the foundation is headquartered in McKinney, Texas, the giving shown here reaches beyond Texas and is not centered there.
Its active programs focus on Leigh syndrome and related mitochondrial diseases, including gene therapy, drug repurposing, mitochondria transfer and transplantation, microbiome studies, preclinical and translational research, patient registry development, and clinical trial preparedness.
Yes, for some programs. The Leigh Syndrome Research Retreat and Workshop and the Leigh Syndrome Research Grants program both list unsolicited proposals as accepted, while other targeted collaboration programs do not.
The foundation’s general research funding program lists grant sizes from $34,000 to $400,000. In the recent grant list, awards range from $10,000 to $201,437, showing a mix of smaller and larger project-based grants.
The foundation funds researchers, academic institutions, and research teams. Recent recipients include Biologics, University of Texas Southwestern, Perlara, UCLA, and Critical Path Institute.
No. Although the foundation is headquartered in McKinney, Texas, recent grants went to recipients in California, Texas, and Arizona, and the program descriptions describe global, U.S., and Europe-oriented giving.
2026
Source: IRS Form 990-PF, fiscal year 2026.
Most recent grants reported to the IRS.
| Recipient | Location | Amount | Year | Purpose |
|---|---|---|---|---|
| UT SOUTHWESTERN | DALLAS, TX | $218,556 | 2026 | RESEARCH INTIATIVE |
| WASHINTON UNIVERSITY | SEATTLE, WA | $70,000 | 2026 | RESEARCH |
| ICAHN MEDICAL SCHOOL | NEW YORK, NY | $34,000 | 2026 | RESEARCH |
| UNRAVEL NEUROMARKETING RESEARCH | RENO, NV | $33,250 | 2026 | RESEARCH INITIATIVE |
| UNIVERSITY OF CALIFORNIA | LOS ANGELES, CA | $17,651 | 2026 | RESEARCH INITIATIVE |
| BIOLOGICS | IRVINE, CA | $201,437 | 2025 | RESEARCH |
| UNIVERSITY OF TEXAS SOUTHWESTERN | DALLAS, TX | $105,700 | 2025 | RESEARCH INITIATIVE |
| PERLARA | SOUTH SAN FRANCISCO, CA | $13,500 | 2025 | RESEARCH INTIATIVE |
| UCLA | LOS ANGELES, CA | $11,409 | 2025 | RESEARCH |
| CRITICAL PATH INSTITUTE | TUCSON, AZ | $10,000 | 2025 | RESEARCH INITIATIVE |
UT SOUTHWESTERN
$218,556RESEARCH INTIATIVE
WASHINTON UNIVERSITY
$70,000RESEARCH
UNRAVEL NEUROMARKETING RESEARCH
$33,250RESEARCH INITIATIVE
UNIVERSITY OF CALIFORNIA
$17,651RESEARCH INITIATIVE
BIOLOGICS
$201,437RESEARCH
UNIVERSITY OF TEXAS SOUTHWESTERN
$105,700RESEARCH INITIATIVE
PERLARA
$13,500RESEARCH INTIATIVE
UCLA
$11,409RESEARCH